Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy

(2012) Anna Sliwa et al.   NEUROSCIENCE LETTERS

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

Validation of the rat model of cryptogenic infantile spasms

(2011) Tamar Chachua et al.   EPILEPSIA

Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

(2011) C. Nicole Sunnen et al.   EPILEPSIA

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations

(2011) Michael Wong   EXPERIMENTAL NEUROLOGY

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex

(2011) S. Anderl et al.   HUMAN MOLECULAR GENETICS

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Predicting PTEN mutations: an evaluation of Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome clinical features

(2011) R. Pilarski et al.   JOURNAL OF MEDICAL GENETICS

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

(2011) Emmanuel Raffo et al.   NEUROBIOLOGY OF DISEASE

Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex

(2011) Carlos Cepeda et al.   NEUROBIOLOGY OF DISEASE

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

(2011) J. Goto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

Rapamycin for Treatment of Epilepsy: Antiseizure, Antiepileptogenic, Both, or Neither?

(2011) Michael Wong   Epilepsy Currents

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

The underlying etiology of infantile spasms (West syndrome): Information from the United Kingdom Infantile Spasms Study (UKISS) on contemporary causes and their classification2

(2010) John P. Osborne et al.   EPILEPSIA

Modeling new therapies for infantile spasms

(2010) Lenka Chudomelova et al.   EPILEPSIA

Infantile spasms: A U.S. consensus report

(2010) John M. Pellock et al.   EPILEPSIA

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex

(2010) L.-H. Zeng et al.   HUMAN MOLECULAR GENETICS

STRADα deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

(2010) Ksenia A. Orlova et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

(2010) Darcy A. Krueger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer

(2010) J. J. Wallin et al.   Science Translational Medicine

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

(2009) M. C. Ljungberg et al.   Disease Models & Mechanisms

The natural history of epilepsy in tuberous sclerosis complex

(2009) Catherine J. Chu-Shore et al.   EPILEPSIA

Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: A critical review and the UCLA experience

(2009) Jason T. Lerner et al.   EPILEPSIA

Focal brain malformations: Seizures, signaling, sequencing

(2009) Peter B. Crino   EPILEPSIA

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

Early control of seizures improves long-term outcome in children with tuberous sclerosis complex

(2009) Roberta Bombardieri et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

A model of symptomatic infantile spasms syndrome

(2009) Morris H. Scantlebury et al.   NEUROBIOLOGY OF DISEASE

Increased frequency of distinctTSC2allelic variants in focal cortical dysplasias with balloon cells and mineralization

(2009) Anna Schönberger et al.   NEUROPATHOLOGY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Neurofibromatosis type 1 and infantile spasms

(2008) Martino Ruggieri et al.   CHILDS NERVOUS SYSTEM

A retrospective study on aetiology based outcome of infantile spasms

(2008) Georges Karvelas et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Proteus syndrome associated with hemimegalencephaly and Ohtahara syndrome: Report of two cases

(2007) Halisson Bastos et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY