Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

(2013) Massimiliano Cadamuro et al.   HEPATOLOGY

Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor

(2013) Audrey Clapéron et al.   HEPATOLOGY

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

(2013) Raghu Kadaba et al.   JOURNAL OF PATHOLOGY

Transforming Growth Factor β Neutralization Ameliorates Pre-Existing Hepatic Fibrosis and Reduces Cholangiocarcinoma in Thioacetamide-Treated Rats

(2013) Hong Ling et al.   PLoS One

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

(2012) I. S. Chan et al.   CANCER RESEARCH

De Novo Design of a Tumor-Penetrating Peptide

(2012) L. Alberici et al.   CANCER RESEARCH

Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma

(2012) J. C. Mertens et al.   CANCER RESEARCH

Inhibition of hedgehog signaling attenuates carcinogenesisin vitroand increases necrosis of cholangiocellular carcinoma

(2012) Mona El Khatib et al.   HEPATOLOGY

Novel organotypic culture model of cholangiocarcinoma progression

(2012) Deanna J. W. Campbell et al.   HEPATOLOGY RESEARCH

Activated hepatic stellate cells mediate the differentiation of macrophages

(2012) Jonathan Chang et al.   HEPATOLOGY RESEARCH

Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling

(2012) Akshay Pratap et al.   JOURNAL OF DRUG TARGETING

Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate

(2012) Youngchul Kim et al.   LIVER INTERNATIONAL

Desmoplasia: A Response or a Niche?

(2012) Yves A. DeClerck   Cancer Discovery

Hedgehog signaling in cholangiocytes

(2011) Alessia Omenetti et al.   CURRENT OPINION IN GASTROENTEROLOGY

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

(2011) Christian D. Fingas et al.   HEPATOLOGY

The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E. Sirica   Nature Reviews Gastroenterology & Hepatology

Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma

(2011) Fujimoto   ONCOLOGY REPORTS

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

Circulating CD14+CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma

(2010) C. Subimerb et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts

(2010) K. Walter et al.   CLINICAL CANCER RESEARCH

Molecular Targeted Therapy of Biliary Tract Cancer – Results of the First Clinical Studies

(2010) Marcus W. Wiedmann et al.   CURRENT DRUG TARGETS

Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment

(2010) Somchai Pinlaor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas

(2010) Catherine I. Dumur et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis

(2010) Suksanti Prakobwong et al.   INTERNATIONAL JOURNAL OF CANCER

Stromal Depletion Goes on Trial in Pancreatic Cancer

(2010) K. Garber   JNCI-Journal of the National Cancer Institute

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

(2010) Kusumawadee Utispan et al.   Molecular Cancer

Hepatic Stellate Cells May Relate to Progression of Intrahepatic Cholangiocarcinoma

(2009) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma

(2009) Yunosuke Nishihara et al.   HISTOPATHOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma

(2008) Shinichi Aishima et al.   MODERN PATHOLOGY