A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

In silicoPrediction of Drug Induced Liver Toxicity Using Substructure Pattern Recognition Method

(2016) Chen Zhang et al.   Molecular Informatics

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

(2015) Mathieu Vinken   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data

(2015) Fabiola Pizzo et al.   Chemistry Central Journal

Toward predictive models for drug-induced liver injury in humans: are we there yet?

(2014) Minjun Chen et al.   Biomarkers in Medicine

A new in silico classification model for ready biodegradability, based on molecular fragments

(2014) Anna Lombardo et al.   CHEMOSPHERE

Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats

(2014) Yutaka Tonomura et al.   JOURNAL OF APPLIED TOXICOLOGY

A generalizable definition of chemical similarity for read-across

(2014) Matteo Floris et al.   Journal of Cheminformatics

Predicting idiosyncratic drug-induced liver injury – some recent advances

(2014) Minjun Chen et al.   Expert Review of Gastroenterology & Hepatology

Chemotherapy-Induced Hepatotoxicity

(2013) Ameet V. Thatishetty et al.   Clinics in Liver Disease

Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action

(2013) M. Hewitt et al.   CRITICAL REVIEWS IN TOXICOLOGY

Automatic knowledge extraction from chemical structures: the case of mutagenicity prediction

(2013) T. Ferrari et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Quantitative Structure-Activity Relationship Models for Predicting Drug-Induced Liver Injury Based on FDA-Approved Drug Labeling Annotation and Using a Large Collection of Drugs

(2013) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study

(2012) J. M. Paterson et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Optimally discriminative subnetwork markers predict response to chemotherapy

(2011) P. Dao et al.   BIOINFORMATICS

Clinical and Histopathologic Features of Fluoroquinolone-Induced Liver Injury

(2011) Eric S. Orman et al.   Clinical Gastroenterology and Hepatology

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The potential of cytokines as safety biomarkers for drug-induced liver injury

(2010) Hugh G. Laverty et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species

(2009) Denis Fourches et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An Expert System Approach to the Assessment of Hepatotoxic Potential

(2009) Carol A. Marchant et al.   CHEMISTRY & BIODIVERSITY

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury

(2009) O. F. Laterza et al.   CLINICAL CHEMISTRY

Drug-Induced Hepatotoxicity or Drug-Induced Liver Injury

(2009) Aaron J. Pugh et al.   Clinics in Liver Disease

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Protective effect of bile acid derivatives in phalloidin-induced rat liver toxicity

(2009) Elisa Herraez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In silico toxicology for the pharmaceutical sciences☆

(2009) Luis G. Valerio Jr.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Maximum-Likelihood Estimation of Predictive Uncertainty in Probabilistic QSAR Modeling

(2009) Alexandre Pery et al.   Quantitative structure-activity relationships & combinatorial science

A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state

(2008) C. L. O’Bryant et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Computational toxicology in drug development

(2008) Wolfgang Muster et al.   DRUG DISCOVERY TODAY

Drug-related Hepatotoxicity and Acute Liver Failure

(2008) Karen F Murray et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

(2008) Eric A.G. Blomme et al.   TOXICOLOGY LETTERS

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY