Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms

Differing Species Responsiveness of Estrogenic Contaminants in Fish Is Conferred by the Ligand Binding Domain of the Estrogen Receptor

(2014) Shinichi Miyagawa et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

In Silico Analysis of the Conservation of Human Toxicity and Endocrine Disruption Targets in Aquatic Species

(2014) Fiona M. McRobb et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals

(2014) T. H. Hutchinson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology

(2014) A. R. Brown et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems

(2013) K. E. Arnold et al.   Biology Letters

Metabolic and Reproductive Effects of Relatively Low Concentrations of Beclomethasone Dipropionate, a Synthetic Glucocorticoid, on Fathead Minnows

(2013) Subramaniam Kugathas et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Several Synthetic Progestins with Different Potencies Adversely Affect Reproduction of Fish

(2013) Tamsin J. Runnalls et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Synthetic Progestin Levonorgestrel Is a Potent Androgen in the Three-Spined Stickleback (Gasterosteus aculeatus)

(2013) Johan Svensson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions

(2013) Kristin A. Connors et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

CROSS-SPECIES CONSERVATION OF ENDOCRINE PATHWAYS: A CRITICAL ANALYSIS OF TIER 1 FISH AND RAT SCREENING ASSAYS WITH 12 MODEL CHEMICALS

(2013) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Regulation of gonadal sex ratios and pubertal development by the thyroid endocrine system in zebrafish (Danio rerio)

(2013) Prakash Sharma et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Current perspectives on the androgen 5 alpha-dihydrotestosterone (DHT) and 5 alpha-reductases in teleost fishes and amphibians

(2013) Christopher J. Martyniuk et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Cytogenetic toxicity and gonadal effects of 17 α-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae)

(2013) C.L.G. Rivero-Wendt et al.   GENETICS AND MOLECULAR RESEARCH

Testosterone implants modify the steroid hormone balance and the gonadal physiology of gilthead seabream (Sparus aurata L.) males

(2013) Miriam Sánchez-Hernández et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Propiconazole Inhibits Steroidogenesis and Reproduction in the Fathead Minnow (Pimephales promelas)

(2013) Sarah Y. Skolness et al.   TOXICOLOGICAL SCIENCES

7α-Methyl-19-nortestosterone (MENTR): the Population Council's contribution to research on male contraception and treatment of hypogonadism

(2012) Eberhard Nieschlag et al.   CONTRACEPTION

Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?

(2012) Alistair B.A. Boxall et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows

(2012) Theodore W. Valenti et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of gemfibrozil on lipid metabolism, steroidogenesis, and reproduction in the fathead minnow (Pimephales promelas)

(2012) Sarah Y. Skolness et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of progesterone on reproduction and embryonic development in the fathead minnow (Pimephales promelas)

(2012) Zachary A. DeQuattro et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The effects of diclofenac on early life stages of common carp (Cyprinus carpio)

(2012) Stanislava Stepanova et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

ADMET Evaluation in Drug Discovery. 11. PharmacoKinetics Knowledge Base (PKKB): A Comprehensive Database of Pharmacokinetic and Toxic Properties for Drugs

(2012) Dongyue Cao et al.   Journal of Chemical Information and Modeling

Psychoactive Pharmaceuticals Induce Fish Gene Expression Profiles Associated with Human Idiopathic Autism

(2012) Michael A. Thomas et al.   PLoS One

Effects of progesterone on sperm motility in fathead minnow (Pimephales promelas)

(2011) Patrick J. Murack et al.   AQUATIC TOXICOLOGY

Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows

(2011) Melissa M. Schultz et al.   AQUATIC TOXICOLOGY

Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka

(2011) Jinyoung Lee et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Synthetic Glucocorticoids in the Environment: First Results on Their Potential Impacts on Fish

(2011) Subramaniam Kugathas et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Prioritizing contaminants of emerging concern for ecological screening assessments

(2011) Jerome M. Diamond et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development

(2011) Carlie A. LaLone et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Pharmaceuticals as Neuroendocrine Disruptors: Lessons Learned from Fish on Prozac

(2011) Jan A. Mennigen et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone

(2010) Peter Paulos et al.   AQUATIC TOXICOLOGY

Fish embryo toxicity of carbamazepine, diclofenac and metoprolol

(2010) Evert-Jan van den Brandhof et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Use of gene expression, biochemical and metabolite profiles to enhance exposure and effects assessment of the model androgen 17β-trenbolone in fish

(2010) Drew R. Ekman et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Behavioral and physiological responses of a wild teleost fish to cortisol and androgen manipulation during parental care

(2010) Cody J. Dey et al.   HORMONES AND BEHAVIOR

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: A mechanistic evaluation

(2009) Andrea Lister et al.   AQUATIC TOXICOLOGY

Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)

(2009) Liwei Sun et al.   AQUATIC TOXICOLOGY

Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas)

(2009) Emma Giltrow et al.   AQUATIC TOXICOLOGY

I. Effects of a dopamine receptor antagonist on fathead minnow, Pimephales promelas, reproduction

(2009) Daniel L. Villeneuve et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish

(2009) Daniel L. Villeneuve et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Simple, Rapid Zebrafish Larva Bioassay for Assessing the Potential of Chemical Pollutants and Drugs to Disrupt Thyroid Gland Function

(2009) Demetrio Raldúa et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

EFFECTS OF SYNTHETIC GESTAGENS ON FISH REPRODUCTION

(2009) Jana Zeilinger et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

ANTIDEPRESSANTS AT ENVIRONMENTALLY RELEVANT CONCENTRATIONS AFFECT PREDATOR AVOIDANCE BEHAVIOR OF LARVAL FATHEAD MINNOWS (PIMEPHALES PROMELAS)

(2009) Meghan M. Painter et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals

(2009) Jason P. Berninger et al.   TOXICOLOGY LETTERS

PK/DB: database for pharmacokinetic properties and predictive in silico ADME models

(2008) T. L. Moda et al.   BIOINFORMATICS

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor

(2008) Daniel L. Villeneuve et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Derivation of an Aquatic Predicted No-Effect Concentration for the Synthetic Hormone, 17α-Ethinyl Estradiol

(2008) Daniel J. Caldwell et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

REPRODUCTIVE TOXICITY OF VINCLOZOLIN IN THE FATHEAD MINNOW: CONFIRMING AN ANTI-ANDROGENIC MODE OF ACTION

(2008) Dalma Martinović et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)

(2007) Matthew J. Winter et al.   AQUATIC TOXICOLOGY

Risks to aquatic organisms posed by human pharmaceutical use

(2007) Mitchell S. Kostich et al.   SCIENCE OF THE TOTAL ENVIRONMENT