Gene therapy approaches to regenerating the musculoskeletal system

Regenerative Medicine for the Musculoskeletal System Based on Muscle-derived Stem Cells

(2016) Charley B. Gates et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2

(2014) Clark J. Needham et al.   Acta Biomaterialia

Tissue-engineered cartilage with inducible and tunable immunomodulatory properties

(2014) Katherine A. Glass et al.   BIOMATERIALS

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

(2014) M Cucchiarini et al.   GENE THERAPY

Nonviral gene transfer to human meniscal cells. Part I: transfection analyses and cell transplantation to meniscus explants

(2014) Hsiao-Ping Lee et al.   INTERNATIONAL ORTHOPAEDICS

Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues

(2014) Christopher Evans   INTERNATIONAL ORTHOPAEDICS

Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage

(2014) Jonathan M. Brunger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The promotion of bone regeneration through positive regulation of angiogenic–osteogenic coupling using microRNA-26a

(2013) Yan Li et al.   BIOMATERIALS

Non-viral gene therapy for bone tissue engineering

(2013) Fiona Wegman et al.   Biotechnology & Genetic Engineering Reviews

Repair of bone defect by using vascular bundle implantation combined with Runx II gene-transfected adipose-derived stem cells and a biodegradable matrix

(2013) Dong Han et al.   CELL AND TISSUE RESEARCH

Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair

(2013) F Alaee et al.   GENE THERAPY

Use of an Antifibrotic Agent Improves the Effect of Platelet-Rich Plasma on Muscle Healing After Injury

(2013) Satoshi Terada et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres

(2013) Corinne Sonnet et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Advances in Regenerative Orthopedics

(2013) Christopher H. Evans   MAYO CLINIC PROCEEDINGS

Engineering of a functional bone organ through endochondral ossification

(2013) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arthritis gene therapy and its tortuous path into the clinic

(2013) Christopher H. Evans et al.   Translational Research

Humoral Immune Response to AAV

(2013) Roberto Calcedo et al.   Frontiers in Immunology

Delivery of Growth Factors for Tissue Regeneration and Wound Healing

(2012) Piyush Koria   BIODRUGS

Biological approaches to improve skeletal muscle healing after injury and disease

(2012) Burhan Gharaibeh et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Scaffold: A Novel Carrier for Cell and Drug Delivery

(2012) Tarun Garg et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients

(2012) Chul-Won Ha et al.   CYTOTHERAPY

scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints

(2012) R S Watson et al.   GENE THERAPY

The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury

(2012) Tetsuo Kobayashi et al.   JOURNAL OF APPLIED PHYSIOLOGY

A primer in cartilage repair

(2012) T. Minas   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

(2012) Magali Cucchiarini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Enhanced Adenovirus Transduction of hMSCs Using 3D Hydrogel Cell Carriers

(2012) Alexander J. Neumann et al.   MOLECULAR BIOTECHNOLOGY

Bone Marrow–Derived Mesenchymal Stem Cells Transduced With Scleraxis Improve Rotator Cuff Healing in a Rat Model

(2011) Lawrence V. Gulotta et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display

(2011) Yanbin Pi et al.   BIOMATERIALS

Synthetic scaffold coating with adeno-associated virus encoding BMP2 to promote endogenous bone repair

(2011) Kenneth M. Dupont et al.   CELL AND TISSUE RESEARCH

Gene therapy for the regeneration of bone

(2011) Christopher Evans   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Orthopedic gene therapy-lost in translation?

