Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans

A study of the role of Notch1 and JAG1 gene methylation in development of breast cancer

(2016) Huapeng Sun et al.   MEDICAL ONCOLOGY

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

(2016) Junjie Hu et al.   Scientific Reports

Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

(2015) Nasser Ghaly Yousif et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Future directions in the treatment of cholangiocarcinoma

(2015) Andrew X. Zhu   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Systemic therapy of cholangiocarcinoma: From chemotherapy to targeted therapies

(2015) N. Schweitzer et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Role of surgery in cholangiocarcinoma: From resection to transplantation

(2015) Ulf P. Neumann et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Epidemiology of cholangiocarcinoma

(2015) Annika Bergquist et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

The complex role of NOTCH receptors and their ligands in the development of hepatoblastoma, cholangiocarcinoma and hepatocellular carcinoma

(2015) Borja Gil-García et al.   BIOLOGY OF THE CELL

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Differential effects of targeting Notch receptors in a mouse model of liver cancer

(2015) Erik G. Huntzicker et al.   HEPATOLOGY

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Pathogenesis of Cholangiocarcinoma

(2014) Sumera Rizvi et al.   DIGESTIVE DISEASES

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

Emerging roles of Notch signaling in liver disease

(2014) Fabian Geisler et al.   HEPATOLOGY

Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation

(2014) Naoki Terada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genomic and transcriptional alterations of cholangiocarcinoma

(2014) Takeshi Ito et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas

(2013) Steffen Zender et al.   CANCER CELL

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells

(2013) Shinzo Yamamoto et al.   CARCINOGENESIS

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

On the role of notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development

(2013) Matthias Evert et al.   HEPATOLOGY

Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting

(2013) Alphonse E. Sirica et al.   HEPATOLOGY

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo

(2013) Mona El Khatib et al.   PLoS One

Notch signalling beyond liver development: Emerging concepts in liver repair and oncogenesis

(2013) Carola Maria Morell et al.   Clinics and Research in Hepatology and Gastroenterology

Constitutive Notch2 signaling induces hepatic tumors in mice

(2012) Michael T. Dill et al.   HEPATOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling in human development and disease

(2012) Andrea L. Penton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular mechanisms of liver and bile duct development

(2012) Yiwei Zong et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Expression and Clinicopathological Significance of Notch Signaling and Cell-Fate Genes in Biliary Tract Cancer

(2011) Pawel K Mazur et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Alagille syndrome: pathogenesis, diagnosis and management

(2011) Peter D Turnpenny et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Risk factors for cholangiocarcinoma

(2011) Gia L. Tyson et al.   HEPATOLOGY

Cholangiocarcinoma—controversies and challenges

(2011) Tushar Patel   Nature Reviews Gastroenterology & Hepatology

The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E. Sirica   Nature Reviews Gastroenterology & Hepatology

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Biliary differentiation and bile duct morphogenesis in development and disease

(2009) Peggy Raynaud et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY