Potentiality and Synthesis of O- and N-Heterocycles: Pd-Catalyzed Cyclocarbonylative Sonogashira Coupling as a Valuable Route to Phthalans, Isochromans, and Isoindolines

Recent Advances in Functionalization of α-C(sp3 )-H Centres in Inactivated Ethers through Cross Dehydrogenative Coupling

(2017) Aanchal Batra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of N-Heteroaromatic Compounds through Cyclocarbonylative Sonogashira Reactions

(2017) Laura Antonella Aronica et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalyst-free synthesis of fused 1,2,3-triazole and isoindoline derivatives via an intramolecular azide–alkene cascade reaction

(2017) Yu-Yang Xie et al.   GREEN CHEMISTRY

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

(2017) Shih-Chia Tso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of Functionalized 1,3-Disubstituted Isoindolines via Rh(III)-Catalyzed Tandem Oxidative Olefination-Cyclization of 4-Aryl-cyclic Sulfamidate-5-Carboxylates

(2017) Raghavendra Achary et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Synthesis of N-Heterocycles via Direct C(sp3)–H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand

(2017) Bidraha Bagh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel synthesis of isoindoline/isoindoline-1,3-dione derivatives under solventless conditions and evaluation with the human D2 receptor

(2017) Erik Andrade-Jorge et al.   MEDICINAL CHEMISTRY RESEARCH

Isoindoline nitroxide-labeled porphyrins as potential fluorescence-suppressed spin probes

(2017) F. Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ferric nitrate-catalyzed aerobic oxidation of benzylic sp 3 C H bonds of ethers and alkylarenes

(2017) Chao Hong et al.   TETRAHEDRON

The dehydro Diels-Alder (DDA) reaction based approach to isofuranonaphthalenone, nodulones A-C and xestolactone A

(2017) Bhavani Shankar Chinta et al.   TETRAHEDRON

Aryne formation via the hexadehydro Diels-Alder reaction and their Ritter-type transformations catalyzed by a cationic silver complex

(2017) Sourav Ghorai et al.   TETRAHEDRON

Synthesis of phthalan and phenethylamine derivatives via addition of alcohols to rhodium(II)-azavinyl carbenoids

(2017) John M. Bennett et al.   TETRAHEDRON LETTERS

Recent advancements in dehydrogenative cross coupling reactions for CC bond formation

(2017) Begur Vasanthkumar Varun et al.   TETRAHEDRON LETTERS

Novel isochroman-triazoles and thiadiazole hybrids: Design, synthesis and antimicrobial activity

(2017) Aamer Saeed et al.   Journal of Saudi Chemical Society

[2+2+2]-Cyclotrimerization of 1-Cyclopropyl-1,6-diynes with Alkynes: Formation of Cyclopropylarenes.

(2016) Eliška Matoušová et al.   ADVANCED SYNTHESIS & CATALYSIS

Diastereoselective Synthesis of Substituted Tetrahydroisoquinolines and Isoindolinesviaa Silver(I) Triflate-Promoted Tandem Reaction

(2016) Siyang Xing et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Allylic C−H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis

(2016) Stephen E. Ammann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isoindoline Derivatives of α-Amino Acids as Cyclooxygenase 1 and 2 Inhibitors

(2016) Teresa Mancilla-Percino et al.   ARCHIV DER PHARMAZIE

One New Compound from the Extract of the Fungus Monascus purpureus BCRC 31499

(2016) Ming-Jen Cheng et al.   CHEMISTRY OF NATURAL COMPOUNDS

A Selective RhI -Catalyzed Substrate-Controlled C−C Bond Activation of Benzyl Sulfonamide/Alcohol-Tethered Alkylidenecyclopropanes

(2016) Kai Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of DNA-Intercalating 6H-Benzo[c]chromen-6-one Derivatives through a Strategic Combination of Garratt-Braverman and Minisci Acyloxylation Reactions

(2016) Prabuddha Bhattacharya et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

MDIMP, a novel cardiac Ca2+ channel blocker with atrial selectivity

(2016) Mireille Aline Santamaria-Herrera et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fullerenol spin probe containing isoindoline nitroxide and porphyrin groups

(2016) Fan Liu et al.   FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES

Synthesis of N,N-Disubstituted 1-Aryl-1,3-dihydro-2H-isoindole-2-carbothioamides

(2016) Kazuhiro Kobayashi et al.   HETEROCYCLES

A rapid method for the analysis of methyl dihydrojasmonate and galaxolide in indoor and outdoor air particulate matter

(2016) Marta Fontal et al.   JOURNAL OF CHROMATOGRAPHY A

Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease

(2016) Augustin Amour et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemodivergent fungal oxidation of isochroman

(2016) Gabriela I. Furque et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Isochromans and Related Constituents from the Endophytic Fungus Annulohypoxylon truncatum of Zizania caduciflora and Their Anti-Inflammatory Effects

(2016) Wei Li et al.   JOURNAL OF NATURAL PRODUCTS

Reactions of HDDA-Derived Benzynes with Sulfides: Mechanism, Modes, and Three-Component Reactions

(2016) Junhua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On- and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis

(2016) David D. Ford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two new phenylpropanoids from Swertia atroviolacea and their anti-5α-reductase activity

(2016) Hai-Yan Wu et al.   NATURAL PRODUCT RESEARCH

The pentadehydro-Diels–Alder reaction

(2016) Teng Wang et al.   NATURE

Oxidative cleavage of 1-aryl-isochroman derivatives using the Trametes villosa laccase/1-hydroxybenzotriazole system

(2016) Roberta Bernini et al.   NEW JOURNAL OF CHEMISTRY

Gold-catalyzed π-directed regioselective cyclization of bis(o-alkynyl benzyl alcohols): rapid access to dihydroisobenzofuran derivatives

(2016) Ziping Cao et al.   NEW JOURNAL OF CHEMISTRY

Hydrohalogenative aromatization of multiynes promoted by ruthenium alkylidene complexes

(2016) Rajdip Karmakar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Photoredox-Catalyzed Three-Component Tandem Process: An Assembly of Complex Trifluoromethylated Phthalans and Isoindolines

(2016) Lucie Jarrige et al.   ORGANIC LETTERS

The Phenol–Ene Reaction: Biaryl Synthesis via Trapping Reactions between HDDA-Generated Benzynes and Phenolics

(2016) Juntian Zhang et al.   ORGANIC LETTERS

Heteroscorpionate Rare-Earth Catalysts for the Hydroalkoxylation/Cyclization of Alkynyl Alcohols

(2016) Javier Martínez et al.   ORGANOMETALLICS

Synthesis of Isochroman Derivatives via Oxa-Pictet–Spengler Reaction of Vinylogous Esters

(2016) Anil Saikia et al.   SYNTHESIS-STUTTGART

Room-temperature direct benzylic oxidation catalyzed by cobalt(II) perchlorate

(2016) Yiwen Yang et al.   TETRAHEDRON LETTERS

Anion-Abstraction Catalysis: The Cooperative Mechanism of α-Chloroether Activation by Dual Hydrogen-Bond Donors

(2016) David D. Ford et al.   ACS Catalysis

Iron(III)-Catalyzed 1,3-Functional Group Transposition Reactions: Synthetic Protocol to Access 3-Substituted Indoles

(2016) De-Yao Li et al.   Asian Journal of Organic Chemistry

The Total Synthesis and Structural Assignment of Hexaketide Xylarinol B and its C1′-Epimer

(2016) Venkannababu Mullapudi et al.   Asian Journal of Organic Chemistry

RhII-Catalyzed Cyclization of Ester/Thioester-ContainingN-Sulfonyl-1,2,3-triazoles: Facile Synthesis of Alkylidenephthalans and Alkylidenethiophthalans

(2016) Run Sun et al.   Asian Journal of Organic Chemistry

Reactivity and mechanistic insight into the cross coupling reaction between isochromans and β-keto esters through C–H bond activation under visible light irradiation

(2016) Ming Xiang et al.   Organic Chemistry Frontiers

Practical Solvent-Free Ruthenium Trichloride-Mediated Benzannulation Approach to Fused Functionalized Arenes

(2015) Jeremy Jacquet et al.   ADVANCED SYNTHESIS & CATALYSIS

DDQ-mediated Direct C(sp3)H Cyanation of Benzyl Ethers and 1,3-Diarylpropenes under Solvent- and Metal-free Conditions

(2015) Shanshan Kong et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective Oxidation of Amines to Aldehydes or Imines using Laccase-Mediated Bio-Oxidation

(2015) Paola Galletti et al.   ADVANCED SYNTHESIS & CATALYSIS

Di-tert-butyl Peroxide (DTBP)-Mediated Oxidative Cross- Coupling of Isochroman and Indole Derivatives

(2015) Likun Jin et al.   ADVANCED SYNTHESIS & CATALYSIS

Lewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters

(2015) Yuehui Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Copper(I)-Catalyzed Alkynylation of Oxocarbenium Ions to Set Diaryl Tetrasubstituted Stereocenters

(2015) Srimoyee Dasgupta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Porous chitosan-MnO2nanohybrid: a green and biodegradable heterogeneous catalyst for aerobic oxidation of alkylarenes and alcohols

(2015) Ahmad Shaabani et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties

(2015) Philip Redpath et al.   CARBOHYDRATE RESEARCH

Catalytic amounts of CBr4 mediated dehydrogenative coupling of isochromans with aromatic ketones

(2015) Congde Huo et al.   CHEMICAL COMMUNICATIONS

Activation of CH Bonds through Oxidant-Free Photoredox Catalysis: Cross-Coupling Hydrogen-Evolution Transformation of Isochromans and β-Keto Esters

(2015) Ming Xiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Facile synthesis of phthalan derivatives via a Pd-catalyzed tandem hydroalkynylation, isomerization, Diels–Alder cycloaddition and aromatization reaction

(2015) Ru-Wei Shen et al.   CHINESE CHEMICAL LETTERS

Synthesis and Acid-Catalyzed Cyclization of 2-Alkenylstilbenes: a New Approach to the Substituted Indenes

(2015) Wei Ding et al.   CHINESE JOURNAL OF CHEMISTRY

Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors

(2015) Jiewen Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Eco-Friendly Route toN-Arylindoles by Iron-Catalyzed [2+2+2] Cycloaddition of Diynes with (Indol-1-yl)alkynes

(2015) Hrishikesh Chowdhury et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cyclocarbonylative Sonogashira Reactions of 1-Ethynylbenzyl Alcohols: Synthesis of 1-Carbonylmethylene-1,3-Dihydroisobenzofurans

(2015) Laura Antonella Aronica et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and antioxidant evaluation of isochroman-derivatives of hydroxytyrosol: Structure–activity relationship

(2015) Raquel Mateos et al.   FOOD CHEMISTRY

Radical scavenging activity characterization of synthetic isochroman-derivatives of hydroxytyrosol: A gas-phase DFT approach

(2015) Nikolaos Nenadis et al.   FOOD RESEARCH INTERNATIONAL

Synthesis of five- and six-membered heterocycles by dimethyl carbonate with catalytic amounts of nitrogen bicyclic bases

(2015) F. Aricò et al.   GREEN CHEMISTRY

Copper Mediated Formation of Carbon-Heteroatom Bonds Using Organoboron Reagents and Ultrasound

(2015) George W. Kabalka et al.   HETEROCYCLES

Long lasting perfume – A review of synthetic musks in WWTPs

(2015) Vera Homem et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Stereoselective Synthesis of Substituted Tetrahydropyrans and Isochromans by Cyclization of Phenylseleno Alcohols

(2015) Andrea Temperini et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Copper-Catalyzed Alkynylation of Benzopyranyl Oxocarbenium Ions

(2015) Harathi D. Srinivas et al.   JOURNAL OF ORGANIC CHEMISTRY

Evaluating the Effect of Catalyst Nuclearity in Ni-Catalyzed Alkyne Cyclotrimerizations

(2015) Sudipta Pal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Phenolic Compounds by Trapping Arynes with a Hydroxy Surrogate

(2015) Rajdip Karmakar et al.   MOLECULES

Six new metabolites produced byColletotrichum aotearoa09F0161, an endophytic fungus isolated fromBredia oldhamii

(2015) Yi Hsiao et al.   NATURAL PRODUCT RESEARCH

P-stereogenic PNP pincer-Pd catalyzed intramolecular hydroamination of amino-1,3-dienes

(2015) Zehua Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Aerobic Oxidation of Benzylic sp3 C–H Bonds of Ethers and Alkylarenes Promoted by a Recyclable TEMPO Catalyst

(2015) Zhiguang Zhang et al.   ORGANIC LETTERS

Hydroboration of Arynes Formed by Hexadehydro-Diels–Alder Cyclizations with N-Heterocyclic Carbene Boranes

(2015) Takashi Watanabe et al.   ORGANIC LETTERS

Efficient C(sp3)–H Bond Functionalization of Isochroman by AZADOL Catalysis

(2015) Wataru Muramatsu et al.   ORGANIC LETTERS

Direct ortho-C–H Functionalization of Aromatic Alcohols Masked by Acetone Oxime Ether via exo-Palladacycle

(2015) Kun Guo et al.   ORGANIC LETTERS

Synthesis of Functionalized 1H-Isochromene Derivatives via a Au-Catalyzed Domino Cycloisomerization/Reduction Approach

(2015) Eder Tomás-Mendivil et al.   ORGANIC LETTERS

Isochroman and isocoumarin derivatives from hypersaline lake sediment-derived fungus Penicillium sp.

(2015) Raha S. Orfali et al.   Phytochemistry Letters

Facile Approach for C(sp3)–H Bond Thioetherification of Isochroman

(2015) Chun Cai et al.   SYNLETT

A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives

(2015) Hu Chen et al.   TETRAHEDRON

Nickel-catalyzed cycloaddition of methyleneaziridines with diynes to synthesize fused anilines

(2015) Xiaodong Lu et al.   TETRAHEDRON LETTERS

Hydroxy group directed stereochemistry in oxypalladation of chiral allylic alcohol

(2015) Akiko Ida et al.   TETRAHEDRON LETTERS

Synthesis of phthalides from bis-propargyl ethers: use of Garratt–Braverman cyclization to construct the phthalans and IBX as a new reagent for subsequent oxidation

(2015) Arpita Panja et al.   TETRAHEDRON LETTERS

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

(2015) Bich Anh Chau et al.   MedChemComm

Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction–cyclization (HRC) reactions

(2015) Jonnada Krishna et al.   RSC Advances

Selective formation of C–N and CN bonds via C(sp3)–H activation of isochroman in the presence of DTBP

(2015) J. Feng et al.   Organic Chemistry Frontiers

Palladium nanoparticles in glycerol: a clear-cut catalyst for one-pot multi-step processes applied in the synthesis of heterocyclic compounds

(2015) Faouzi Chahdoura et al.   Organic Chemistry Frontiers

Synthesis of DihydroisobenzofuransviaPalladium-Catalyzed Sequential Alkynylation/Annulation of 2-Bromobenzyl and 2-Chlorobenzyl Alcohols under Microwave Irradiation

(2014) Eduardo Buxaderas et al.   ADVANCED SYNTHESIS & CATALYSIS

Anion-Binding Catalysis by Electron-Deficient Pyridinium Cations

(2014) Albrecht Berkessel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Easily Accessible Auxiliary for Palladium-Catalyzed Intramolecular Amination of C(sp2)H and C(sp3)H Bonds at δ- and ε-Positions

(2014) Chao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimetic Synthesis of the Calcineurin Phosphatase Inhibitor Dibefurin

(2014) Pascal Ellerbrock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

(2014) Jing Ren et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Iron-Catalyzed Alkenylation of Isochroman Acetals with Simple Alkenes

(2014) Bo Qian et al.   ChemCatChem

Direct access to isoindolines through tandem Rh(iii)-catalyzed alkenylation and cyclization of N-benzyltriflamides

(2014) Neeraj Kumar Mishra et al.   CHEMICAL COMMUNICATIONS

Enantioselective intramolecular propargylic amination using chiral copper–pybox complexes as catalysts

(2014) Masashi Shibata et al.   CHEMICAL COMMUNICATIONS

Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis

(2014) Raju Karmakar et al.   CHEMICAL REVIEWS

Microwave-Assisted Tandem Organocatalytic Peptide-Coupling Intramolecular aza-Michael Reaction: α,β-UnsaturatedN-Acyl Pyrazoles as Michael Acceptors

(2014) María Sánchez-Roselló et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-Alkylideneisochromans by Cyclocarbonylative Sonogashira Reactions

(2014) Laura Antonella Aronica et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Rhodium-NHC Hybrid Silica Materials as Recyclable Catalysts for [2+2+2] Cycloaddition Reactions of Alkynes

(2014) Martí Fernández et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Antimicrobial constituents from the flowers ofTrollius chinensis

(2014) Dan-Yi Li et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Isochromans and α-Pyrones from Penicillium corylophilum

(2014) David R. McMullin et al.   JOURNAL OF NATURAL PRODUCTS

A Tandem Reaction of Benzyne with Functionalized Benzylidenephthalan To Afford Phenanthro[10,1-bc]furan

(2014) Hai Xiao Siyang et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Hydroamination of Unactivated Olefins Using a Co Catalyst for Complex Molecule Synthesis

(2014) Hiroki Shigehisa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Terminal Olefins to Chromans, Isochromans, and Pyrans via Allylic C–H Oxidation

(2014) Stephen E. Ammann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dehydrogenative α-Oxygenation of Ethers with an Iron Catalyst

(2014) Angela Gonzalez-de-Castro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of two series of isoindolines over HDAC8 activity and expression

(2014) Cynthia R. Trejo Muñoz et al.   MEDICINAL CHEMISTRY RESEARCH

Secondary metabolites from Penicillium corylophilum isolated from damp buildings

(2014) David R. McMullin et al.   MYCOLOGIA

Phenazinium Salt-Catalyzed Aerobic Oxidative Amidation of Aromatic Aldehydes

(2014) Dasheng Leow   ORGANIC LETTERS

Organocatalytic Approach for C(sp3)–H Bond Arylation, Alkylation, and Amidation of Isochromans under Facile Conditions

(2014) Wataru Muramatsu et al.   ORGANIC LETTERS

Selective cyclization of alkynols and alkynylamines catalyzed by potassium tert-butoxide

(2014) Deng Yuan Li et al.   TETRAHEDRON

Formal hydrogenation of arynes with silyl Cβ–H bonds as an active hydride source

(2014) Phani Mamidipalli et al.   Chemical Science

Selective Catalytic Synthesis of Unsymmetrical Ethers from the Dehydrative Etherification of Two Different Alcohols

(2014) Junghwa Kim et al.   ACS Catalysis

Iron-catalyzed [2 + 2 + 2] cycloaddition of trifluoromethyl group substituted unsymmetrical internal alkynes

(2014) Maki Minakawa et al.   RSC Advances

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalysis by Neutral Multidentate Halogen-Bond Donors

(2013) Florian Kniep et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular C(sp3)N Coupling by Oxidation of Benzylic C,N-Dianions

(2013) Jenna L. Jeffrey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed Intramolecular Hydroamination of 1,3-Dienes to Give Homoallylic Amines

(2013) Justin M. Pierson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The chemistry of isoindole natural products

(2013) Klaus Speck et al.   Beilstein Journal of Organic Chemistry

1-Phenil-6,7-dihydroxy-isochroman inhibits inflammatory activation of microglia

(2013) Anna Rita Togna et al.   BRAIN RESEARCH BULLETIN

Iridium(III)-Catalyzed Approach for the Synthesis of Fused Arenes: Access to Isoindolines, Indanes, and Dihydroisobenzofurans

(2013) Anne-Laure Auvinet et al.   ChemCatChem

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

(2013) Ping-Xin Zhou et al.   CHEMICAL COMMUNICATIONS

Base-Dependent Stereodivergent Intramolecular Aza-Michael Reaction: Asymmetric Synthesis of 1,3-Disubstituted Isoindolines

(2013) Santos Fustero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

(2013) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tandem nucleophilic addition-intramolecular oxa-Michael reaction: Novel synthetic route to trifluoromethylated phthalans

(2013) Hongling Yuan et al.   JOURNAL OF FLUORINE CHEMISTRY

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

(2013) Yutong Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preparation of Polysubstituted Isochromanes by Addition of ortho-Lithiated Aryloxiranes to Enaminones

(2013) Antonio Salomone et al.   JOURNAL OF ORGANIC CHEMISTRY

Manganese Dioxide–Methanesulfonic Acid Promoted Direct Dehydrogenative Alkylation of sp3 C–H Bonds Adjacent to a Heteroatom

(2013) Xigong Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Phenolic extract obtained from steam-treated olive oil waste: Characterization and antioxidant activity

(2013) Fátima Rubio-Senent et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles

(2013) Avanashiappan Nandakumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solvent-Switched Benzylic Methylene Functionalization: Addition, Ring-Opening, Cyclization, and Unexpected Cleavage of C–O and C–C Bonds

(2013) Deng Yuan Li et al.   ORGANIC LETTERS

Dichlorination of (Hexadehydro-Diels–Alder Generated) Benzynes and a Protocol for Interrogating the Kinetic Order of Bimolecular Aryne Trapping Reactions

(2013) Dawen Niu et al.   ORGANIC LETTERS

Simple and Direct sp3 C–H Bond Arylation of Tetrahydroisoquinolines and Isochromans via 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Oxidation under Mild Conditions

(2013) Wataru Muramatsu et al.   ORGANIC LETTERS

Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoquinoline Derivatives

(2013) Santos Fustero et al.   ORGANIC LETTERS

Iron-Catalyzed Direct C(sp3)-H Amination Reactions of Isochroman Derivatives with Primary Arylamines under Mild Conditions

(2013) Jianguo Yang et al.   SYNLETT

Exploiting the Lithiation-Directing Ability of Oxetane for the Regioselective Preparation of Functionalized 2-Aryloxetane Scaffolds under Mild Conditions

(2012) Donato Ivan Coppi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combining Gold and Palladium Catalysis: One-Pot Access to Pentasubstituted Arenes from Furan-Yne and En-Diyne Substrates

(2012) A. Stephen K. Hashmi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Practical and Efficient Iridium Catalysis for Benzannulation: An Entry To Isoindolines

(2012) Anne-Laure Auvinet et al.   ChemSusChem

A new isobenzofuranone derivative from a marine Streptomyces sp.

(2012) Ze Ping Xie et al.   CHINESE CHEMICAL LETTERS

Convenient Synthesis of 1-Aryl-dihydroxyisochromans Exhibiting Antioxidant Activity

(2012) Roberta Bernini et al.   CURRENT ORGANIC CHEMISTRY

Synthesis and catalytic activity of heterogeneous rare-earth metal catalysts coordinated with multitopic Schiff-base ligands

(2012) Yilin Sun et al.   DALTON TRANSACTIONS

Flavimycins A and B, Dimeric 1,3-Dihydroisobenzofurans with Peptide Deformylase Inhibitory Activity from Aspergillus flavipes

(2012) Yun-Ju Kwon et al.   JOURNAL OF NATURAL PRODUCTS

Partition coefficient determination of a series of isoindolines-2-substituted and its correlation with their antiproliferative activity on HeLa cells

(2012) Cynthia R. Trejo Muñoz et al.   MEDICINAL CHEMISTRY RESEARCH

A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

(2012) Ke Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dynamic Kinetic Resolution of 1,3-Dihydro-2H-isoindole-1-carboxylic Acid Methyl Ester: Asymmetric Transformations toward Isoindoline Carbamates

