Article
Gastroenterology & Hepatology
Jieting Tang, Jin Gu, Naihui Chu, Yu Chen, Yongliang Wang, Dongying Xue, Qing Xie, Lei Li, Zaoxian Mei, Xiaojin Wang, Jun Li, Jun Chen, Yi Li, Changqing Yang, Yingxin Wang, Jia Shang, Wen Xie, Peng Hu, Dongliang Li, Limin Zhao, Pei Lan, Chen Wang, Chengwei Chen, Yimin Mao
Summary: This study investigated the efficacy and safety of bicyclol in acute drug-induced liver injury. The results showed that bicyclol reduced ALT levels and improved ALT normalization rates, with no significant difference in safety compared to the control group.
LIVER INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Alison Jee, Samantha Christine Sernoskie, Jack Uetrecht
Summary: IDILI remains a significant problem for patients and drug development due to its idiosyncratic nature. Most cases of IDILI are likely caused by reactive metabolites of drugs and mediated by the adaptive immune system, with some associations with specific human leukocyte antigen haplotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Mercedes Robles-Diaz, Lana Nezic, Vesna Vujic-Aleksic, Einar S. Bjornsson
Summary: UDCA may have some benefits in the treatment and prevention of DILI according to available data, but a well designed RCT is needed to draw a firm conclusion on its efficacy in DILI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edmond Atallah, Cristiana Freixo, Ismael Alvarez-Alvarez, F. J. Cubero, Alexander L. Gerbes, Gerd A. Kullak-Ublick, Guruprasad P. Aithal
Summary: This systematic review presents the available evidence for biomarkers in the diagnosis or prognosis of DILI, highlighting the heterogeneity in diagnostic studies and the improved prognostic ability when integrating novel and traditional biomarkers in prognostic models.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Robert J. Fontana, Einar S. Bjornsson, Rajender Reddy, Raul J. Andrade
Summary: Idiosyncratic drug-induced liver injury (DILI) is a rare but significant cause of liver disease. Newly identified causes of DILI include COVID vaccines, turmeric, green tea extract, and immune checkpoint inhibitors. DILI is diagnosed through exclusion, requiring evaluation for more common causes and a temporal association with the suspected drug. Advances in DILI causality assessment and drug-specific HLA associations have improved diagnosis and prognosis. LiverTox provides important information on the hepatotoxicity profile of medications and supplements.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Hyun Yang, Ji Won Han, Jae Jun Lee, Ahlim Lee, Sung Woo Cho, Pu Reun Rho, Min-Woo Kang, Jeong Won Jang, Eun Sun Jung, Jong Young Choi, Pil Soo Sung, Si Hyun Bae
Summary: This study investigated the phenotypes and clinical implications of liver-infiltrating immune cells in idiosyncratic drug-induced liver injury (DILI). The results showed that activated CD8+ T cells and mononuclear phagocytes are associated with drug-induced liver injury. Therefore, steroids are suggested as a potential treatment option for idiosyncratic DILI.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Environmental Sciences
Rebecca Allison, Asha Guraka, Isaac Thom Shawa, Gyan Tripathi, Wolfgang Moritz, Ali Kermanizadeh
Summary: This review primarily focuses on the mechanisms, risk factors, and the impact of the coronavirus pandemic on idiosyncratic drug-induced liver injury (DILI). Although some molecular mechanisms are known, the underlying mechanisms responsible for DILI are still unknown. Prevention strategies are crucial due to limited treatment options once the injury has occurred.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Rolf Teschke, Gaby Danan
Summary: Progress has been made in understanding the mechanisms of idiosyncratic drug-induced liver injury (iDILI) worldwide, with the identification of metabolic risk factors. However, uncertainty remains regarding the prediction of iDILI, with controversies surrounding certain risks factors such as drug doses and hepatic drug metabolism. Further research is needed to address these methodological flaws and establish stronger evidence for risk factors of iDILI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Binbin Lv, Longshan Liu, Xiaoman Liu, Min Huang, Xiao Chen, Kejing Tang, Changxi Wang, Pan Chen
Summary: In this study, the occurrence of tacrolimus-induced liver injury (tac-DILI) in renal transplant recipients was investigated. The most common type of tac-DILI was found to be the cholestatic pattern. Baseline ALP level, age, and body weight were identified as independent risk factors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengmeng Lin, Yingying Li, Bo Cao, Jing Xu, Yujun Zhang, Guohui Li, Xiaohe Xiao, Chunyu Li
Summary: This study found that bavachin and epimedin B caused significant liver injury under immunological stress conditions, and resulted in differential gene expression related to liver metabolism and immune system processes. The combination of bavachin and epimedin B not only affected immune system processes, but also lipid metabolism, leading to an imbalance in the immune microenvironment in the liver.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Robert A. Roth, Omar Kana, David Filipovic, Patricia E. Ganey
Summary: Hypotheses explaining the etiology of IDILI all involve changes in pharmacokinetics, which result in higher plasma drug concentrations or alterations in toxicodynamics that lower the toxicity threshold. Changes in pharmacokinetics can arise from alterations in drug metabolism or transporter polymorphisms. A lowered toxicity threshold may be caused by drug-induced mitochondrial injury, accumulation of toxic endogenous factors, or harmful immune responses. The newly developed interactive freeware, DemoTox-PK, allows users to visualize how these alterations can lead to a toxic reaction. The provided illustrations provide a framework for understanding idiosyncratic reactions and can stimulate further discussion, education, and research into the modes of action of IDILI.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tsuyoshi Yokoi, Shingo Oda
Summary: Drug-induced liver injury (DILI) is a major concern during drug development and post-marketing, with both intrinsic and idiosyncratic classifications. Predicting idiosyncratic DILI, associated with severe liver damage, is challenging due to its low incidence and complex nature. Animal models have been used to study DILI mechanisms and predict potential risks.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Gastroenterology & Hepatology
Yan Wang, Cailun Zou, Aileen Wee, Jimin Liu, Zikun Ma, Tiantian Guo, Min Li, Yu Wang, Liwei Liu, Jidong Jia, Zhengsheng Zou, Xinyan Zhao
Summary: This study compares several models for predicting mortality in patients with drug-induced liver injury. The MELD Score and Ghabril Model were found to have the best predictive performance in predicting mortality within 12 months after DILI onset.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Bernd Rattay, Ralf A. Benndorf
Summary: Drug-induced agranulocytosis is a life-threatening side effect that can be triggered by various drugs, characterized by idiosyncratic reactions and a low incidence rate. It is thought to be initiated by chemically reactive drugs or metabolites that elicit an immune response, affecting cells or organs with specific metabolic activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yan Wang, Guang Xu, Zhilei Wang, Ruisheng Li, Xiaoyan Zhan, Hongbin Liu, Qin Qin, Weixia Li, Xiaoyan Wang, Mingliang Zhang, Jinfa Tang, Zhaofang Bai, Xiaohe Xiao
Summary: This study found that psoralidin from Psoraleae Fructus induces idiosyncratic drug-induced liver injury (IDILI) by activating inflammasomes. The results suggest that psoralidin can activate not only the NLRP3 inflammasome but also other types of inflammasomes. The study further revealed the mechanism of liver injury induced by psoralidin.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Leihong Wu, Zhichao Liu, Joshua Xu, Minjun Chen, Hong Fang, Weida Tong, Wenming Xiao
BIOMARKERS IN MEDICINE
(2015)
Article
Chemistry, Medicinal
Jie Liu, Kamel Mansouri, Richard S. Judson, Matthew T. Martin, Huixiao Hong, Minjun Chen, Xiaowei Xu, Russell S. Thomas, Imran Shah
CHEMICAL RESEARCH IN TOXICOLOGY
(2015)
Review
Gastroenterology & Hepatology
Minjun Chen, Ayako Suzuki, Juergen Borlak, Raul J. Andrade, M. Isabel Lucena
JOURNAL OF HEPATOLOGY
(2015)
Review
Pharmacology & Pharmacy
Minjun Chen, Ayako Suzuki, Shraddha Thakkar, Ke Yu, Chuchu Hu, Weida Tong
DRUG DISCOVERY TODAY
(2016)
Article
Gastroenterology & Hepatology
Minjun Chen, Juergen Borlak, Weida Tong
Review
Biotechnology & Applied Microbiology
Franck A. Atienzar, Eric A. Blomme, Minjun Chen, Philip Hewitt, J. Gerry Kenna, Gilles Labbe, Frederic Moulin, Francois Pognan, Adrian B. Roth, Laura Suter-Dick, Okechukwu Ukairo, Richard J. Weaver, Yvonne Will, Donna M. Dambach
BIOMED RESEARCH INTERNATIONAL
(2016)
Editorial Material
Gastroenterology & Hepatology
Poonam Mishra, Minjun Chen
Article
Biochemistry & Molecular Biology
Kristin McEuen, Juergen Borlak, Weida Tong, Minjun Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Chemistry, Medicinal
Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, Weida Tong
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2017)
Review
Gastroenterology & Hepatology
Shraddha Thakkar, Minjun Chen, Hong Fang, Zhichao Liu, Ruth Roberts, Weida Tong
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2018)
Editorial Material
Biotechnology & Applied Microbiology
Eileen E. N. Almario, Juergen Borlak, Ayako Suzuki, Minjun Chen
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Huixiao Hong, Shraddha Thakkar, Minjun Chen, Weida Tong
SCIENTIFIC REPORTS
(2017)
Article
Environmental Sciences
Roland Moore, Kristin Ashby, Tsung-Jen Liao, Minjun Chen
Summary: Drug-induced liver injury (DILI) is a major issue in drug development and approval processes. Genetic variants play a significant role in individual responses to drugs, and machine learning approaches such as Multivariate Adaptive Regression Splines (MARS) and Multifactor Dimensionality Reduction (MDR) can help identify gene-gene interactions as potential risk factors for assessing complex diseases like DILI.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Andres Gonzalez-Jimenez, Ayako Suzuki, C. Stephens, Minjun Chen, I. Medina-Caliz, Mercedes Robles Diaz, Martin Prieto, German Soriano, Eva Montane, A. Aldea, Raul J. Andrade, M. I. Lucena
Review
Chemistry, Medicinal
Yu-feng Liu, Ni Ai, Anthony Keys, Xiao-hui Fan, Min-jun Chen
CHINESE HERBAL MEDICINES
(2015)