Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

(2016) Søren Fisker Schmidt et al.   Cell Reports

An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass

(2016) Suk Chon et al.   Diabetes & Metabolism Journal

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children

(2016) Jean-Claude Henquin et al.   PLoS One

Pancreatic beta cell lines and their applications in diabetes mellitus research

(2016) Masa Skelin   ALTEX-Alternatives to Animal Experimentation

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines

(2015) Bryndon J. Oleson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

GPR43 Potentiates β-Cell Function in Obesity

(2015) Joanne C. McNelis et al.   DIABETES

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets

(2015) Thierry Brun et al.   HUMAN MOLECULAR GENETICS

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

(2015) Rikard G. Fred et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exendin-4 protects rat islets against loss of viability and function induced by brain death

(2015) Rodrigo Carlessi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance andβ-Cell Dysfunction

(2015) Kevin Noel Keane et al.   Oxidative Medicine and Cellular Longevity

Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells

(2015) Alastair D. Green et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structural similarities and differences between the human and the mouse pancreas

(2015) Jurij Dolenšek et al.   Islets

Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells

(2015) G. A. Martens   Journal of Diabetes Research

A human beta cell line with drug inducible excision of immortalizing transgenes

(2015) Marion Benazra et al.   Molecular Metabolism

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line

(2015) Lotta E. Andersson et al.   PLoS One

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient regulation of insulin secretion and action

(2014) Philip Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

(2014) David J. Hodson et al.   MOLECULAR ENDOCRINOLOGY

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4

(2013) Srividya Vasu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

(2013) Srividya Vasu et al.   BIOLOGICAL CHEMISTRY

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl

(2013) D. Mokhtari et al.   DIABETOLOGIA

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Minireview: Intraislet Regulation of Insulin Secretion in Humans

(2013) Guy A. Rutter et al.   MOLECULAR ENDOCRINOLOGY

Differences in glucose-stimulated insulin secretionin vitroof islets from human, nonhuman primate, and porcine origin

(2013) Kate R Mueller et al.   XENOTRANSPLANTATION

Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia

(2013) Srividya Vasu et al.   Islets

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

(2012) C. Tang et al.   DIABETOLOGIA

Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity

(2012) N. Poungvarin et al.   DIABETOLOGIA

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

(2012) Hong Guo-Parke et al.   JOURNAL OF ENDOCRINOLOGY

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Islet microarchitecture and glucose transporter expression of the pancreas of the marmoset monkey display similarities to the human

(2012) Ruben R. Plentz et al.   Islets

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion

(2011) Jane T. McCluskey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Finally! A human pancreatic β cell line

(2011) Gordon C. Weir et al.   JOURNAL OF CLINICAL INVESTIGATION

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation

(2011) Daisuke Yabe et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

(2010) H. E. Levitt et al.   DIABETOLOGIA

The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes

(2010) Stanley Misler   Islets

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA