Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume 7, Issue 7, Pages 549-560
Publisher
Informa Healthcare
Online
2012-05-20
DOI
10.1517/17460441.2012.688743
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Small Molecule Inhibitors of Human DNA Polymerase λ
- (2011) Tobias Strittmatter et al. ACS Chemical Biology
- Design, Synthesis and Evaluation of Novel Rhodanine-containing Sorafenib Analogs as Potential Antitumor Agents
- (2011) Wei Li et al. ARCHIV DER PHARMAZIE
- Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors
- (2011) Xiao-Yang He et al. BIOORGANIC & MEDICINAL CHEMISTRY
- New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds
- (2011) Sabrina Heng et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure–activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B
- (2011) Richard T. Carroll et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors
- (2011) Koichiro Harada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure-Based Virtual Screening Approach to the Discovery of Novel Inhibitors of Eyes Absent 2 Phosphatase with Various Metal Chelating Moieties
- (2011) Hwangseo Park et al. Chemical Biology & Drug Design
- Toward the Discovery of Novel Anti-HIV Drugs. Second-Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
- (2011) Giovanni Maga et al. ChemMedChem
- Challenges of Antibacterial Discovery
- (2011) L. L. Silver CLINICAL MICROBIOLOGY REVIEWS
- New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: Design, synthesis, crystal structures, and biological evaluation
- (2011) Nace Zidar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting d-Glu- and diphosphate-binding sites
- (2011) Tihomir Tomašić et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization
- (2011) Valeria La Pietra et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design of a New Series ofd-Glutamic Acid Based Inhibitors of Bacterial UDP-N-acetylmuramoyl-l-alanine:d-glutamate Ligase (MurD)
- (2011) Tihomir Tomašić et al. JOURNAL OF MEDICINAL CHEMISTRY
- Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry
- (2011) Thomas Mendgen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sulfenic acids as reactive intermediates in xenobiotic metabolism
- (2010) Daniel Mansuy et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase
- (2010) Tanaji T. Talele et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Novel rhodanine derivatives induce growth inhibition followed by apoptosis
- (2010) Balaji T. Moorthy et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors
- (2010) Rosanna Maccari et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
- (2010) Leandro C. Cerchietti et al. CANCER CELL
- False Positives in the Early Stages of Drug Discovery
- (2010) R. Sink et al. CURRENT MEDICINAL CHEMISTRY
- The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains
- (2010) Diane Hardej et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of new chalcone derivatives containing a rhodanine-3-acetic acid moiety with potential anti-bacterial activity
- (2010) Zhen-Hua Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
- (2010) Dmytro Havrylyuk et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Observations on screening-based research and some concerning trends in the literature
- (2010) Jonathan B Baell Future Medicinal Chemistry
- On the mechanism of CFTR inhibition by a thiazolidinone derivative
- (2010) Zoia Kopeikin et al. JOURNAL OF GENERAL PHYSIOLOGY
- Discovery of Novel 5-Benzylidenerhodanine and 5-Benzylidenethiazolidine-2,4-dione Inhibitors of MurD Ligase
- (2010) Nace Zidar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Insights into the Design of Small Molecule Inhibitors That Selectively Antagonize Mcl-1
- (2010) Paul H. Bernardo et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of novel small molecule activators of nuclear factor-κb with neuroprotective action via high-throughput screening
- (2010) Marina S. Manuvakhova et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs
- (2009) Tushar K. Beuria et al. BIOCHEMICAL JOURNAL
- Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases
- (2009) Daniel Aiello et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors
- (2009) Nuttee Suree et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur Ligases
- (2009) Tihomir Tomašić et al. ChemMedChem
- Rhodanine as a Privileged Scaffold in Drug Discovery
- (2009) T. Tomasic et al. CURRENT MEDICINAL CHEMISTRY
- Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones
- (2009) Tihomir Tomašić et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Structure−Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors⊥
- (2009) Alan R. Katritzky et al. JOURNAL OF MEDICINAL CHEMISTRY
- Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
- (2009) Sudipta Saha et al. TOXICOLOGY LETTERS
- Interaction geometries and energies of hydrogen bonds to C=O and C=S acceptors: a comparative study
- (2008) Peter A. Wood et al. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
- Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase
- (2008) Tihomir Tomašić et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase
- (2008) Kerim Babaoglu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp
- (2008) R. E. Georgescu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More