Article
Biochemistry & Molecular Biology
Debarshi Roy, Brenita Jenkins, Aqeeb Ali, Jacob R. Herschmann, Michele Harris, Matibur Zamadar, Laken Simington, Odutayo Odunuga, Prakash Adhikari, Prabhakar Pradhan, Sanjay Sarkar, Mahesh Pattabiram, Bidisha Sengupta
Summary: Ovarian cancer is a deadly gynecological cancer that often goes undetected until the advanced stage. A new study on photodynamic therapy has found that a drug combination can effectively inhibit the growth and induce cell death in drug-resistant and sensitive ovarian cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kenneth R. Olson, Kasey J. Clear, Paul J. Derry, Yan Gao, Zhilin Ma, Nathaniel M. Cieplik, Alyssa Fiume, Dominic J. Gaziano, Stephen M. Kasko, Kathleen Narloch, Cecilia L. Velander, Ifeyinwa Nwebube, Collin J. Pallissery, Ella Pfaff, Brian P. Villa, Thomas A. Kent, Gang Wu, Karl D. Straub
Summary: This study investigates the reaction mechanism of NQ oxidation of H2S to produce RSS using various experimental methods. The results show that NQ can oxidize H2S to per- and polysulfides, consuming oxygen and being accelerated by SOD while inhibited by catalase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Ange Mouithys-Mickalad, Nazare Storms, Thierry Franck, Justine Ceusters, Geoffroy de la Rebiere de Pouyade, Ginette Deby-Dupont, Didier Serteyn
Summary: Juglone inhibits equine laminitis by modulating neutrophil activation, and it also suppresses neutrophil degranulation and the peroxidase activity of MPO.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Parasitology
Ines Sifaoui, Eulalia Capote Yanes, Maria Reyes-Batlle, Ruben L. Rodriguez-Exposito, Isabel L. Bazzocchi, Ignacio A. Jimenez, Jose E. Pinero, Jacob Lorenzo-Morales, Lindell K. Weaver
Summary: Increasing oxygen concentrations can significantly reduce the growth of Acanthamoeba and increase ROS production, leading to growth inhibition due to oxidative stress. Further studies are needed to determine the level of oxygen saturation, exposure time, and number of sessions required to eliminate the parasite.
PARASITOLOGY RESEARCH
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Jiale Liu, Mengyao Huang, Xinyu Zhang, Zhongyu Hua, Zeran Feng, Yi Dong, Tiedong Sun, Xiao Sun, Chunxia Chen
Summary: The dual effects of reactive oxygen species (ROS) in living organisms, which can cause oxidative imbalances and be regulated to attack tumors and bacteria, have attracted significant research attention. Polyoxometalates (POMs) have shown great potential in modulating ROS and have been investigated for disease treatment and sensing diagnostics, providing valuable insights into therapeutic and diagnostic technologies.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Alvaro de Obeso Fernandez del Valle, Christian Quintus Scheckhuber
Summary: This article reviews the role of different SODs in the development and pathogenicity of various eukaryotic microorganisms, including fungi, Aspergillus spp., parasitic protozoa, and pathogenic amoebae. SODs play essential roles in these microorganisms, participating in processes such as development, host infection, propagation, and control of gene expression.
Article
Engineering, Biomedical
X. Huang, D. He, Z. Pan, G. Luo, J. Deng
Summary: ROS can mediate various physiological functions, but their over-accumulation can lead to premature aging or death, as well as inflammatory conditions. Advances in nanoscience have led to the development of nanomaterials with unique ROS-scavenging abilities, allowing for the emergence of next-generation strategies to ameliorate ROS-related inflammatory conditions. Ongoing studies and clinical applications of nanomedicine based on ROS scavenging stand to benefit from this interdisciplinary field.
