Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Perception of the plant immune signal salicylic acid

(2014) Shunping Yan et al.   CURRENT OPINION IN PLANT BIOLOGY

Trojan Genes and Transparent Genomes: Sexual Selection, Regulatory Evolution and the Real Hopeful Monsters

(2014) C. David Rollo   Evolutionary Biology

Early Life Hormetic Treatments Decrease Irradiation-Induced Oxidative Damage, Increase Longevity, and Enhance Sexual Performance during Old Age in the Caribbean Fruit Fly

(2014) Giancarlo López-Martínez et al.   PLoS One

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Exceptional longevity in female Rottweiler dogs is not encumbered by investment in reproduction

(2013) S. S. Kengeri et al.   AGE

AMPK activation—protean potential for boosting healthspan

(2013) Mark F. McCarty   AGE

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

(2013) Stephen R. Spindler et al.   AGE

Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast

(2013) Kyung-Mi Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin: Do we finally have an anti-aging drug?

(2013) Vladimir N. Anisimov   CELL CYCLE

Hormesis and longevity with tannins: Free of charge or cost-intensive?

(2013) Nadine Saul et al.   CHEMOSPHERE

Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span

(2013) Janneke Wit et al.   EXPERIMENTAL GERONTOLOGY

Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

(2013) Qin-Li Wan et al.   EXPERIMENTAL GERONTOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

(2013) Andrzej Bartke et al.   PHYSIOLOGICAL REVIEWS

Influence on Longevity of Blueberry, Cinnamon, Green and Black Tea, Pomegranate, Sesame, Curcumin, Morin, Pycnogenol, Quercetin, and Taxifolin Fed Iso-Calorically to Long-Lived, F1 Hybrid Mice

(2013) Stephen R. Spindler et al.   REJUVENATION RESEARCH

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans

(2012) Srinivas Ayyadevara et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

Longer Life Span Evolves under High Rates of Condition-Dependent Mortality

(2012) Hwei-yen Chen et al.   CURRENT BIOLOGY

Life History Features and Aging Rates: Insights from Intra-specific Patterns in the Cricket Acheta domesticus

(2012) Janice Lyn et al.   Evolutionary Biology

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging

(2012) Jiangang Long et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Compensatory mechanisms for ameliorating the fundamental trade-off between predator avoidance and foraging

(2012) Jennifer S. Thaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

(2011) Vadim Aksenov et al.   AGE

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Cricket body size is altered by systemic RNAi against insulin signaling components and epidermal growth factor receptor

(2011) Noha Dabour et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Salicylic acid beyond defence: its role in plant growth and development

(2011) M. Rivas-San Vicente et al.   JOURNAL OF EXPERIMENTAL BOTANY

Influence of two methods of dietary restriction on life history features and aging of the cricket Acheta domesticus

(2010) Janice Christina Lyn et al.   AGE

Protective effect of metformin in CD1 mice placed on a high carbohydrate–high fat diet

(2010) Min Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

Ecological processes in a hormetic framework

(2010) David Costantini et al.   ECOLOGY LETTERS

Survival costs of reproduction in Drosophila

(2010) Thomas Flatt   EXPERIMENTAL GERONTOLOGY

Drosophila melanogasteras a model system for the evaluation of anti-aging compounds

(2010) Mahtab Jafari   FLY

Trade-off acquisition and allocation in Gryllus firmus: a test of the Y model

(2010) E. G. KING et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Plant Immunity: It's the Hormones Talking, But What Do They Say?

(2010) A. Verhage et al.   PLANT PHYSIOLOGY

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

A systematic look at an old problem

(2008) Thomas B. L. Kirkwood   NATURE

Kinetics of Salicylate-Mediated Suppression of Jasmonate Signaling Reveal a Role for Redox Modulation

(2008) A. Koornneef et al.   PLANT PHYSIOLOGY