(2012) Roberto Morán-Ramallal et al.   ORGANIC LETTERS

Phosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol

(2012) Yi Chiao Fan et al.   ORGANIC LETTERS

Alkaline Earth Catalysis of Alkynyl Alcohol Hydroalkoxylation/Cyclization

(2012) Christine Brinkmann et al.   ORGANOMETALLICS

Organothorium-Catalyzed Hydroalkoxylation/Cyclization of Alkynyl Alcohols. Scope, Mechanism, and Ancillary Ligand Effects

(2012) Stephen D. Wobser et al.   ORGANOMETALLICS

An Acid-Catalysed Hydroamination Approach to Isoindolines

(2012) David Knight et al.   SYNLETT

Convenient MCRs Synthesis of Trifluoromethylated Pyrano[4,3-b]pyrans and Their Further Transformation

(2012) Liping Song et al.   SYNTHESIS-STUTTGART

Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

(2012) Paul Hanson et al.   SYNTHESIS-STUTTGART

Bioactive polyketides from the sea fan-derived fungus Penicillium citrinum PSU-F51

(2012) Nanthaphong Khamthong et al.   TETRAHEDRON

Oxidation of benzylic methylenes to ketones with Oxone–KBr in aqueous acetonitrile under transition metal free conditions

(2012) Lixia Yin et al.   TETRAHEDRON LETTERS

Intramolecular Hydroalkoxylation and Hydroamination of Alkynes Catalyzed by Cu(I) Complexes Supported by N-Heterocyclic Carbene Ligands

(2012) Mark J. Pouy et al.   ACS Catalysis

Synthesis of a Unique Isoindoline/Tetrahydroisoquinoline-based Tricyclic Sultam Library Utilizing a Heck-aza-Michael Strategy

(2012) Qin Zang et al.   ACS Combinatorial Science

PdII-Catalyzed CH Olefination of N-(2-Pyridyl)sulfonyl Anilines and Arylalkylamines

(2011) Alfonso García-Rubia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines

(2011) Tomohiko Ohwada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors

(2011) Michael Shultz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1-Phenyl-6,7-dihydroxy-isochroman suppresses lipopolysaccharide-induced pro-inflammatory mediator production in human monocytes

(2011) Giuliana Trefiletti et al.   BRITISH JOURNAL OF NUTRITION

Catalyzed Selective Direct α- and γ-Alkylation of Aldehydes with Cyclic Benzyl Ethers by Using T+BF4− in the Presence of an Inexpensive Organic Acid or Anhydride

(2011) Heinrich Richter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Oxacycles Employing the Oxa-Pictet-Spengler Reaction: Recent Developments and New Prospects

(2011) Enrique L. Larghi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

5-Membered N-heterocyclic compounds by dimethyl carbonate chemistry

(2011) Fabio Aricò et al.   GREEN CHEMISTRY

Structure–Activity Relationship Studies on Isoindoline Inhibitors of Dipeptidyl Peptidases 8 and 9 (DPP8, DPP9): Is DPP8-Selectivity an Attainable Goal?

(2011) Sebastiaan Van Goethem et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Arylation of Isochroman

(2011) Soo J. Park et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper(II)-Catalyzed Asymmetric Henry Reaction ofo-Alkynylbenzaldehydes Followed by Gold(I)-Mediated Cycloisomerization: An Enantioselective Route to Chiral 1H-Isochromenes and 1,3-Dihydroisobenzofurans

(2011) Dengfu Lu et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions

(2011) Gang He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrated Catalytic C−H Transformations for One-Pot Synthesis of 1-Arylisoindoles from Isoindolines via Palladium-Catalyzed Dehydrogenation Followed by C−H Arylation

(2011) Toshimichi Ohmura et al.   ORGANIC LETTERS

A Garratt–Braverman route to aryl naphthalene lignans

(2011) Sayantan Mondal et al.   TETRAHEDRON LETTERS

Tandem Henry/oxa-Michael route to the 1,3-disubstituted-1,3-dihydrobenzo[c]furan system

(2011) Frederick A. Luzzio et al.   TETRAHEDRON LETTERS

A simple and efficient large-scale synthesis of 3-hydroxyphthalans via oxa-Pictet–Spengler reaction catalyzed by nanosilica sulfuric acid

(2011) Zahra Khorsandi et al.   TETRAHEDRON LETTERS

Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

(2011) Gang Chen et al.   MedChemComm

Oxidation and Amination of Benzylic sp3 C–H Bond Catalyzed by Rhenium(V) Complexes

(2011) Hao Peng et al.   ACS Catalysis

Enantioselective Synthesis of Isoindolines: An Organocatalyzed Domino Process Based On the aza-Morita-Baylis-Hillman Reaction

(2010) Shinobu Takizawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

(2010) Emmanuel Pinard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, fromAspergillus flavipesas an Inhibitor of Peptide Deformylase