MATERIALS TODAY BIO
(2021)
Review
Chemistry, Analytical
Xu Teng, Ling Qi, Tao Liu, Linhai Li, Chao Lu
Summary: This review summarizes the applications of nanomaterial-based chemiluminescence biosensors for tracing reactive oxygen species (ROS) in recent years. The selection of nanomaterials and the basic mechanism for selective detection of ROS were focused on. Thinking and predictions on exploring novel nanomaterial-based CL platforms were provided. This review may inspire new strategies for ROS tracing in biological environments. (c) 2023 Elsevier B.V. All rights reserved.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Environmental
Yuqin Lu, Hua Deng, Tingting Pan, Xu Liao, Changbin Zhang, Hong He
Summary: A simple strategy was provided to regulate the morphology and microstructure of (5-MnO2 via the hydrothermal reaction temperature, which improved the reactivity and lifetime of catalysts in the catalytic ozonation of toluene. The optimized MnO2-260 catalyst showed high catalytic activity and excellent stability at the approximately ambient temperature of 40 degrees C. Surface oxygen vacancy clusters, especially surface oxygen dimer vacancies, were found to be critical in ozone activation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ju Yup Lee, Kyung Sik Park, Hyun-Gyo Lee, Won-Ki Baek, Kwang Bum Cho, Yoo Jin Lee, Yoon Suk Lee, Seung-Wan Ryu
CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Article
Cell Biology
H-J Jung, I. Seo, F. Casciello, S. Jacquelin, S. W. Lane, S-Il Suh, M-H Suh, J. S. Lee, W-K Baek
CELL DEATH & DISEASE
(2016)
Article
Medicine, General & Internal
Seong Yeol Ryu, Won-Ki Baek, Hyun Ah Kim
KOREAN JOURNAL OF INTERNAL MEDICINE
(2017)
Review
Biochemistry & Molecular Biology
Kyunghee Lee, Incheol Seo, Mun Hwan Choi, Daewon Jeong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Neurosciences
Incheol Seo, Hyunsu Lee
BRAIN RESEARCH BULLETIN
(2019)
Article
Endocrinology & Metabolism
Jae-Hyung Park, Incheol Seo, Hae-Min Shim, Hochan Cho
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Oncology
Hui-Jung Jung, Incheol Seo, Bijay Jha, Seong-Il Suh, Won-Ki Baek
Summary: Miconazole, an antifungal agent, displays potent anticancer effects by inducing autophagic cell death in cancer cells, particularly in the U251MG glioblastoma cell line through ROS-dependent ER stress response. Inhibition of ER stress reduced miconazole-induced autophagy and cell death, suggesting a potential antiproliferative mechanism of miconazole in glioma cancer cells.
Article
Oncology
Incheol Seo, Hye Won Lee, Sang Jun Byun, Jee Young Park, Hyeonji Min, Sung Hwan Lee, Ju-Seog Lee, Shin Kim, Sung Uk Bae
Summary: The study found that neoadjuvant chemoradiation therapy (CRT) significantly enriched the immune response in locally advanced rectal cancer (LARC) tissues and affected related immunogenic effects. Furthermore, CRT can lead to downregulation of MMR system-related genes and an increase in tumor mutational burden and proportions of immune-related cells in LARC tissues.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell & Tissue Engineering
Jung Min Park, Mee Sook Jun, Jung-A. Kim, Nanda Maya Mali, Tsai-Ching Hsi, Areum Cho, Jung Chul Kim, Jun Young Kim, Incheol Seo, Jungmin Kim, Moonkyu Kim, Ji Won Oh
Summary: This study demonstrated that inflammatory factors induce the expression of major histocompatibility complex class I proteins in dermal papilla cells, and the loss of immune privilege of hair follicles can be rescued by treatment with conditioned media from outer root sheath cells. Transcriptomic analyses identified 58 up-regulated genes and 183 down-regulated genes related to MHC class I+ cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biology
Hyeong Chan Shin, Incheol Seo, Hasong Jeong, Sang Jun Byun, Shin Kim, Sung Uk Bae, Sun Young Kwon, Hye Won Lee
Summary: This study found a significant correlation between tumor-associated macrophages expressing CD68 and CD11c and distant metastasis as well as survival rates in colorectal cancer patients. CD11c-positive macrophages were identified as independent prognostic factors for overall survival. TAMs were shown to be significantly associated with long-term oncologic outcomes in CRC.
Article
Biochemistry & Molecular Biology
Su-Jeong Kim, Incheol Seo, Min Hee Kim, Joo-Won Park, Shin Kim, Woo-Jae Park
Summary: This study found that CerS4 is overexpressed in breast cancer, especially in the LumA subtype. Overexpression of CerS4 leads to activation of cancer-associated pathways, increased cell migration and epithelial-mesenchymal transition (EMT), and drug resistance in breast cancer cells. Therefore, CerS4 may represent an attractive target for breast cancer treatment.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Medicine, Research & Experimental
Incheol Seo, Hyunsoo Jang
Summary: The study found that pelvic radiotherapy in cervical cancer patients may increase anal bleeding and symptomatic hemorrhoids. The risk is particularly higher in patients who undergo chemotherapy and have diabetes. Attention is needed to prevent hemorrhoid worsening in patients with hemorrhoids undergoing pelvic radiotherapy.
Article
Medical Laboratory Technology
Incheol Seo, Ji-Hyoung Cho, Moo-Hyun Lee, Won-Jin Park, Sun-Young Kwon, Jae-Ho Lee
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Kun Moon, Hyun-Gyo Lee, Won-Ki Baek, Youngkyun Lee, Kwang Soo Kim, Jong Hwa Jun, Jae-Young Kim, Choun-Ki Joo
