Modulation of Chemokine Responses: Synergy and Cooperativity

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses

(2016) Mark A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Overview and potential unifying themes of the atypical chemokine receptor family

(2016) Alessandro Vacchini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

“Chemokine receptors as therapeutic targets: Why aren’t there more drugs?”

(2015) Roberto Solari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation

(2015) Tiziana Adage et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization

(2015) Douglas P Dyer et al.   GLYCOBIOLOGY

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of atherosclerotic plaque inflammation

(2015) M. Bäck et al.   JOURNAL OF INTERNAL MEDICINE

Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking

(2015) Valentina Cecchinato et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

(2015) E. Kiermaier et al.   SCIENCE

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

(2015) Jean-Eric Alard et al.   Science Translational Medicine

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding

(2014) F. Verkaar et al.   JOURNAL OF IMMUNOLOGY

Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice

(2014) Waka Yokoyama et al.   ARTHRITIS RESEARCH & THERAPY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Identification of human CCR8 as a CCL18 receptor

(2013) Sabina A. Islam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL18 Exhibits a Regulatory Role through Inhibition of Receptor and Glycosaminoglycan Binding

(2013) Sonja C. Krohn et al.   PLoS One

Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response

(2012) Mieke Gouwy et al.   IMMUNOLOGY LETTERS

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1 and leukocyte migration during trauma and sterile inflammation

(2012) Emilie Venereau et al.   MOLECULAR IMMUNOLOGY

CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection

(2011) Mieke Gouwy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells

(2010) Daniel Venetz et al.   INTERNATIONAL JOURNAL OF CANCER

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

(2010) Sandhya Thulasi Das et al.   PLoS One

Chemokine receptor oligomerization: functional considerations

(2009) Marcus Thelen et al.   CURRENT OPINION IN PHARMACOLOGY

Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes

(2009) Katrin Kuscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells

(2009) Lara Campana et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events

(2008) M. Gouwy et al.   MOLECULAR PHARMACOLOGY