Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects

(2013) John E. Casida et al.   Annual Review of Entomology

Advantages of an antagonist: bicuculline and other GABA antagonists

(2013) Graham AR Johnston   BRITISH JOURNAL OF PHARMACOLOGY

γ-Amino-butyric acid (GABA) receptor subunit and transporter expression in the gonad and liver of the fathead minnow (Pimephales promelas)

(2013) Katie Biggs et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Expression and distribution of GABA and GABAB-receptor in the rat adrenal gland

(2013) Kanae Kato et al.   JOURNAL OF ANATOMY

Multisite Binding of a General Anesthetic to the Prokaryotic PentamericErwinia chrysanthemiLigand-gated Ion Channel (ELIC)

(2013) Radovan Spurny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of Neuroendocrine Stress Response by Glucocorticoid Receptor or GABAA Receptor Antagonists after Experimental Traumatic Brain Injury

(2013) Anna N. Taylor et al.   JOURNAL OF NEUROTRAUMA

Where will genetic toxicology testing be in 30 years’ time? Summary report of the 25th Industrial Genotoxicity Group Meeting, Royal Society of Medicine, London, November 9, 2011

(2013) Patricia Ellis et al.   MUTAGENESIS

Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys

(2013) Paul L Soto et al.   NEUROPSYCHOPHARMACOLOGY

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling

(2013) Miyuki Breen et al.   TOXICOLOGICAL SCIENCES

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: I. Data Generation in a Small Fish Model

(2013) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

(2012) Erwin Sigel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Advancing the Next Generation of Health Risk Assessment

(2012) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Modeling the Closed and Open State Conformations of the GABAA Ion Channel - Plausible Structural Insights for Channel Gating

(2012) R. S. K. Vijayan et al.   Journal of Chemical Information and Modeling

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

(2012) Lars Richter et al.   Nature Chemical Biology

Chemical toxins that cause seizures

(2012) David A. Jett   NEUROTOXICOLOGY

Different Subtypes of GABA-A Receptors Are Expressed in Human, Mouse and Rat T Lymphocytes

(2012) Suresh K. Mendu et al.   PLoS One

Classical Neurotransmitters and Neuropeptides Involved in Generalized Epilepsy: A Focus on Antiepileptic Drugs

(2011) F.-M. Werner et al.   CURRENT MEDICINAL CHEMISTRY

Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics

(2011) Natàlia Garcia-Reyero et al.   ECOTOXICOLOGY

Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats

(2011) Masahiro Tsuji et al.   EXPERIMENTAL NEUROLOGY

The GABAA Receptor  + - Interface: A Novel Target for Subtype Selective Drugs

(2011) J. Ramerstorfer et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data

(2011) Tommy Sander et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat

(2010) Cara M Hildreth et al.   BMC NEUROSCIENCE

RDX Binds to the GABA A Receptor–Convulsant Site and Blocks GABA A Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures

(2010) Larry R. Williams et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

An assessment of the developmental, reproductive, and neurotoxicity of endosulfan

(2009) Marilyn H. Silva et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Homology modeling of human α1β2γ2 and house fly β3 GABA receptor channels and Surflex-docking of fipronil

(2009) Jin Cheng et al.   JOURNAL OF MOLECULAR MODELING

The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat α1β2γ2L GABAA receptor

(2008) P Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Assembly of GABAAreceptors (Review)

(2008) Isabella Sarto-Jackson et al.   MOLECULAR MEMBRANE BIOLOGY

Structural Determinants for Antagonist Pharmacology That Distinguish the  1 GABAC Receptor from GABAA Receptors

(2008) J. Zhang et al.   MOLECULAR PHARMACOLOGY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

(2008) R. W. Olsen et al.   PHARMACOLOGICAL REVIEWS