The role of naloxegol in the management of opioid-induced bowel dysfunction

Methylnaltrexone for opioid-induced constipation: review and meta-analyses for objective plus subjective efficacy and safety outcomes

(2016) Waldemar Siemens et al.   Therapeutics and Clinical Risk Management

Opioid-induced constipation: advances and clinical guidance

(2016) Alfred D. Nelson et al.   Therapeutic Advances in Chronic Disease

A Randomized, Placebo-Controlled Trial of Lubiprostone for Opioid-Induced Constipation in Chronic Noncancer Pain

(2015) M Mazen Jamal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients

(2015) Nidal Al-Huniti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Naloxegol: A Review of Its Use in Patients with Opioid-Induced Constipation

(2015) Karly P. Garnock-Jones   DRUGS

Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects

(2015) Khanh Bui et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Definitions and Outcome Measures of Clinical Trials Regarding Opioid-induced Constipation

(2015) Jan Gaertner et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The effect of quinidine, a strong P-glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol

(2015) Khanh Bui et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation

(2015) Charles E. Argoff et al.   PAIN MEDICINE

Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction

(2015) Wojciech Leppert   Drug Design Development and Therapy

Evolving paradigms in the treatment of opioid-induced bowel dysfunction

(2015) Jakob Lykke Poulsen et al.   Therapeutic Advances in Gastroenterology

Efficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate response

(2015) Jan Tack et al.   United European Gastroenterology Journal

Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation

(2015) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Randomised clinical trial: the long-term safety and tolerability of naloxegol in patients with pain and opioid-induced constipation

(2014) L. Webster et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The effects of mild or moderate hepatic impairment on the pharmacokinetics, safety, and tolerability of naloxegol

(2014) Khanh Bui et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The effects of renal impairment on the pharmacokinetics, safety, and tolerability of naloxegol

(2014) Khanh Bui et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain

(2014) William D. Chey et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Study of Lubiprostone for Opioid-Induced Constipation in Patients with Chronic Noncancer Pain

(2014) Byron Cryer et al.   PAIN MEDICINE

Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain

(2014) Sam H. Ahmedzai et al.   SUPPORTIVE CARE IN CANCER

Efficacy of Pharmacological Therapies for the Treatment of Opioid-Induced Constipation: Systematic Review and Meta-Analysis

(2013) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Evaluation of the Effect of Naloxegol on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled Crossover Thorough QT/QTc Study in Healthy Volunteers

(2013) Christer Gottfridsson et al.   CLINICAL THERAPEUTICS

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

(2013) Lynn Webster et al.   PAIN

Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− Currents

(2012) John Cuppoletti et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Opioid-Induced Bowel Dysfunction

(2012) Christina Brock et al.   DRUGS

Validated tools for evaluating opioid-induced bowel dysfunction

(2011) Anne Estrup Olesen et al.   ADVANCES IN THERAPY

Gastrointestinal side effects in chronic opioid users: results from a population-based survey

(2010) S. F. COOK et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Methylnaltrexone and Gastrointestinal Perforation

(2010) Ann Corken Mackey et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

(210) Results from a phase I, double-blind, randomized, placebo-controlled, multiple-dose study evaluating the safety, tolerability, and pharmacokinetics of oral doses of NKTR-118

(2008) D. Sahner et al.   JOURNAL OF PAIN

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE

Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach

(2008) Karen Reimer et al.   PHARMACOLOGY