Article
Allergy
Ji Wang, Xin Zhang, Li Zhang, Ying Liu, Gang Wang, Hong Ping Zhang, Lei Wang, De Ying Kang, Brian G. Oliver, Hua Jing Wan, Vanessa M. McDonald, Alan Chen-Yu Hsu, Dan Liu, Wei Min Li, Surinder S. Birring, Gang Wang
Summary: This study investigates the clinical characteristics, inflammatory features, phenotypes, and treatment response in elderly asthma patients. The results show that elderly patients have worse airway obstruction, more comorbidities, lower levels of IgE and FeNO, and a higher risk for late-onset and fixed airflow obstruction asthma. Path analysis suggests that age directly contributes to future exacerbations, partially mediated by increased airway IFN-gamma. Furthermore, elderly patients with asthma exhibit a reduced treatment response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Yang Wang, Rongjun Wan, Chengping Hu
Summary: This study found that obesity-related neutrophilic airway inflammation in asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. The research revealed that leptin/obR signaling plays an important role in the pathogenesis of obesity-related neutrophilic airway inflammation.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Anne-Charlotte Jonckheere, Sven F. Seys, Brecht Steelant, Tatjana Decaesteker, Kaat Dekoster, Jonathan Cremer, Ellen Dilissen, Dominique Schols, Yoichiro Iwakura, Greetje Vande Velde, Christine Breynaert, Rik Schrijvers, Jeroen Vanoirbeek, Jan L. Ceuppens, Lieven J. Dupont, Dominique M. A. Bullens
Summary: This study developed a murine model for non-allergic neutrophilic asthma and found that ILC play a key role in inducing airway hyperreactivity. ILC are also associated with inflammatory response and cytokine release.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Mustafa Abdo, Frauke Pedersen, Anne-Marie Kirsten, Vera Veith, Heike Biller, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz
Summary: This study investigated the impact of airway inflammatory phenotypes on small airway dysfunction (SAD) and asthma outcomes. The results showed that patients with eosinophilic and mixed granulocytic asthma had worse lung function, higher exacerbation rates, and poorer symptom control compared to patients with paucigranulocytic asthma. Persistent mixed granulocytic asthma was associated with the worst SAD measures. Changes in sputum eosinophil counts were found to be an independent predictor for the longitudinal change in lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Immunology
Ben A. A. Calvert, Erik J. J. Quiroz, Zareeb Lorenzana, Ngan Doan, Seongjae Kim, Christiana N. N. Senger, Jeffrey J. J. Anders, Wiliam D. D. Wallace, Matthew P. P. Salomon, Jill Henley, Amy L. L. Ryan
Summary: Neutrophils play a crucial role in the innate immune response against viral infection. Chronic airway neutrophilia is associated with severe COVID-19 cases. COVID-19 infection leads to epithelial pathologies and the activation of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Xin-rui Qiao, Tao Feng, Dong Zhang, Li-li Zhi, Jin-tao Zhang, Xiao-fei Liu, Yun Pan, Jia-wei Xu, Wen-Jing Cui, Liang Dong
Summary: This study found that luteolin, a flavonoid substance, can alleviate neutrophilic asthma by inhibiting the IL-36 gamma secretion-mediated MAPK pathway. These findings provide a theoretical basis for the application of luteolin in the treatment of neutrophilic asthma.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fabiana Furci, Giuseppe Murdaca, Corrado Pelaia, Egidio Imbalzano, Girolamo Pelaia, Marco Caminati, Alessandro Allegra, Gianenrico Senna, Sebastiano Gangemi
Summary: The airway epithelium is the first line of defense for the lungs against environmental triggers. It releases alarmin cytokines, which mediate inflammation in chronic lung diseases. This review focuses on the role of pulmonary epithelial cells and airway epithelial cell alarmins in driving inflammation and explores the therapeutic potential of targeting these molecules.
Article
Biochemistry & Molecular Biology
Quang Luu Quoc, Youngwoo Choi, Tra Cao Thi Bich, Eun-Mi Yang, Yoo Seob Shin, Hae-Sim Park
Summary: S100A9 is a potential serum biomarker and therapeutic target for neutrophilic asthma. Patients with neutrophilic asthma had higher levels of S100A9 protein in their blood, which could be used as a potential biomarker and therapeutic target.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Immunology
Jing Zhang, Yuan Zou, Longmin Chen, Qianqian Xu, Yi Wang, Min Xie, Xiansheng Liu, Jianping Zhao, Cong-Yi Wang
Summary: Asthma is a multifactorial disorder characterized by chronic inflammation, hyper-responsiveness, remodeling, and reversible obstruction. Recent studies suggest that most cases are Th2-high type and regulatory T cells (Tregs) play an essential role in limiting the development of allergic diseases. Researchers are exploring new treatment methods based on Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Tajidine Tsiavia, Joseph Henny, Marcel Goldberg, Marie Zins, Nicolas Roche, Laurent Orsi, Rachel Nadif
Summary: This study classified asthma inflammatory phenotypes and found differences in clinical expressions between the phenotypes, which is important for improving asthma management and studying environmental risk factors.
Article
Allergy
Wenzhi Zhan, Feng Wu, Yunhui Zhang, Lin Lin, Wen Li, Wei Luo, Fang Yi, Yuanrong Dai, Suyun Li, Jiangtao Lin, Yadong Yuan, Chen Qiu, Yong Jiang, Limin Zhao, Meihua Chen, Zhongmin Qiu, Ruchong Chen, Jiaxing Xie, Chunxing Guo, Mei Jiang, Xiaohong Yang, Guochao Shi, Dejun Sun, Rongchang Chen, Nanshan Zhong, Huahao Shen, Kefang Lai
Summary: This study classified patients with cough-variant asthma (CVA) into three clusters based on clinical and pathophysiological parameters, and explored the underlying molecular pathways of these phenotypes using transcriptomic data. The findings provide insights into the pathogenesis of CVA and can guide clinicians in developing personalized treatment for cough in asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Chioma Enweasor, Cameron H. Flayer, Angela Haczku
Summary: This review highlights the importance of glucocorticoids in asthma treatment, while also pointing out the negative impact of ozone on asthma and emphasizing the crucial role of oxidative stress pathways in glucocorticoid resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bingqing Shi, Yuqiu Hao, Wei Li, Hongna Dong, Mengting Xu, Peng Gao
Summary: TIPE2 plays different roles in different asthma inflammatory phenotypes and inhibits neutrophilic inflammation by targeting the Nrf2/HO-1 pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Lanlan Li, Yongchang Ma, Yi Hu, Pengfei Wang, Songling Han, Xiangjun Zhang, Jianxiang Zhang
Summary: This article reports a targeted treatment method for asthma using a cyclic oligosaccharide-derived nanotherapy. The treatment effectively alleviates oxidative stress, suppresses inflammatory responses, reverses airway remodelling, and improves pulmonary function. The method shows promising results for the treatment of eosinophilic and neutrophilic asthma.