Quantitative Structure-Activity Relationship Models for Predicting Drug-Induced Liver Injury Based on FDA-Approved Drug Labeling Annotation and Using a Large Collection of Drugs

Avoiding idiosyncratic DILI: Two is better than one

(2013) Neil Kaplowitz   HEPATOLOGY

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

(2012) Craig E Thomas et al.   Expert Opinion on Drug Discovery

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data

(2012) Ivan Rusyn et al.   TOXICOLOGICAL SCIENCES

A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science

(2012) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

Selecting a single model or combining multiple models for microarray-based classifier development? – A comparative analysis based on large and diverse datasets generated from the MAQC-II project

(2011) Minjun Chen et al.   BMC BIOINFORMATICS

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

(2011) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?

(2011) Min Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug Safety Sciences and the Bottleneck in Drug Development

(2011) P B Watkins   CLINICAL PHARMACOLOGY & THERAPEUTICS

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Advancing Regulatory Science

(2011) M. A. Hamburg   SCIENCE

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

(2011) Zhichao Liu et al.   PLoS Computational Biology

Modeling Liver-Related Adverse Effects of Drugs UsingkNearest Neighbor Quantitative Structure−Activity Relationship Method

(2010) Amie D. Rodgers et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury

(2010) S. Ekins et al.   DRUG METABOLISM AND DISPOSITION

Computational toxicology—a tool for early safety evaluation

(2009) Cédric Merlot   DRUG DISCOVERY TODAY

Computational toxicology in drug development

(2008) Wolfgang Muster et al.   DRUG DISCOVERY TODAY

Mold2, Molecular Descriptors from 2D Structures for Chemoinformatics and Toxicoinformatics

(2008) Huixiao Hong et al.   Journal of Chemical Information and Modeling

Acute Liver Failure Due to Drugs

(2008) Robert Fontana   SEMINARS IN LIVER DISEASE

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES