Revisiting caspases in sepsis

Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

(2014) Tom Vanden Berghe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

(2014) Zhongshuang Hu et al.   PLoS One

Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

(2014) Matthew C. Exline et al.   PLoS One

The new normal: immunomodulatory agents against sepsis immune suppression

(2014) Noelle A. Hutchins et al.   TRENDS IN MOLECULAR MEDICINE

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

An Inactivating Caspase-11 Passenger Mutation Muddles Sepsis Research

(2013) Tom Vanden Berghe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

(2013) Jianfeng Wu et al.   CELL RESEARCH

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture

(2013) Kristel Demeyere et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

(2012) Niall S. Kenneth et al.   BIOCHEMICAL JOURNAL

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

Milk Fat Globule-Epidermal Growth Factor-Factor 8 Attenuates Neutrophil Infiltration in Acute Lung Injury via Modulation of CXCR2

(2012) M. Aziz et al.   JOURNAL OF IMMUNOLOGY

Current trends in inflammatory and immunomodulatory mediators in sepsis

(2012) M. Aziz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Novel Therapeutic Targets for Sepsis: Regulation of Exaggerated Inflammatory Responses

(2012) Akihisa Matsuda et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recombinant human MFG-E8 attenuates cerebral ischemic injury: Its role in anti-inflammation and anti-apoptosis

(2011) Cletus Cheyuo et al.   NEUROPHARMACOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DEFICIENCY OF BID PROTEIN REDUCES SEPSIS-INDUCED APOPTOSIS AND INFLAMMATION, WHILE IMPROVING SEPTIC SURVIVAL

(2010) Chun-Shiang Chung et al.   SHOCK

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

(2009) M. Lamkanfi et al.   BLOOD

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY