Redox-Active Metal Complexes for Anticancer Therapy

In-Cell Activation of Organo-Osmium(II) Anticancer Complexes

(2016) Russell J. Needham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

(2016) V. Venkatesh et al.   DALTON TRANSACTIONS

Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery

(2016) Isabela Cristina Aguiar de Souza et al.   DALTON TRANSACTIONS

Metal-based drugs that break the rules

(2016) Claire S. Allardyce et al.   DALTON TRANSACTIONS

Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

(2016) Mun Juinn Chow et al.   Chemical Science

An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

(2015) Albert Gandioso et al.   CHEMICAL COMMUNICATIONS

Cobalt(III) Chaperone Complexes of Curcumin: Photoreduction, Cellular Accumulation and Light-Selective Toxicity towards Tumour Cells

(2015) Anna K. Renfrew et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Photoactivatable Platinum(IV) Anticancer Complex Conjugated to the RNA Ligand Guanidinoneomycin

(2015) Evyenia Shaili et al.   CHEMISTRY-A EUROPEAN JOURNAL

Advances in cobalt complexes as anticancer agents

(2015) Catherine R. Munteanu et al.   DALTON TRANSACTIONS

Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation

(2015) Isolda Romero-Canelón et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organoiridium Complexes: Anticancer Agents and Catalysts

(2014) Zhe Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts

(2014) Zhe Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cofactor metals and antioxidant enzymes in cisplatin-treated rats: effect of antioxidant intervention

(2014) Suna Sabuncuoglu et al.   DRUG AND CHEMICAL TOXICOLOGY

Development of anticancer agents: wizardry with osmium

(2014) Muhammad Hanif et al.   DRUG DISCOVERY TODAY

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly

(2014) Mun Juinn Chow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands

(2014) Zhe Liu et al.   ORGANOMETALLICS

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

Glutathione S-conjugates as prodrugs to target drug-resistant tumors

(2014) Emma E. Ramsay et al.   Frontiers in Pharmacology

Lawsone Dimerization in Cobalt(III) Complexes toward the Design of New Prototypes of Bioreductive Prodrugs

(2013) Francisco L. S. Bustamante et al.   INORGANIC CHEMISTRY

Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation

(2013) Isolda Romero-Canelón et al.   INORGANIC CHEMISTRY

The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway

(2013) Isolda Romero-Canelón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Competitive Binding Sites of a Ruthenium Arene Anticancer Complex on Oligonucleotides Studied by Mass Spectrometry: Ladder-Sequencing versus Top-Down

(2013) Kui Wu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study

(2013) Anna K. Renfrew et al.   Chemical Science

Redox activation of metal-based prodrugs as a strategy for drug delivery

(2012) Nora Graf et al.   ADVANCED DRUG DELIVERY REVIEWS

Organometallic Ruthenium and Iridium Transfer-Hydrogenation Catalysts Using Coenzyme NADH as a Cofactor

(2012) Soledad Betanzos-Lara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Reactions and Microbial Killing in the Neutrophil Phagosome

(2012) Christine C. Winterbourn et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Rhodium(III) and iridium(III) complexes as anticancer agents

(2012) Yvonne Geldmacher et al.   INORGANICA CHIMICA ACTA

Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex

(2012) Natsuho Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of New Scaffolds of Myeloperoxidase Inhibitors by Rational Design Combined with High-Throughput Virtual Screening

(2012) Iyas Aldib et al.   JOURNAL OF MEDICINAL CHEMISTRY

The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes

(2012) Ying Fu et al.   Chemical Science

Anticancer Activity of Metal Complexes: Involvement of Redox Processes

(2011) Ute Jungwirth et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity

(2011) Ying Fu et al.   DALTON TRANSACTIONS

Contrasting Reactivity and Cancer Cell Cytotoxicity of Isoelectronic Organometallic Iridium(III) Complexes

(2011) Zhe Liu et al.   INORGANIC CHEMISTRY

Organometallic Half-Sandwich Iridium Anticancer Complexes

(2011) Zhe Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metallo-salen complexes show promise towards treatment of leukemia

(2011) Subhrangsu S. Mandal   LEUKEMIA RESEARCH

Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands

(2011) Zhe Liu et al.   ORGANOMETALLICS

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

(2011) Steve D. Shnyder et al.   MedChemComm

A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light

(2010) Nicola J. Farrer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Platinum Chemotherapeutics

(2010) Benjamin W. Harper et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity

(2010) Ying Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of luminescent iridium(iii) polypyridine complexes as chemical and biological probes

(2010) Kenneth Kam-Wing Lo et al.   NEW JOURNAL OF CHEMISTRY

Redox Control of Asthma: Molecular Mechanisms and Therapeutic Opportunities

(2009) Suzy A.A. Comhair et al.   ANTIOXIDANTS & REDOX SIGNALING

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Redox-Regulated Mechanisms in Asthma

(2008) Tomoaki Hoshino et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation induced by the antioxidant glutathione (GSH)

(2008) Holm Petzold et al.   CHEMICAL COMMUNICATIONS

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY

Catalytic organometallic anticancer complexes

(2008) S. J. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electron-transfer activated metal-based anticancer drugs

(2006) Erwin Reisner et al.   INORGANICA CHIMICA ACTA