Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

Cytosine arabinoside potentiates the apoptotic effect of bendamustine on several B- and T-cell leukemia/lymphoma cells and cell lines

(2012) Silvia Castegnaro et al.   LEUKEMIA & LYMPHOMA

A Large Population Histology Study Showing the Lack of Association between ALT Elevation and Significant Fibrosis in Chronic Hepatitis B

(2012) Wai-Kay Seto et al.   PLoS One

The Development of Structure-Activity Relationships for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

(2012) Russell T. Naven et al.   TOXICOLOGICAL SCIENCES

Severe hepatotoxicity and probable hepatorenal syndrome associated with sulfadiazine

(2011) H. Khalili et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Influence of tamoxifen on gluconeogenesis and glycolysis in the perfused rat liver

(2011) Carla Brugin Marek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

(2011) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Review of liver injury associated with dietary supplements

(2011) Felix Stickel et al.   LIVER INTERNATIONAL

Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

(2011) Jin-Woo Jeong et al.   TOXICOLOGY IN VITRO

On the mechanisms of phenothiazine-induced mitochondrial permeability transition: Thiol oxidation, strict Ca 2+ dependence, and cyt c release

(2010) Thiago S. Cruz et al.   BIOCHEMICAL PHARMACOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

(2010) Jerome Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Regulation of hepatic blood flow: The hepatic arterial buffer response revisited

(2010) Christian Eipel   WORLD JOURNAL OF GASTROENTEROLOGY

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

(2009) Jonathon N. Bauman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species

(2009) Denis Fourches et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity--Two Villains or One?

(2009) R. A. Roth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

(2009) Leos Fuksa et al.   TOXICOLOGY

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Investigations into the liver effects of ximelagatran using high content screening of primary human hepatocyte cultures

(2008) Edward K Ainscow et al.   Expert Opinion On Drug Safety

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran

(2007) Kerstin Kenne et al.   TOXICOLOGY IN VITRO