Neutrophilic inflammation in asthma: mechanisms and therapeutic considerations

Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment

(2016) Koa Hosoki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

(2016) Jodie L. Simpson et al.   CHEST

Airway dysbiosis:Haemophilus influenzaeandTropherymain poorly controlled asthma

(2015) Jodie L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

(2015) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

(2015) Diana Raedler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma

(2015) Neil C. Thomson et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Christopher E Brightling et al.   Lancet Respiratory Medicine

Occupational exposures, smoking and airway inflammation in refractory asthma

(2015) Jodie L Simpson et al.   BMC Pulmonary Medicine

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma

(2014) M. Kupczyk et al.   ALLERGY

Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils

(2014) Jean-Christophe Simard et al.   FEBS LETTERS

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

(2014) Erika H. De Boever et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

The complex relationship between inflammation and lung function in severe asthma

(2014) M L Manni et al.   Mucosal Immunology

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

Anti-TNF inhibits the Airways neutrophilic inflammation induced by inhaled endotoxin in human

(2014) Olivier Michel et al.   BMC Pharmacology & Toxicology

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma

(2013) Tae-Hyeong Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers

(2013) Michelle L. Hernandez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils in the Spotlight: Eosinophilic airway inflammation in nonallergic asthma

(2013) Guy G Brusselle et al.   NATURE MEDICINE

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1

(2013) Jean-Christophe Simard et al.   PLoS One

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Beyond pattern recognition: NOD-like receptors in dendritic cells

(2013) Jayendra Kumar Krishnaswamy et al.   TRENDS IN IMMUNOLOGY

Statin use and asthma control in patients with severe asthma

(2013) Amir A Zeki et al.   BMJ Open

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response

(2012) E. D. Telenga et al.   ALLERGY

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Asthmatic Airway Neutrophilia after Allergen Challenge Is Associated with the GlutathioneS-Transferase M1 Genotype

(2012) Aimee Hoskins et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Pathogenesis of severe asthma

(2012) A. H. Poon et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Barrier responses of human bronchial epithelial cells to grass pollen exposure

(2012) Cornelia Blume et al.   EUROPEAN RESPIRATORY JOURNAL

Identification of Subtypes of Refractory Asthma in Korean Patients by Cluster Analysis

(2012) An Soo Jang et al.   LUNG

The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway

(2012) Junko Yano et al.   PLoS One

Air trapping is a major determinant of persistent airway obstruction in asthmatics

(2012) Sung-Woo Park et al.   RESPIRATORY MEDICINE

Stability of inflammatory phenotypes in asthma

(2012) Ruth H Green et al.   THORAX

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival

(2011) Arash S. Saffar et al.   CURRENT DRUG TARGETS

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1

(2011) Saskia Braber et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Airway inflammation is augmented by obesity and fatty acids in asthma

(2011) H. A. Scott et al.   EUROPEAN RESPIRATORY JOURNAL

Role of neutrophils in persistent airway obstruction due to refractory asthma

(2011) JAE-SUNG CHOI et al.   RESPIROLOGY

Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells

(2011) Shawn M. Castro et al.   TOXICOLOGY IN VITRO

Inflammasome-IL-1-Th17 response in allergic lung inflammation

(2011) A.-G. Besnard et al.   Journal of Molecular Cell Biology

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

(2010) Kittipong Maneechotesuwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples

(2010) Mohammed T. Al-Samri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone

(2010) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

(2010) Roland Kolbeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

γδ T cells protect against lung fibrosis via IL-22

(2010) Philip L. Simonian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smoking and the outcome of infection

(2010) R. Huttunen et al.   JOURNAL OF INTERNAL MEDICINE

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Sputum IL-6 concentrations in severe asthma and its relationship with FEV1

(2010) J. B. Morjaria et al.   THORAX

Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes

(2010) S. Gupta et al.   THORAX

Linkage between smoking and asthma

(2009) A. Pietinalho et al.   ALLERGY

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor

(2009) E. Mortaz et al.   EUROPEAN RESPIRATORY JOURNAL

ONCOSTATIN M (OSM) IS INCREASED IN ASTHMA WITH INCOMPLETELY REVERSIBLE AIRFLOW OBSTRUCTION

(2009) Jodie L. Simpson et al.   EXPERIMENTAL LUNG RESEARCH

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Neutrophilic asthma has different radiographic features to COPD and smokers

(2009) Jodie L. Simpson et al.   RESPIRATORY MEDICINE

The overlap syndrome of asthma and COPD: what are its features and how important is it?

(2009) P G Gibson et al.   THORAX

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Multivariate Analysis of Risk Factors for the Air-Trapping Asthmatic Phenotype as Measured by Quantitative CT Analysis

(2008) Ashley Busacker et al.   CHEST

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma

(2007) Joanne Shannon et al.   CHEST