The complex relationship between inflammation and lung function in severe asthma

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe asthma: from characteristics to phenotypes to endotypes

(2012) S. Wenzel   CLINICAL AND EXPERIMENTAL ALLERGY

Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines

(2012) Cara J. Bossley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

TH17 cells in asthma and inflammation

(2011) Shean J. Aujla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation

(2011) Jennifer Louten et al.   INTERNATIONAL IMMUNOLOGY

TH17 Cells in Asthma and COPD

(2010) John F. Alcorn et al.   Annual Review of Physiology

IL-17 and IL-22 in atopic allergic disease

(2010) Yuri Souwer et al.   CURRENT OPINION IN IMMUNOLOGY

Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial

(2010) S. T. Holgate et al.   EUROPEAN RESPIRATORY JOURNAL

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

(2010) Annette T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

(2010) Jean Bousquet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

(2010) Stephane Lajoie et al.   NATURE IMMUNOLOGY

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Allergic Sensitization through the Airway Primes Th17-dependent Neutrophilia and Airway Hyperresponsiveness

(2009) Rhonda H. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2–IL-33 Pathway

(2009) Jennifer Kearley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Etiopathogenesis of Behcet's disease

(2009) Claudia Mendoza-Pinto et al.   AUTOIMMUNITY REVIEWS

Mucus hypersecretion in asthma: causes and effects

(2008) Christopher M Evans et al.   CURRENT OPINION IN PULMONARY MEDICINE

The role of a soluble TNF  receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial

(2008) J B Morjaria et al.   THORAX

Targeting TNF-α: A novel therapeutic approach for asthma

(2007) Christopher Brightling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY