Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Comparative Efficacies of Long-Term Serial Transplantation of Syngeneic, Allogeneic, Xenogeneic, or CTLA4Ig-Overproducing Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Murine Systemic Lupus Erythematosus

(2016) Eun Wha Choi et al.   CELL TRANSPLANTATION

Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)

(2015) Xin He et al.   CELL AND TISSUE RESEARCH

Wnt/β-catenin signaling in bone marrow niche

(2015) Ahmad Ahmadzadeh et al.   CELL AND TISSUE RESEARCH

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

(2015) Dandan Wang et al.   Cellular & Molecular Immunology

Targeting microRNAs for immunomodulation

(2015) Lukas T Jeker et al.   CURRENT OPINION IN PHARMACOLOGY

miR-29a modulates tumor necrosis factor-α-induced osteogenic inhibition by targeting Wnt antagonists

(2015) Caixia Li et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

MicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/GSK-3β/β-catenin pathway

(2015) Jiling Sun et al.   Diagnostic Pathology

Noncoding RNAs, cytokines, and inflammation-related diseases

(2015) José Luiz Marques-Rocha et al.   FASEB JOURNAL

Blockage of Wnt/β-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro

(2015) Marilia Campos Tavares Novo et al.   IMMUNOBIOLOGY

MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression

(2015) Cheng-gui Miao et al.   IMMUNOLOGY LETTERS

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

(2015) Cheng-gui Miao et al.   IMMUNOLOGY LETTERS

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2

(2015) Cheng-gui Miao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)

(2015) YU-FENG XIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal

(2015) Belma Melda Abidin et al.   JOURNAL OF IMMUNOLOGY

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

(2015) Amol Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

The microRNA regulatory network: a far-reaching approach to the regulate the Wnt signaling pathway in number of diseases

(2015) Shahid Mahmood et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies

(2015) Ke Yang et al.   LABORATORY INVESTIGATION

Metadherin contributes to the pathogenesis of chronic lymphocytic leukemia partially through Wnt/β-catenin pathway

(2015) Pei-Pei Li et al.   MEDICAL ONCOLOGY

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

Disarming Wnt

(2015) Roel Nusse   NATURE

Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4

(2015) Eleni Krasoudaki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting the WNT Signaling Pathway in Cancer Therapeutics

(2015) D. Tai et al.   ONCOLOGIST

Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease

(2015) Emilio G Quetglas   WORLD JOURNAL OF GASTROENTEROLOGY

CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case–control study

(2015) Hua Ye et al.   ARTHRITIS RESEARCH & THERAPY

A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation

(2015) Judith Wienke et al.   Oncotarget

The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis

(2015) Akira Sato et al.   Scientific Reports

Expression of Wnt and Notch signaling pathways in inflammatory bowel disease treated with mesenchymal stem cell transplantation: evaluation in a rat model

(2015) Yanfen Xing et al.   Stem Cell Research & Therapy

The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus

(2015) Shuangyan Luo et al.   Clinical Epigenetics

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

(2015) A. Holtzhausen et al.   Cancer Immunology Research

Receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin system in bone and other tissues (Review)

(2015) WEI LIU et al.   Molecular Medicine Reports

WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer

(2015) Annalucia Serafino et al.   Oncotarget

MicroRNA expression profiles of peripheral blood mononuclear cells in patients with systemic lupus erythematosus

(2014) Dongmei Liu et al.   ACTA HISTOCHEMICA

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

(2014) Julia Beisner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders

(2014) Pooja M. Bhatt et al.   ATHEROSCLEROSIS

MicroRNA-152 modulates the canonical Wnt pathway activation by targeting DNA methyltransferase 1 in arthritic rat model

(2014) Cheng-gui Miao et al.   BIOCHIMIE

Wnt signaling in ankylosing spondylitis

(2014) Maripat Corr   CLINICAL RHEUMATOLOGY

Mechanisms of autoimmunity in human diseases

(2014) Robert A. Benson et al.   CURRENT OPINION IN RHEUMATOLOGY

Extracellular modulators of Wnt signalling

(2014) Tomas Malinauskas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle

(2014) Liye Suo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The immune potential and immunopathology of cytokine-producing B cell subsets: A comprehensive review

(2014) Yan Bao et al.   JOURNAL OF AUTOIMMUNITY

Impaired B Cell Inhibition by Lupus Bone Marrow Mesenchymal Stem Cells Is Caused by Reduced CCL2 Expression

(2014) Nan Che et al.   JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus and lupus nephritis

(2014) Toli Koutsokeras et al.   NATURE REVIEWS DRUG DISCOVERY

Aberrant Activation of the WNT/β-Catenin Signaling Pathway in Lupus Nephritis

(2014) Xiao-dong Wang et al.   PLoS One

Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions

(2014) Fanhua Wei et al.   PLoS One

Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets

(2014) D. E. Furst et al.   RHEUMATOLOGY

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

(2014) S. Svegliati et al.   Science Signaling

Preliminary mechanism on the methylation modification of Dkk-1 and Dkk-3 in hepatocellular carcinoma

(2014) Libo Liang et al.   TUMOR BIOLOGY

WNT signaling in bone development and homeostasis

(2014) Zhendong Zhong et al.   Wiley Interdisciplinary Reviews-Developmental Biology

CTLA-4Ig-Induced T Cell Anergy Promotes Wnt-10b Production and Bone Formation in a Mouse Model

(2014) Susanne Roser-Page et al.   Arthritis & Rheumatology

Effect of TNFα on osteoblastogenesis from mesenchymal stem cells

(2013) Shigeru Kotake et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Chronic ulcerative colitis and colorectal cancer

(2013) Gerhard Rogler   CANCER LETTERS

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

(2013) Cheng-gui Miao et al.   CELLULAR SIGNALLING

Treating skin and lung fibrosis in systemic sclerosis: a future filled with promise?

(2013) Milos Antic et al.   CURRENT OPINION IN PHARMACOLOGY

What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis?

(2013) Shervin Assassi et al.   CURRENT OPINION IN RHEUMATOLOGY

Altered expression of atypical PKC and Ryk in the spinal cord of a mouse model of amyotrophic lateral sclerosis

(2013) Anna Tury et al.   Developmental Neurobiology

Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function

(2013) Jorg van Loosdregt et al.   IMMUNITY

Canonical and Noncanonical Wnt Proteins Program Dendritic Cell Responses for Tolerance

(2013) C. Oderup et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenic mechanisms of systemic autoimmune disease

(2013) Marie Wahren-Herlenius et al.   LANCET

Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway

(2013) Zhifeng Gu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression

(2013) Hozefa S Bandukwala et al.   NATURE IMMUNOLOGY

Epigenetic silencing of Wnt inhibition in systemic sclerosis

(2013) Emma Leah   Nature Reviews Rheumatology

M2 Macrophages Activate WNT Signaling Pathway in Epithelial Cells: Relevance in Ulcerative Colitis

(2013) Jesús Cosín-Roger et al.   PLoS One

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

(2013) C. Lamagna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple functions of the noncanonical Wnt pathway

(2013) Eva Gómez-Orte et al.   TRENDS IN GENETICS

Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis

(2013) Ying Tan et al.   BMC Nephrology

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

(2012) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-α in human mesenchymal stem cells

(2012) A. Briolay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats

(2012) Cheng-gui Miao et al.   CELLULAR SIGNALLING

The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation

(2012) Yoon-Sook Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells

(2012) I. Gyory et al.   GENES & DEVELOPMENT

Common and specific signatures of gene expression and protein–protein interactions in autoimmune diseases

(2012) T Tuller et al.   GENES AND IMMUNITY

Adalimumab significantly reduces inflammation and serum DKK-1 level but increases fatty deposition in lumbar spine in active ankylosing spondylitis

(2012) Zaiying Hu et al.   International Journal of Rheumatic Diseases

Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis

(2012) Baodong Qin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation

(2012) Jian Ma et al.   Journal of Neuroimmune Pharmacology

Wnt Signaling in the Pathogenesis of Multiple Sclerosis-Associated Chronic Pain

(2012) Subo Yuan et al.   Journal of Neuroimmune Pharmacology

Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2

(2012) Stefanie M. Hauck et al.   Journal of Proteomics

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

(2012) Maureen J. Koslowski et al.   PLoS Genetics

High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis

(2011) Gisela Ruiz Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

miRNA-146a in rheumatoid arthritis: a new therapeutic strategy

(2011) Kaleb M Pauley et al.   Immunotherapy

Wnt5a Skews Dendritic Cell Differentiation to an Unconventional Phenotype with Tolerogenic Features

(2011) Jaris Valencia et al.   JOURNAL OF IMMUNOLOGY

Activation of Wnt Signaling Arrests Effector Differentiation in Human Peripheral and Cord Blood-Derived T Lymphocytes

(2011) Sujatha Muralidharan et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-449a Overexpression, Reduced NOTCH1 Signals and Scarce Goblet Cells Characterize the Small Intestine of Celiac Patients

(2011) Marina Capuano et al.   PLoS One

Dickkopf-1 level is lower in patients with ankylosing spondylitis than in healthy people and is not influenced by anti-tumor necrosis factor therapy

(2011) Seong-Ryul Kwon et al.   RHEUMATOLOGY INTERNATIONAL

The Emerging Role of Dickkopf-1 in Bone Biology: Is It the Main Switch Controlling Bone and Joint Remodeling?

(2011) Dimitrios Daoussis et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development

(2010) Anders Aune Tveita et al.   ARTHRITIS AND RHEUMATISM

Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

(2010) A B Coda et al.   GENES AND IMMUNITY

Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells

(2010) K. R. Hughes et al.   INFLAMMATORY BOWEL DISEASES

Dickkopf-1 as Potential Biomarker to Evaluate Bone Erosion in Systemic Lupus Erythematosus

(2010) Li Long et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Evidence for Altered Wnt Signaling in Psoriatic Skin

(2010) Johann E. Gudjonsson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effector T cells driving monophasic vs. relapsing/remitting experimental autoimmune uveitis show unique pathway signatures

(2010) Christine von Toerne et al.   MOLECULAR IMMUNOLOGY

Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus

(2010) Y.-J. Sheng et al.   RHEUMATOLOGY

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

(2010) Takayoshi Yamaza et al.   Stem Cell Research & Therapy

WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis

(2009) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints

(2009) S. Uderhardt et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis

(2009) Dimitrios Daoussis et al.   ARTHRITIS AND RHEUMATISM

WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

(2009) Melanie Königshoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Promising bone-related therapeutic targets for rheumatoid arthritis

(2009) Yongwon Choi et al.   Nature Reviews Rheumatology

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

(2009) Maureen J. Koslowski et al.   PLoS One

Wnt5a Exhibits Layer-Specific Expression in Adult Skin, Is Upregulated in Psoriasis, and Synergizes with Type 1 Interferon

(2009) Malgorzata Romanowska et al.   PLoS One

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

The role of Dickkopf-1 in bone development, homeostasis, and disease

(2008) J. J. Pinzone et al.   BLOOD

MicroRNAs - micro in size but macro in function

(2008) Sunit K. Singh et al.   FEBS Journal

Epigenetic Regulation of WNT Signaling Pathway Genes in Inflammatory Bowel Disease (IBD) Associated Neoplasia

(2008) Mashaal Dhir et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

(2008) Yi Ding et al.   NATURE MEDICINE

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

(2008) T. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Wnt proteins in arthritis

(2008) Georg Schett et al.   Nature clinical practice. Rheumatology