(2011) C.H. Evans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds

(2011) Erica G. Tierney et al.   JOURNAL OF CONTROLLED RELEASE

Lentiviral-based BMP4 in vivo gene transfer strategy increases pull-out tensile strength without an improvement in the osteointegration of the tendon graft in a rat model of biceps tenodesis

(2011) Michael J. Coen et al.   JOURNAL OF GENE MEDICINE

Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo

(2011) Patrick Orth et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur

(2011) Cemal Yazici et al.   MOLECULAR THERAPY

“Same Day” Ex-vivo Regional Gene Therapy: A Novel Strategy to Enhance Bone Repair

(2011) Mandeep S Virk et al.   MOLECULAR THERAPY

Gene Therapy for Intervertebral Disk Degeneration

(2011) Barrett I. Woods et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Direct delayed human adenoviral BMP-2 or BMP-6 gene therapy for bone and cartilage regeneration in a pony osteochondral model

(2011) M.I. Menendez et al.   OSTEOARTHRITIS AND CARTILAGE

Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis

(2011) Paolo Alberton et al.   STEM CELLS AND DEVELOPMENT

Adenoviral-Mediated Gene Transfer of Human Bone Morphogenetic Protein–13 Does Not Improve Rotator Cuff Healing in a Rat Model

(2010) Lawrence V. Gulotta et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells

(2010) Meike Haddad-Weber et al.   CYTOTHERAPY

Articular cartilage repair by genetically modified bone marrow aspirate in sheep

(2010) A Ivkovic et al.   GENE THERAPY

Getting arthritis gene therapy into the clinic

(2010) Christopher H. Evans et al.   Nature Reviews Rheumatology

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

(2009) N. Wehling et al.   ARTHRITIS AND RHEUMATISM

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble flt-1

(2009) Tomoyuki Matsumoto et al.   ARTHRITIS AND RHEUMATISM

Enhanced Meniscal Repair by Overexpression of hIGF-1 in a Full-thickness Model

(2009) Haining Zhang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats

(2009) T Xue et al.   GENE THERAPY

rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival and α-SMA expression in human meniscal lesions

(2009) M Cucchiarini et al.   GENE THERAPY

Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons

(2009) Lauren V. Schnabel et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effects of transforming growth factor-β1 and vascular endothelial growth factor 165 gene transfer on Achilles tendon healing

(2009) Yu Hou et al.   MATRIX BIOLOGY

Enhancement of Myogenic and Muscle Repair Capacities of Human Adipose–derived Stem Cells With Forced Expression of MyoD

(2009) Sébastien Goudenege et al.   MOLECULAR THERAPY

Effect of VEGF on the Regenerative Capacity of Muscle Stem Cells in Dystrophic Skeletal Muscle

(2009) Bridget M Deasy et al.   MOLECULAR THERAPY

SEIZURE CHARACTERISTICS AND CONTROL AFTER MICROSURGICAL RESECTION OF SUPRATENTORIAL CEREBRAL CAVERNOUS MALFORMATIONS

(2009) Edward F. Chang et al.   NEUROSURGERY

Improved Muscle Healing after Contusion Injury by the Inhibitory Effect of Suramin on Myostatin, a Negative Regulator of Muscle Growth

(2008) Masahiro Nozaki et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Angiotensin II Receptor Blockade Administered after Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal Muscle

(2008) Hany S. Bedair et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Application of inflammation‐responsive promoter for an in vitro arthritis model

(2008) P. Sivaramakrishna Rachakonda et al.   ARTHRITIS AND RHEUMATISM

Cell-based resurfacing of large cartilage defects: Long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis

(2008) Kolja Gelse et al.   ARTHRITIS AND RHEUMATISM

Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model

(2008) Mandeep Singh Virk et al.   BONE

Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?

(2008) Pernilla Eliasson et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model

(2008) M Majewski et al.   GENE THERAPY

Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models

(2008) W Lattanzi et al.   GENE THERAPY

Adeno-Associated Virus-2-Mediated bFGF Gene Transfer to Digital Flexor Tendons Significantly Increases Healing Strength

(2008) Jin Bo Tang et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Effect of Interleukin-10 Overexpression on the Properties of Healing Tendon in a Murine Patellar Tendon Model

(2008) Eric T. Ricchetti et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Effect of cell-based VEGF gene therapy on healing of a segmental bone defect

(2008) Ru Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery

(2008) Patrick Basile et al.   MOLECULAR THERAPY

Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat

(2007) Charles H. Rundle et al.   JOURNAL OF GENE MEDICINE