Review
Biochemistry & Molecular Biology
Flavia Urbano, Ilaria Farella, Giacomina Brunetti, Maria Felicia Faienza
Summary: Type 1 diabetes is a common chronic disease in childhood with increasing incidence. The management of T1D requires lifelong insulin treatment and continuous healthcare support. Automated insulin delivery systems, such as continuous subcutaneous insulin infusion combined with continuous glucose monitoring, have improved metabolic control and quality of life for T1D patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Elizabeth S. Keiner, James C. Slaughter, Karishma A. Datye, Alan D. Cherrington, Daniel J. Moore, Justin M. Gregory
Summary: COVID-19 infection in pediatric patients with type 1 diabetes is associated with lower tissue glucose disposal during standardized therapy for diabetic ketoacidosis (DKA), suggesting a metabolic derangement caused by COVID-19.
Article
Multidisciplinary Sciences
Asli Okan, Necdet Demir, Berna Sozen
Summary: Diabetes mellitus has profound effects on the female mammalian reproductive system and early embryonic development, mainly by triggering ER-stress induced apoptotic cascade. This study provides new insights into understanding the pathological effects of diabetes on ovarian function and early embryo development.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Giuseppe Loffredo, Luca Rinaldi, Christian Catalini, Klodian Gjeloshi, Gaetana Albanese, Anna Di Martino, Giovanni Docimo, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic patients are often affected by coronary microvascular dysfunction, a complex condition whose pathogenesis involves hyperglycemia and insulin resistance. This dysfunction contributes to cardiac events and heart failure, and no specific treatment exists. However, certain antidiabetic drugs may have protective effects.
Article
Endocrinology & Metabolism
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem
Summary: Diabetic nephropathy is a common microvascular complication in type 1 diabetes mellitus. Urinary markers of renal damage or oxidative stress may signal early stages of DN, but their association with blood pressure patterns and glycemic variability in children is not yet well understood. This study found that while microalbuminuria was negative, urinary NGAL/Cr and pentosidine/Cr ratios were significantly elevated in diabetic patients. Additionally, poor nocturnal systolic blood pressure dipping was found in nearly half of the cases, and urinary NGAL/Cr negatively correlated with this dipping pattern. Both NGAL/Cr and pentosidine/Cr ratios were also higher in the high glycemic variability group. Overall, this pilot study highlights the potential role of ABPM and urinary markers in the early detection of diabetic nephropathy, with glycemic variability possibly playing a role in the disease process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Mark A. Sperling, Lori M. Laffel
Summary: A 12.5-year-old pubertal girl is referred to a tertiary medical center for management of new-onset diabetes mellitus. The initial evaluation reveals glucosuria but no ketonuria. She has no family history of type 1 diabetes mellitus and her physical examination is normal except for Tanner stage 3 breast and pubic hair development.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Physical
Jiyong Kim, Salman Khan, Eun Kyu Kim, Hye-Jun Kil, Bo Min Kang, Hyo Geon Lee, Jin-Woo Park, Jun Young Yoon, Woochul Kim
Summary: Continuous monitoring and timely treatment are crucial for wearable and implantable healthcare systems, but they require continuous power supply. We developed a continuous healthcare system for type 1 diabetes by combining a low-energy micropump, self-powered glucose sensor, and body heat conversion to electricity. This system can provide true continuous healthcare for patients.
Review
Biochemistry & Molecular Biology
Stephen T. O'Brien, Orla M. Neylon, Timothy O'Brien
Summary: Cardiovascular disease is the leading cause of death in Type 1 Diabetes, with the molecular basis for atherosclerosis heavily influenced by hyperglycaemia. Current tools for assessing CVD risk in Type 1 Diabetes patients are limited, posing challenges for selecting appropriate lipid-lowering therapies. Best practice guidance for managing dyslipidaemia in Type 1 Diabetes is mainly based on evidence from Type 2 Diabetes patients and expert opinions.
Review
Endocrinology & Metabolism
Leigh Perreault, Jay S. Skyler, Julio Rosenstock
Summary: The article discusses the development of new drugs for type 2 diabetes mellitus (T2DM) and emphasizes their mechanisms of action and potential for treating T2DM. The number of clinical trials is increasing, providing more personalized and safe treatment options for T2DM patients.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Review
Immunology
Mei-Ling Yang, Richard G. Kibbey, Mark J. Mamula
Summary: This article summarizes the potential pathological consequences of posttranslational protein modifications (PTMs) and their associated biomarkers in the autoimmune disease type 1 diabetes (T1D), as well as the preventive and therapeutic approaches targeting PTMs to restore normal metabolic pathways in pancreatic islets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Alice L. J. Carr, Carmella Evans-Molina, Richard A. Oram
Summary: The personalised approach to diabetes care has evolved over time, incorporating personalised diagnosis, treatment, prevention, and prediction. Advances in understanding diabetes pathogenesis and human biology have improved diabetes care and hold promise for future precision medicine.
Review
Cardiac & Cardiovascular Systems
Jaume Padilla, Camila Manrique-Acevedo, Luis A. Martinez-Lemus
Summary: Insulin resistance is a hallmark of type 2 diabetes, leading to blunting of insulin-induced vasodilation. Impaired vasodilation results in reduced glucose uptake and contributes to impaired glucose control in diabetes. Understanding the mechanisms of insulin resistance is crucial for the development of diabetes and cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Daniel J. Drucker
Summary: Scientific advancements in the treatment of type 1 diabetes have seen significant progress in recent decades. Innovations such as newer insulin analogues, smart insulins, oral and weekly insulins, as well as strategies for human beta cell replacement and immune manipulation, have potential to improve quality of life for patients.
Review
Pediatrics
Brynn E. Marks, Joseph I. Wolfsdorf
Summary: This article reviews recent developments in methods used to monitor paediatric type 1 diabetes, with a focus on the importance of glucose and ketone monitoring, particularly continuous glucose monitoring (CGM). CGM is now considered the optimal method for monitoring glucose concentrations and should be introduced soon after diagnosis of type 1 diabetes. Comprehensive education and training are necessary for patients and healthcare providers to utilize and interpret the data provided by CGM.
CURRENT OPINION IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Atharva Kale, Natasha M. Rogers, Kedar Ghimire
Summary: Research on the TSP1-CD47 signaling pathway has shown its involvement in diseases affecting renal, vascular, metabolic function, and cancer. Despite significant progress in understanding this pathway in malignant and cardiovascular disease, there are still gaps in knowledge and translation regarding its role in kidney and metabolic diseases, which limits the identification of potential drug targets and the development of effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Srividya Vasu, Kenjiro Kumano, Carly M. Darden, Irum Rahman, Michael C. Lawrence, Bashoo Naziruddin
Article
Gastroenterology & Hepatology
Kenjiro Kumano, Morihito Takita, Srividya Vasu, Carly Darden, Michael Lawrence, Ernest Beecherl, Amar Gupta, Nicholas Onaca, Bashoo Naziruddin
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2020)
Article
Immunology
Kenjiro Kumano, Srividya Vasu, Yang Liu, Su-Tang Lo, Aditi Mulgaonkar, Jenelle Pennington, Carly M. Darden, Xiankai Sun, Michael C. Lawrence, Bashoo Naziruddin
Article
Pharmacology & Pharmacy
Dipak Sarnobat, Charlotte R. Moffett, Neil Tanday, Frank Reimann, Fiona M. Gribble, Peter R. Flatt, Andrei I. Tarasov
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Galyna Graham, J. Michael Conlon, R. Charlotte Moffett, Yasser H. Abdel-Wahab, Peter R. Flatt
Summary: The study showed that long-acting, dual-agonist anti-diabetic peptides can induce alpha-cell to beta-cell transdifferentiation, leading to increased pancreatic insulin content and plasma insulin concentrations. This suggests therapeutic potential for using proglucagon-derived peptides from phylogenetical ancient fish in diabetes treatment.
JOURNAL OF PEPTIDE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Kenjiro Kumano, Mazhar A. Kanak, Prathab Balaji Saravanan, J. P. Blanck, Yang Liu, Srividya Vasu, Michael Lawrence, Bashoo Naziruddin
Summary: Withaferin A may reduce inflammation and prolong allograft survival by inhibiting dendritic cell maturation and T-cell proliferation.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
D. Sarnobat, R. C. Moffett, P. R. Flatt, A. I. Tarasov
Summary: The study showed that metformin and rosiglitazone can help slow down the reduction of beta-cell pool in streptozotocin-induced diabetes, while tolbutamide may exacerbate beta-cell apoptosis but potentially protect beta-cells from chronic hyperglycemia by increasing insulin secretion directly.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Endocrinology & Metabolism
Jordan Mattke, Srividya Vasu, Carly M. M. Darden, Kenjiro Kumano, Michael C. C. Lawrence, Bashoo Naziruddin
Summary: Exosomes play a crucial role in studying diagnostic markers for islet cell viability and function in islet transplantation. They may have an impact on the success of islet transplantation and could potentially be used as a therapeutic tool.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Prawej Ansari, Peter R. Flatt, Patrick Harriott, J. M. A. Hannan, Yasser H. A. Abdel-Wahab
Summary: The study demonstrated the antidiabetic effects of Acacia arabica bark extract, showing potential as a treatment for diabetes. The isolated phytoconstituents, including quercetin and kaempferol, improved glucose tolerance and insulin secretion, indicating the benefits of using them as antidiabetic agents.
Article
Gastroenterology & Hepatology
Yang Liu, Srividya Vasu, Kenjiro Kumano, Jeffrey A. SoRelle, Michael C. Lawrence, Bashoo Naziruddin
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Multidisciplinary Sciences
Carly M. Darden, Srividya Vasu, Jordan Mattke, Yang Liu, Christopher J. Rhodes, Bashoo Naziruddin, Michael C. Lawrence
Summary: The study reveals that calcineurin and PI3K/AKT signaling pathways play important roles in maintaining beta-cell function, but prolonged exposure to stress or perturbation of these pathways may lead to beta-cell dedifferentiation and dysfunction.
Article
Medicine, Research & Experimental
Julie Turbitt, Lorraine Brennan, R. Charlotte Moffett, Peter R. Flatt, Paul R. V. Johnson, Andrei I. Tarasov, Neville H. McClenaghan
Summary: The study found that taurine, alanine, and proline can promote insulin secretion through the regulation of ion transport and inhibition of the sodium-potassium-chloride cotransporter. This action of taurine may have potential value in the treatment of diabetes.
Article
Cell & Tissue Engineering
Srividya Vasu, Jiemin M. Yang, James Hodges, Maisam A. Abu-El-Haija, David B. Adams, Appakalai N. Balamurugan, Greg J. Beilman, Srinath Chinnakotla, Darwin L. Conwell, Martin L. Freeman, Timothy B. Gardner, Betul Hatipoglu, Varvara Kirchner, Luis F. Lara, Katherine A. Morgan, Jaimie D. Nathan, Andrew Posselt, Timothy L. Pruett, Sarah J. Schwarzenberg, Vikesh K. Singh, Martin Wijkstrom, Piotr Witkowski, Bashoo Naziruddin, Melena D. Bellin
Summary: The study investigated the associations between circulating miRNAs and patient, disease, and islet isolation characteristics in TPIAT patients. The results revealed different miRNAs were associated with genetic risk, toxic/metabolic diseases, exocrine insufficiency, and islet autotransplant outcomes.
CELL TRANSPLANTATION
(2021)
Article
Cell & Tissue Engineering
Gumpei Yoshimatsu, Mazhar A. Kanak, Srividya Vasu, Kenjiro Kumano, Michael Lawrence, Nicholas Onaca, Morihito Takita, Marlon F. Levy, Bashoo Naziruddin
CELL TRANSPLANTATION
(2020)