Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

Title
Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements
Authors
Keywords
Biopharmaceutics Classification System (BCS), biowaiver, Caco-2 cells, Food and Drug Administration (FDA), human intestinal permeability, <em class=EmphasisTypeItalic >in silico</em> modeling, <em class=EmphasisTypeItalic >in vitro</em> screening
Journal
AAPS Journal
Volume 15, Issue 2, Pages 483-497
Publisher
American Association of Pharmaceutical Scientists (AAPS)
Online
2013-01-24
DOI
10.1208/s12248-013-9456-8

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