Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

(2016) Kuo-Hui Su et al.   NATURE CELL BIOLOGY

Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment

(2016) Paola C. Rosas et al.   PLoS One

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

(2015) Zijian Tang et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α

(2015) Neri Minsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifaceted roles of HSF1 in cancer

(2015) Sufang Jiang et al.   TUMOR BIOLOGY

AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease

(2014) Tz-Chuen Ju et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1

(2014) Swasti Raychaudhuri et al.   CELL

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

(2014) Darren C. Henstridge et al.   DIABETES

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

(2014) S. Dai et al.   EMBO JOURNAL

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

(2014) Pramod Aryal et al.   FEBS Journal

Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival

(2014) Alexandra N. Elsing et al.   JOURNAL OF CELL BIOLOGY

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid  

(2014) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Bis is Induced by Oxidative StressviaActivation of HSF1

(2014) Hyung Jae Yoo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Improvement of Insulin Sensitivity by a Novel Drug Candidate, BGP-15, in Different Animal Studies

(2014) Botond Literáti-Nagy et al.   Metabolic Syndrome and Related Disorders

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

(2014) Ryosuke Takii et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolism in HD: Still a relevant mechanism?

(2014) Wenzhen Duan et al.   MOVEMENT DISORDERS

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

(2013) Yu-Qing Jiang et al.   BRAIN RESEARCH

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

(2013) Brian G. Drew et al.   DIABETES

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

(2013) Tetsuro Marunouchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart

(2013) Jean-Louis Guéant et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

(2013) Naohide Kondo et al.   Nature Communications

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Obesity and cancer risk: evidence, mechanisms, and recommendations

(2012) Ivana Vucenik et al.   Annals of the New York Academy of Sciences

Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging

(2012) János Barna et al.   BMC DEVELOPMENTAL BIOLOGY

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

(2012) Wei-Chung Chiang et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Heat shock factor 1 is inactivated by amino acid deprivation

(2012) Sanne M. M. Hensen et al.   CELL STRESS & CHAPERONES

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

(2012) Josianne Rodrigues-Krause et al.   CELL STRESS & CHAPERONES

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic  -Cells From Cell Stresses and Apoptosis

(2012) T. Kondo et al.   DIABETES

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

(2012) Luigi Racioppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

(2012) Chengkai Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced antitumoral efficacy and immune response following conditionally replicative adenovirus containing constitutive HSF1 delivery to rodent tumors

(2012) Rong Fan et al.   Journal of Translational Medicine

Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin

(2012) Sidhartha M. Chafekar et al.   PLoS One

In vitro salicylate does not further impair aging-induced brain mitochondrial dysfunction

(2012) I. Marques-Aleixo et al.   TOXICOLOGY

Metabolic Stress in Autophagy and Cell Death Pathways

(2012) B. J. Altman et al.   Cold Spring Harbor Perspectives in Biology

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Heat shock transcription factors and sensory placode development

(2011) Akira Nakai   BMB Reports

Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic Syndrome

(2011) Xiongjie Jin et al.   Cell Metabolism

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis

(2011) Chengkai Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

(2011) W van Veelen et al.   ONCOGENE

Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation

(2011) Yue Zhang et al.   PLoS One

The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms

(2011) T. Gidalevitz et al.   Cold Spring Harbor Perspectives in Biology

Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis

(2011) S. L. Lindquist et al.   Cold Spring Harbor Perspectives in Biology

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Heat Shock Connection of Metabolic Stress and Dietary Restriction

(2010) Balazs Dancso et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

(2010) R. J. Kaufman et al.   DIABETES OBESITY & METABOLISM

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

(2010) Naoki Hayashida et al.   EMBO JOURNAL

Heat Shock Proteins Are Important Mediators of Skeletal Muscle Insulin Sensitivity

(2010) Paige C. Geiger et al.   EXERCISE AND SPORT SCIENCES REVIEWS

The heat shock factor family and adaptation to proteotoxic stress

(2010) Mitsuaki Fujimoto et al.   FEBS Journal

Heat Shock Transcription Factor 1 Localizes to Sex Chromatin during Meiotic Repression

(2010) Malin Åkerfelt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial biology in Alzheimer’s disease pathogenesis

(2010) María F. Galindo et al.   JOURNAL OF NEUROCHEMISTRY

Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion

(2010) Tsuyoshi Uchiyama et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

(2010) Daniel W. Neef et al.   PLOS BIOLOGY

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Heat Shock Protein 27 Overexpression Mitigates Cytokine-Induced Islet Apoptosis and Streptozotocin-Induced Diabetes

(2009) Tiane Dai et al.   ENDOCRINOLOGY

Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial

(2009) B. Literáti-Nagy et al.   HORMONE AND METABOLIC RESEARCH

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

(2009) J. L. Wacker et al.   JOURNAL OF NEUROSCIENCE

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock

(2009) Mitsuaki Fujimoto et al.   MOLECULAR BIOLOGY OF THE CELL

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

(2009) M Brunet Simioni et al.   ONCOGENE

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys

(2008) K. Kavanagh et al.   CELL STRESS & CHAPERONES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation

(2008) Yuxing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

(2008) L. Mosconi et al.   NEUROLOGY

Increased amyloid β-peptide (1–40) level in brain of streptozotocin-induced diabetic rats

(2008) Y. Liu et al.   NEUROSCIENCE

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death

(2008) Yusuke Nakatsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY