Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability

Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia

(2012) Huimin Qiao et al.   BRAIN RESEARCH

Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-κB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

(2010) Lina Wang et al.   BRAIN RESEARCH

Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: Down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability

(2010) Lili Cui et al.   BRAIN RESEARCH

Methyleugenol reduces cerebral ischemic injury by suppression of oxidative injury and inflammation

(2010) Yoo Keum Choi et al.   FREE RADICAL RESEARCH

Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression

(2010) Lina Wang et al.   NEUROSCIENCE LETTERS

Baicalein is neuroprotective in rat MCAO model: Role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2

(2010) Lili Cui et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression

(2009) Ying Liu et al.   BRAIN RESEARCH

Genomewide Association Studies of Stroke

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-κB: neuroprotective implications

(2008) Kyong Nyon Nam et al.   NEUROPHARMACOLOGY