Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system

Controlled release strategies for rAAV-mediated gene delivery

(2016) Ana Rey-Rico et al.   Acta Biomaterialia

TGF-β gene transfer and overexpressionviarAAV vectors stimulates chondrogenic events in human bone marrow aspirates

(2016) Janina Frisch et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Preclinical safety evaluation of recombinant adeno-associated virus 2 vector encoding human tumor necrosis factor receptor-immunoglobulin Fc fusion gene

(2016) Xiaobing Zhou et al.   Human Vaccines & Immunotherapeutics

PEO–PPO–PEO micelles as effective rAAV-mediated gene delivery systems to target human mesenchymal stem cells without altering their differentiation potency

(2015) Ana Rey-Rico et al.   Acta Biomaterialia

Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency

(2015) Ana Rey-Rico et al.   Acta Biomaterialia

Biologics for tendon repair

(2015) Denitsa Docheva et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends

(2015) Taimoor H. Qazi et al.   BIOMATERIALS

rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

(2015) J Frisch et al.   GENE THERAPY

Adeno-associated virus-2-mediated TGF-β1 microRNA transfection inhibits adhesion formation after digital flexor tendon injury

(2015) Y F Wu et al.   GENE THERAPY

Effective genetic modification and differentiation of hMSCs upon controlled release of rAAV vectors using alginate/poloxamer composite systems

(2015) P. Díaz-Rodríguez et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Implantation of rAAV5-IGF-I Transduced Autologous Chondrocytes Improves Cartilage Repair in Full-thickness Defects in the Equine Model

(2015) Kyla F Ortved et al.   MOLECULAR THERAPY

Gene therapy approaches to regenerating the musculoskeletal system

(2015) Christopher H. Evans et al.   Nature Reviews Rheumatology

Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I

(2015) Janina Frisch et al.   TISSUE ENGINEERING PART A

Safety, Biodistribution, and Efficacy of an AAV-5 Vector Encoding Human Interferon-Beta (ART-I02) Delivered via Intra-Articular Injection in Rhesus Monkeys with Collagen-Induced Arthritis

(2015) Lisette Bevaart et al.   Human Gene Therapy Clinical Development

The potential of adeno-associated viral vectors for gene delivery to muscle tissue

(2014) Dan Wang et al.   Expert Opinion on Drug Delivery

Determination of effective rAAV-mediated gene transfer conditions to support chondrogenic differentiation processes in human primary bone marrow aspirates

(2014) A Rey-Rico et al.   GENE THERAPY

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Determination of the Chondrogenic Differentiation Processes in Human Bone Marrow-Derived Mesenchymal Stem Cells Genetically Modified to Overexpress Transforming Growth Factor-β via Recombinant Adeno-Associated Viral Vectors

(2014) Janina Frisch et al.   HUMAN GENE THERAPY

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions

(2014) Sys Hasslund et al.   Journal of Tissue Engineering

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

(2013) Jagadeesh K Venkatesan et al.   Journal of Translational Medicine

Advances in Regenerative Orthopedics

(2013) Christopher H. Evans   MAYO CLINIC PROCEEDINGS

Multiple Recombinant Adeno-Associated Viral Vector Serotypes Display Persistent In Vivo Gene Expression in Vector-Transduced Rat Stifle Joints

(2013) Jeffrey B. Mason et al.   Human Gene Therapy Methods

Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

(2013) Laurie R Goodrich et al.   Molecular Therapy-Nucleic Acids

Humoral Immune Response to AAV

(2013) Roberto Calcedo et al.   Frontiers in Immunology

The gene therapy journey for hemophilia: are we there yet?

(2012) K. A. High   BLOOD

Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis

(2012) W. Zhang et al.   INTERNATIONAL IMMUNOLOGY

A primer in cartilage repair

(2012) T. Minas   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Virus-mediated gene delivery for human gene therapy

(2012) Mauro Giacca et al.   JOURNAL OF CONTROLLED RELEASE

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

(2012) Magali Cucchiarini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cell- and gene-based approaches to tendon regeneration

(2012) Alan J. Nixon et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

Adeno-associated virus-coated allografts: a novel approach for cranioplasty

(2012) Ayelet Ben Arav et al.   Journal of Tissue Engineering and Regenerative Medicine

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice

(2011) Quan Zhou et al.   ARTHRITIS AND RHEUMATISM

Epirubicin potentiates recombinant adeno-associated virus type 2/5-mediated TRAIL expression in fibroblast-like synoviocytes and augments the antiarthritic effects of rAAV2/5-TRAIL

(2011) Juan Shi et al.   ARTHRITIS AND RHEUMATISM

Synthetic scaffold coating with adeno-associated virus encoding BMP2 to promote endogenous bone repair

(2011) Kenneth M. Dupont et al.   CELL AND TISSUE RESEARCH

PEO-PPO Block Copolymers for Passive Micellar Targeting and Overcoming Multidrug Resistance in Cancer Therapy

(2011) C. Alvarez-Lorenzo et al.   CURRENT DRUG TARGETS

Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur

(2011) Cemal Yazici et al.   MOLECULAR THERAPY

Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees

(2011) K.A. Payne et al.   OSTEOARTHRITIS AND CARTILAGE

Release of Bioactive Adeno-Associated Virus from Fibrin Scaffolds: Effects of Fibrin Glue Concentrations

(2011) Hannah H. Lee et al.   TISSUE ENGINEERING PART A

Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis

(2010) Maroun Khoury et al.   ARTHRITIS AND RHEUMATISM

Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study

(2010) Erhan Basad et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors

(2010) Gilles Moulay et al.   PLoS One

Nonviral Gene Delivery: Principle, Limitations, and Recent Progress

(2009) Mohammed S. Al-Dosari et al.   AAPS Journal

The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure

(2009) Tao Zhang et al.   BIOMATERIALS

Molecular targets for tendon neoformation

(2009) Hadi Aslan et al.   JOURNAL OF CLINICAL INVESTIGATION

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

(2009) Roberto Calcedo et al.   JOURNAL OF INFECTIOUS DISEASES

Biological activation of bone-related biomaterials by recombinant adeno-associated virus vector

(2009) Tomonori Nasu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cell-based resurfacing of large cartilage defects: Long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis

(2008) Kolja Gelse et al.   ARTHRITIS AND RHEUMATISM

The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings

(2008) Cemal Yazici et al.   BIOMATERIALS

Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX

(2008) J. Sun et al.   BLOOD

Gene Therapy Using Adeno-Associated Virus Vectors

(2008) S. Daya et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure-function relationships in tendons: a review

(2008) M. Benjamin et al.   JOURNAL OF ANATOMY

Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery

(2008) Patrick Basile et al.   MOLECULAR THERAPY

Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1α activity

(2008) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE