Review
Pharmacology & Pharmacy
Yi Yu, Tingting Yu, Xing Wang, Dawei Liu
Summary: Craniomaxillofacial bone defects are challenging to treat due to their complex nature and specific requirements. Conventional clinical treatments are insufficient for high-quality bone regeneration. Hydrogels, with their unique properties, offer promising solutions for craniomaxillofacial bone regeneration. This review discusses the potential of hydrogel systems and summarizes recent developments in this field. Furthermore, it explores the prospects of craniomaxillofacial bone tissue engineering and provides inspiration for future hydrogel designs.
Review
Cell & Tissue Engineering
Behnaz Banimohamad-Shotorbani, Sonia Fathi Karkan, Reza Rahbarghazi, Ahmad Mehdipour, Seyedhosein Jarolmasjed, Sepideh Saghati, Hajar Shafaei
Summary: Bone defects are common damages in human medicine, and recent advancements in cell sheet technology have offered a promising approach for osteogenesis in craniomaxillofacial (CMF) bone regeneration. The intact matrix secreted from cells provides a unique microenvironment for accelerating osteoangiogenesis. Both single-layer and multilayer cell sheets have been investigated in preclinical settings for CMF engineering, showing potential for effective bone recovery.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Nanoscience & Nanotechnology
Haizhu Kuang, Jing Ma, Xinyu Chi, Qichen Fu, Qianzhe Zhu, Weiling Cao, Peng Zhang, Xin Xie
Summary: The researchers reported a new therapeutic tool called Exo@miR-26a that can target multiple genes by inducing translation repression and target mRNA degradation. Exo@miR-26a significantly promotes bone regeneration and further facilitates healthy bone regeneration by repressing osteoclast differentiation-related genes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Linqi Guo, Zhihui Liang, Liang Yang, Wenyan Du, Tao Yu, Huayu Tang, Changde Li, Hongbin Qiu
Summary: Bone is a dynamic self-healing organ with continuous remodeling, but surgical interventions and bone substitutes are needed for repairing large traumatic injuries. Bone tissue engineering aims to repair and regenerate tissues, with natural polymers like collagen and chitosan widely used in the field.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Wenpeng Song, Xiaowen Bo, Xiaohan Ma, Kegui Hou, Dan Li, Wei Geng, Jianyu Zeng
Summary: Craniomaxillofacial bone defects have a significant impact on patients' appearance, function, and psychological well-being. Bone marrow mesenchymal stem cells (BMSCs) are being explored as an alternative for the repair and reconstruction of these defects. This article compares the characteristics of craniomaxillofacial BMSCs (C-BMSCs) with other sources of BMSCs in terms of osteogenesis, angiogenesis, and immune regulation, and proposes ideas such as 3D printing and mechanotherapy to harness the potential of C-BMSCs.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Cell & Tissue Engineering
Alexander Stahl, Yunzhi Peter Yang
Summary: Engineered materials are increasingly used as substitutes for autologous bone grafts in orthopedic practice, but their regenerative efficacy is still limited. Large bone defects greater than 4-5 cm require more complex surgical interventions for repair. Current focus is on improving tissue engineering and vascularization strategies for large bone defect repair.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Article
Engineering, Biomedical
Daniela Medrano-David, Aura Maria Lopera, Martha Elena Londono, Pedronel Araque-Marin
Summary: The study developed an injectable bone substitute (IBS) with great potential for bone tissue regeneration, by incorporating DBM into a PVA/glycerol network cross-linked with borax and reinforced with CaCO3. The material showed good bioactivity and physicochemical properties suitable for bone tissue regeneration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zhuyun Cai, Heng Jiang, Tao Lin, Ce Wang, Jun Ma, Rui Gao, Yingying Jiang, Xuhui Zhou
Summary: Microspheres and microsphere-based scaffolds have shown great potential in translational medicine. This review summarizes the various fabrication methods for microspheres, discusses the limitations of existing techniques, and describes the appropriate materials and surface-modification strategies to enhance the biological properties of microspheres. The key application of microsphere-functionalized scaffolds for bone tissue engineering is also discussed.
MATERIALS TODAY ADVANCES
(2022)
Article
Engineering, Biomedical
Zhuo Li, Haixing Wang, Kunyu Zhang, Boguang Yang, Xian Xie, Zhengmeng Yang, Lingchi Kong, Peng Shi, Yuan Zhang, Yi-Ping Ho, Zhi-Yong Zhang, Gang Li, Liming Bian
Summary: The research assembled a biomimetic hyaluronic acid nanocomposite hydrogel with bisphosphonates (BPs), and demonstrated its expedited release of BPs in an acidic environment. The in vitro studies showed that the hydrogel inhibits mature osteoclastic differentiation, while promoting the initial differentiation of primary macrophages to preosteoclasts. In vivo evaluation confirmed the hydrogel's ability to enhance in situ bone regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Review
Engineering, Biomedical
Guanyin Zhu, Tianxu Zhang, Miao Chen, Ke Yao, Xinqi Huang, Bo Zhang, Yazhen Li, Jun Liu, Yunbing Wang, Zhihe Zhao
Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Milena S. Malherbi, Luciano C. Dias, Mariana S. Z. Lima, Larissa G. Ribeiro, Valdirlei F. Freitas, Taiana G. M. Bonadio, Ludmilla M. Silva, Gilvan B. Souza, Eduardo A. Volnistem, Jaciele M. Rosso, Daniel M. Silva, Luiz F. Cotica, Wilson R. Weinand, Ivair A. Santos
Summary: This study synthesized hydroxyapatite/beta-tricalcium phosphate/polyvinylidene fluoride biocomposites and used electrical stimuli to improve and accelerate bone regeneration in vitro. The results showed that the growth rate of hydroxyapatite in the biocomposite significantly increased under specific electric field conditions.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Review
Engineering, Biomedical
Elia Bosch-Rue, Leire Diez-Tercero, Jenifer Olmos Buitrago, Emilio Castro, Roman A. Perez
Summary: Bone has the ability to self-regenerate, but extensive damage can hinder the natural regeneration process. Bone tissue engineering aims to mimic the extracellular matrix and promote the physiological regeneration process by stimulating osteogenesis and angiogenesis.
ACTA BIOMATERIALIA
(2023)
Review
Biotechnology & Applied Microbiology
V. K. Anupama Devi, Anjaneyulu Udduttula, Amit Kumar Jaiswal
Summary: Biomedical uses for natural polysaccharides of marine origin, including fucoidan derived from brown algae, are gaining popularity. Despite being less researched compared to other biomaterials, fucoidan is more accessible and cost-effective. This review provides an overview of its history, sources, and characteristics, with a focus on its application in bone tissue engineering. The global research status of fucoidan, especially for bone tissue engineering, is examined, making this study a comprehensive manual for understanding its research status.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Materials Science, Biomaterials
Blaire V. Slavin, Quinn T. Ehlen, Joseph P. Costello, Vasudev Vivekanand Nayak, Estavam A. Bonfante, Ernesto B. Benalcazar Jalkh, Christopher M. Runyan, Lukasz Witek, Paulo G. Coelho
Summary: The field of cranio-maxillofacial (CMF) surgery is complex, and computer-aided design (CAD) and additive manufacturing (AM) offer opportunities for repairing CMF defects through 3D printed scaffolds and fixation devices. In vitro and in vivo studies are ongoing to optimize the design and composition of these scaffolds to promote bone regeneration. 3D printed anatomical models and surgical guides also have benefits for preoperative and intraoperative use. Extensive research, manufacturing capabilities, and regulatory oversight are required for the creation and implementation of these devices.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Dmitriy Sheyn, Doron Cohn-Yakubovich, Shiran Ben-David, Sandra De Mel, Virginia Chan, Christopher Hinojosa, Norman Wen, Geraldine A. Hamilton, Dan Gazit, Zulma Gazit
MICROFLUIDICS AND NANOFLUIDICS
(2019)
Article
Materials Science, Multidisciplinary
Aneel Bherwani, Chung-Chueh Chang, Gadi Pelled, Zulma Gazit, Dan Gazit, Miriam Rafailovich, Marcia Simon
Review
Endocrinology & Metabolism
Maxim Bez, Gadi Pelled, Dan Gazit
Article
Multidisciplinary Sciences
Tali Ilovitsh, Yi Feng, Josquin Foiret, Azadeh Kheirolomoom, Hua Zhang, Elizabeth S. Ingham, Asaf Ilovitsh, Spencer K. Tumbale, Brett Z. Fite, Bo Wu, Marina N. Raie, Nisi Zhang, Aris J. Kare, Michael Chavez, Lei S. Qi, Gadi Pelled, Dan Gazit, Ophir Vermesh, Idan Steinberg, Sanjiv S. Gambhir, Katherine W. Ferrara
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cell & Tissue Engineering
Gadi Pelled, Raphael Lieber, Pablo Avalos, Doron Cohn-Schwartz, Wafa Tawackoli, Joseph Roth, Emma Knapp, Edward M. Schwarz, Hani A. Awad, Dan Gazit, Zulma Gazit
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Review
Cell Biology
Zoe Krut, Gadi Pelled, Dan Gazit, Zulma Gazit
Summary: Intervertebral disc degeneration (IVDD) is a result of imbalanced anabolic and catabolic processes in the disc, naturally occurring with age. Current treatments lack the ability to stop disease progression or restore functionality, while stem cell-derived exosomes show potential as a therapeutic option.
Article
Multidisciplinary Sciences
Gadi Pelled, Margaux M. Salas, Pei Han, Howard E. Gill, Karl A. Lautenschlager, Tristan T. Lai, Cameron M. Shawver, Matthew B. Hoch, Brandon J. Goff, Aaron M. Betts, Zhengwei Zhou, Cody Lynch, Grant Schroeder, Maxim Bez, Marcel M. Maya, Catherine Bresee, Zulma Gazit, John P. McCallin, Dan Gazit, Debiao Li
Summary: The study suggests that qCEST MRI can be used as an effective diagnostic tool for identifying the specific source of chronic low back pain, with higher sensitivity and specificity compared to PD. The qCEST signal values and qCEST/T2w ratio were found to be significantly different between painful and non-painful discs, indicating its potential for improved diagnosis of discogenic pain.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Zoe Krut, Dan Gazit, Zulma Gazit, Gadi Pelled
Summary: Research on non-viral gene delivery systems for tissue regeneration is ongoing, with a focus on optimizing gene transfer efficiency. Sonoporation, a technique that uses ultrasound to induce transient membrane permeabilization, has shown significant potential for increasing tissue regeneration. While clinical trials specifically for tissue regeneration have not been conducted yet, current trials for other indications suggest that sonoporation is safe for clinical use.
BIOENGINEERING-BASEL
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Xiran Cai, Josquin Foiret, Joseph Roth, Zulma Gazit, Gadi Pelled, Dan Gazit, Katherine W. Ferrara
2019 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
(2019)
