Review
Nutrition & Dietetics
Xinlu Guo, Junjie Luo, Jingyi Qi, Xiya Zhao, Peng An, Yongting Luo, Guisheng Wang
Summary: The increasing elderly proportion of the population poses burdens on society, the economy, and the medical field. Polysaccharides have gained attention for their potential use in anti-aging therapies due to their natural and efficient biological properties, including antioxidant, anti-inflammatory, and immune regulatory activities.
Article
Biology
Stefanny Villalobos-Cantor, Ruth M. Barrett, Alec F. Condon, Alicia Arreola-Bustos, Kelsie M. Rodriguez, Michael S. Cohen, Ian Martin
Summary: Controlled protein synthesis is crucial for regulating gene expression in a cell type-specific manner. We developed a new method to specifically label and visualize newly-synthesized proteins in targeted cell populations in the fly brain, allowing for quantitative analysis of protein synthesis states in vivo.
Article
Cell Biology
Tai-Ting Lee, Po-Lin Chen, Matthew P. Su, Jian-Chiuan Li, Yi-Wen Chang, Rei-Wen Liu, Hsueh-Fen Juan, Jinn-Moon Yang, Shih-Peng Chan, Yu-Chen Tsai, Sophia von Stockum, Elena Ziviani, Azusa Kamikouchi, Horng-Dar Wang, Chun-Hong Chen
Summary: By using the Drosophila melanogaster model, researchers discovered that the mitochondrial outer membrane protein Fis1 plays a crucial role in muscle dysfunction and several age-related conditions, with mutations leading to damaged mitochondria, increased oxidative stress, and decreased muscle function. Mutations in Fis1 also affect mitochondrial proteostasis in fly muscle, reducing flight capabilities and lifespan, indicating the significance of Fis1 in fly mitochondrial dynamics.
Article
Chemistry, Medicinal
Yanyu Feng, Hanjin Lu, Jiamiao Hu, Baodong Zheng, Yi Zhang
Summary: This study demonstrates that R-phycocyanin (R-PC) extracted from Porphyra haitanensis possesses antioxidant activity and can inhibit the generation of radicals. It also prevents cell aging by regulating cell cycle-related proteins. The findings suggest that R-PC may have potential as an anti-aging agent.
Article
Chemistry, Multidisciplinary
Manuel Mangoni, Francesco Petrizzelli, Niccolo Liorni, Salvatore Daniele Bianco, Tommaso Biagini, Alessandro Napoli, Marta Adinolfi, Pietro Hiram Guzzi, Antonio Novelli, Viviana Caputo, Tommaso Mazza
Summary: The process of aging involves a decline in physiological functions and mitochondrial dysfunction is thought to play a significant role. In this study, Drosophila melanogaster was used as a model organism to study aging, and graph theory was employed to analyze gene expression patterns. Mitochondrial genes, including UQCR-C1, ND-B17.2, ND-20, and Pdhb, were found to be important in aging and age-related diseases. These findings demonstrate the role of mitochondrial genes in the aging process and the usefulness of Drosophila melanogaster and graph theory in aging research.
APPLIED SCIENCES-BASEL
(2023)
Article
Nutrition & Dietetics
Hye-Yeon Lee, Bora Lee, Eun-Ji Lee, Kyung-Jin Min
Summary: Dietary restriction (DR) is a widely accepted strategy to increase lifespan and stress resistance in eukaryotic organisms. This study investigated the effects of parental DR on the fitness of their offspring and found that the offspring displayed increased body weight, stress resistance, and lifespan. However, the development and fecundity of the offspring were not affected. Interestingly, parental DR led to a reduction in the feeding rate of their offspring. These findings suggest that the effects of DR can extend to the offspring and should be considered in studies on aging.
Article
Biochemistry & Molecular Biology
Ekaterina Proshkina, Elena Yushkova, Liubov Koval, Nadezhda Zemskaya, Evgeniya Shchegoleva, Ilya Solovev, Daria Yakovleva, Natalya Pakshina, Natalia Ulyasheva, Mikhail Shaposhnikov, Alexey Moskalev
Summary: Small RNAs play a crucial role in coordinating various cellular processes, affecting gene expression, genomic stability, and suppressing mutagenic transposon activity, thus influencing aging, longevity, and sensitivity to stress factors. Proteins of the Argonaute family are essential for the biogenesis and activity of small RNAs, but their role in regulating lifespan and radioresistance is still not well understood. Studies on knockdown of Argonaute genes in different tissues of Drosophila melanogaster show tissue-specific effects on lifespan, survival after irradiation, and retrotransposon levels, providing insights into the associated molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Taylor Barwell, Sehaj Raina, Laurent Seroude
Summary: This article introduces a versatile locomotion measuring device and custom MatLab scripts for data extraction, analysis, and compilation. The study demonstrates that normal aging is associated with a progressive decline in locomotion over time.
Article
Biochemistry & Molecular Biology
Ganiyu Oboh, Damilola M. Olatunde, Ayokunle O. Ademosun, Opeyemi B. Ogunsuyi
Summary: The study demonstrated that citrus peels such as orange, tangerine, and grapefruit have potential life span promoting properties in Drosophila melanogaster. These citrus peels improved longevity, locomotor performance, memory, antioxidant status, and enzyme activities in treated flies. This suggests that citrus peels could be used as dietary supplements and functional food additives.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Cell Biology
Eli Hagedorn, Dean Bunnell, Beate Henschel, Daniel L. Smith, Stephanie Dickinson, Andrew W. Brown, Maria De Luca, Ashley N. Turner, Stanislava Chtarbanova
Summary: Aging increases vulnerability to viral infections and impacts organismal survival. Virus infection modulates host metabolism, but the effect of aging on metabolic reprogramming remains poorly understood. Using a host-virus model, we found that metabolic profile influences viral infection outcomes.
Article
Microbiology
Fang Zhang, Liying Wang, Jiayu Jin, Yulu Pang, Hao Shi, Ziyi Fang, Han Wang, Yujie Du, Yufan Hu, Yingchun Zhang, Xiaoyue Ding, Zuobin Zhu
Summary: This study investigated the impact of Escherichia coli mutant strains on fruit fly lifespan and found that feeding E. coli purE strain resulted in the longest lifespan in fruit flies, which was also validated in Caenorhabditis elegans. RNA sequencing and analysis revealed that E. coli mutant strains affect lifespan by regulating protein synthesis rate and ATP levels. This research provides new insights into the genetic influences of gut microbiota on host lifespan and offers a foundation for developing anti-aging probiotics and drugs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Andrew P. K. Wodrich, Andrew W. Scott, Edward Giniger
Summary: By asking questions about the nature of aging and examining data from Drosophila melanogaster, this study explores the complex interactions among age-related phenotypes at different biological levels. The differing perspectives on aging shed light on its properties and mechanisms, offering potential paths for understanding the nature of aging.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Cell Biology
Karl M. Glastad, Julian Roessler, Janko Gospocic, Roberto Bonasio, Shelley L. Berger
Summary: In this study, the researchers investigate the role of heat shock responses mediated by hsalHSF2 in extending the longevity and survival of reproductive gamergate ants. They show that the increased heat stress resilience and life span benefits observed in gamergates can be transferred to fruit flies through the expression of hsalHSF2. The study sheds light on the mechanisms underlying the extended life span of gamergates, highlighting the significance of hsalHSF2 in ant longevity. It also underscores the importance of proteostasis in health and aging, as well as the potential for facultative life span extension in ants.
GENES & DEVELOPMENT
(2023)
Article
Food Science & Technology
Yi Zhang, Hongfei Cai, Zhu Tao, Cheng Yuan, Zhaojian Jiang, Juyan Liu, Hiroshi Kurihara, Wendong Xu
Summary: Studies have shown that Ganoderma lucidum spore oil (GLSO) can effectively extend lifespan and enhance antioxidant enzyme activity in Drosophila, suggesting its potential as a functional food for anti-aging purposes.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Biochemistry & Molecular Biology
Yanyu Feng, Hanjin Lu, Jiamiao Hu, Baodong Zheng, Yi Zhang
Summary: The research showed that R-phycocyanin (R-PC) has anti-aging activity. It was also found that the effectiveness of anti-aging drugs may vary between genders. Therefore, the study aimed to investigate the differential effects and underlying molecular mechanisms of R-PC on aging in male and female drosophila melanogaster. The results showed that R-PC exerted anti-aging effects through different mechanisms in male and female drosophila melanogaster.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)