(2010) Yun-Ju KWON et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Synthesis and Biological Properties of New 5-Cyano-1,1-disubstituted Phthalans for the Treatment of Premature Ejaculation

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid

(2010) Sébastien Bénard et al.   CHEMICAL COMMUNICATIONS

Application of an Enyne Metathesis/Diels-Alder Cycloaddition Sequence: A New Versatile Approach to the Syntheses of C-Aryl Glycosides and Spiro-C-Aryl Glycosides

(2010) Ayyagari V. Subrahmanyam et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reductive Ring-Opening of Phthalan and Isochroman: Application to the Stereoselective Synthesis of Tetrahydroisoquinolines and Tetrahydrobenzazepines

(2010) Daniel García et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Simple and Convenient High Yielding Synthesis of Substituted Isoindolines

(2010) Keith Smith et al.   HETEROCYCLES

Synthesis of Isochromans by Hydriodic Acid or Iodine Mediated Cyclization Reactions of 1-(2-Vinylphenyl)propan-2-ols

(2010) Kazuhiro Kobayashi et al.   HETEROCYCLES

Functionalised dithiocarbamate complexes: Complexes based on indoline, indole and substituted piperazine backbones – X-ray crystal structure of [Ni(S2CNC3H6C6H4)2]

(2010) Charalampos Anastasiadis et al.   INORGANICA CHIMICA ACTA

Substituted 4-Carboxymethylpyroglutamic Acid Diamides as Potent and Selective Inhibitors of Fibroblast Activation Protein

(2010) Ting-Yueh Tsai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular modeling study of isoindolines as L-type Ca2+ channel blockers by docking calculations

(2010) Teresa Mancilla-Percino et al.   JOURNAL OF MOLECULAR MODELING

A Simple and Mild Synthesis of 1H-Isochromenes and (Z)-1-Alkylidene-1,3-dihydroisobenzofurans by the Iodocyclization of 2-(1-Alkynyl)benzylic Alcohols

(2010) Raffaella Mancuso et al.   JOURNAL OF ORGANIC CHEMISTRY

Rearrangements and Intramolecular Diels−Alder Reactions of Normal and Vinylogous Aza-Morita−Baylis−Hillman Products Leading to Isoindoline Derivatives

(2010) Kristen N. Clary et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Synthesis of Either Isoindole- or Isoindoline-1-carboxylic Acid Esters by Pd(0)-Catalyzed Enolate Arylation

(2010) Daniel Solé et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed Hydroxyl-Directed C−H Olefination Enabled by Monoprotected Amino Acid Ligands

(2010) Yi Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formal [2 + 2 + 2] Cycloaddition Strategy Based on an Intramolecular Propargylic Ene Reaction/Diels−Alder Cycloaddition Cascade

(2010) Julia M. Robinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of (+)-Salvileucalin B

(2010) Sergiy Levin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-catalyzed [2+2+2] cycloaddition of various fluorine-containing alkynes—novel synthesis of multi-substituted fluoroalkylated aromatic compounds

(2010) Tsutomu Konno et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tandem Nucleophilic Addition−Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines

(2010) Santos Fustero et al.   ORGANIC LETTERS

Bismuth Triflate as a Safe and Readily Handled Source of Triflic Acid: Application to the Oxa–Pictet–Spengler Reaction

(2010) Benaissa Bouguerne et al.   SYNTHETIC COMMUNICATIONS

The isochroman- and 1,3-dihydroisobenzofuran-annulation on carbohydrate templates via [2+2+2]-cyclotrimerization and synthesis of some tricyclic nucleosides

(2010) Sharad B. Suryawanshi et al.   TETRAHEDRON

Furo[3,2-h]isochroman, furo[3,2-h]isoquinoline, isochroman, phenol, pyranone, and pyrone derivatives from the sea fan-derived fungus Penicillium sp. PSU-F40

(2010) Kongkiat Trisuwan et al.   TETRAHEDRON

From domino to multicomponent: synthesis of dihydroisobenzofurans

(2010) Monica Dell’Acqua et al.   TETRAHEDRON

Short synthesis of noscapine, bicuculline, egenine, capnoidine, and corytensine alkaloids through the addition of 1-siloxy-isobenzofurans to imines

(2010) Maria Del Pilar C. Soriano et al.   TETRAHEDRON LETTERS

Regioselective synthesis of phthalans via Cu(OTf)2-catalyzed 5-exo-dig intramolecular hydroalkoxylation of 2-(ethynyl)benzyl alcohols

(2010) Chandrasekaran Praveen et al.   TETRAHEDRON LETTERS

Stereochemical Control by an Ester Group or Olefin Ligand in Platinum-Catalyzed Carboalkoxylation of 6-(1-Alkoxyethoxy)- hex-2-ynoates

(2009) Itaru Nakamura et al.   ADVANCED SYNTHESIS & CATALYSIS

Cascade Reactions: Catalytic Synthesis of Functionalized 1,3-Dihydroisobenzofuran and Tetrahydrofuran Derivatives by Sequential Nucleophilic Ring Opening-Heterocyclization- Oxidative Carbonylation of Alkynyloxiranes

(2009) Nicola Della Ca' et al.   ADVANCED SYNTHESIS & CATALYSIS

Antioxidative activity of the olive oil constituent hydroxy-1-aryl-isochromans in cells and cell-free systems

(2009) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The antitumor effect of bromophenol derivatives in vitro and Leathesia nana extract in vivo

(2009) Dayong Shi et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic FungusPseudoanguillosporasp.

(2009) Ines Kock et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Facile Synthesis of 1,3-Dihydro- isobenzofurans Using Iodocylization of 2-Vinylbenzyl Alcohols

(2009) Kazuhiro Kobayashi et al.   HETEROCYCLES

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

(2009) Pei-Pei Kung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Synthesis of Enantiomerically Pure 2-Substituted Tetrahydro-3-benzazepines and Their Affinity to σ1Receptors

(2009) Syed Masood Husain et al.   JOURNAL OF ORGANIC CHEMISTRY

Lithiation ofN-Alkyl-(o-tolyl)aziridine: Stereoselective Synthesis of Isochromans§

(2009) Mariangela Dammacco et al.   JOURNAL OF ORGANIC CHEMISTRY

Oxidative Cleavage of Benzylic and Related Ethers, Using an Oxoammonium Salt

(2009) Priya P. Pradhan et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of (E)-3-(Isobenzofuran-3(1H)-ylidene)indolin-2-ones by the Palladium-Catalyzed Intramolecular C−H Functionalization Process

(2009) Peng Peng et al.   JOURNAL OF ORGANIC CHEMISTRY

C−F Bond Cleavage by Intramolecular SN2 Reaction of Alkyl Fluorides with O- and N-Nucleophiles

(2009) Laijun Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Photochemistry of benzene and quinoxaline fused Δ2-1,2,3-triazolines and their trapping products

(2009) Yu-Jen Chen et al.   TETRAHEDRON

A synthetic route to 1,3-dihydroisobenzofuran natural products: the synthesis of methyl ethers of pestacin

(2009) Raju Karmakar et al.   TETRAHEDRON LETTERS

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

(2008) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

(2008) Sebastiaan Van Goethem et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Organocatalytic Approach to Benzofused Nitrogen-Containing Heterocycles: Enantioselective Total Synthesis of (+)-Angustureine

(2008) Santos Fustero et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Oxa-Pictet–Spengler Reaction: A Highlight on the Different Efficiency between Isochroman and Phthalan or Homoisochroman Derivative Syntheses

(2008) Marcella Guiso et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Gold Catalysis and Chiral Sulfoxides: Enantioselective Synthesis of Dihydroisoindol-4-ols

(2008) A. Stephen K. Hashmi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Synthesis and Physical Properties of Novel Polyaromatic Profluorescent Isoindoline Nitroxide Probes

(2008) Kathryn E. Fairfull-Smith et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tandem Addition/Cyclization Reaction of Organozinc Reagents to 2-Alkynyl Aldehydes:  Highly Efficient Regio- and Enantioselective Synthesis of 1,3-Dihydroisobenzofurans and Tetrasubstituted Furans

(2008) Zhuo Chai et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions

(2008) Sarah E. Reisman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Hydroalkoxylation/Cyclization of Alkynyl Alcohols Mediated by Lanthanide Catalysts. Scope and Reaction Mechanism

(2008) SungYong Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An investigation on dihydroxy-isochromans in extra virgin olive oil

(2008) Marcella Guiso et al.   NATURAL PRODUCT RESEARCH

A [2 + 2 + 2]-Cycloaddition Approach toward 6-Oxa-allocolchicinoids with Apoptosis-Inducing Activity

(2008) Norman Nicolaus et al.   ORGANIC LETTERS

Hydroxy-1-aryl-isochromans: protective compounds against lipid peroxidation and cellular nitrosative stress

(2008) Michael Zeh et al.   REDOX REPORT

Regioselective reductive opening of substituted phthalans: synthetic applications

(2008) Daniel García et al.   TETRAHEDRON

A one-pot tandem oxidation–reduction protocol for the synthesis of cyclic ethers from their diols

(2008) Biswajit Panda et al.   TETRAHEDRON LETTERS

A very short asymmetric synthesis of enantiomerically pure methyl substituted tetrahydro-3-benzazepines

(2008) S. Masood Husain et al.   TETRAHEDRON-ASYMMETRY

Synthesis of Multisubstituted 2-(Dihydrofuran-2(3H)-ylidene)acetates via Intramolecular Carboalkoxylation by Platinum−Olefin Catalyst System

(2007) Itaru Nakamura et al.   ORGANIC LETTERS