One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats

(2015) Loqman A. Mohamed et al.   ACS Chemical Neuroscience

The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer’s Disease

(2015) William James Deardorff et al.   DRUGS & AGING

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

(2015) Christophe Rochais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling

(2015) Xiangyou Hu et al.   JOURNAL OF NEUROCHEMISTRY

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234

(2014) Javier del Pino et al.   CNS Neuroscience & Therapeutics

The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1

(2014) Patty Kandalepas et al.   Current Alzheimer Research

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

(2014) M. Carreiras et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

(2014) Oscar M. Bautista-Aguilera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis

(2014) Shu-huai Xing et al.   Evidence-based Complementary and Alternative Medicine

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

(2014) Haibin Liu et al.   Journal of Chemical Information and Modeling

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor

(2014) Oscar M. Bautista-Aguilera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Repositioning Approaches for the Discovery of New Therapeutics for Alzheimer’s Disease

(2014) Tae-Wan Kim   Neurotherapeutics

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

(2014) C. Lecoutey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance-resistant antibiotics

(2014) Eric Oldfield et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

(2014) F. Prati et al.   MedChemComm

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

(2013) Lirong Wang et al.   AAPS Journal

Multipotent, Permeable Drug ASS234 Inhibits Aβ Aggregation, Possesses Antioxidant Properties and Protects from Aβ-induced Apoptosis In Vitro

(2013) Irene Bolea et al.   Current Alzheimer Research

A novel series of tacrine–selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease

(2013) Chuanjun Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

(2013) Su-Yi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

(2013) Christian Hölscher   JOURNAL OF ENDOCRINOLOGY

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Multi Target Neuroprotective and Neurorestorative Anti-Parkinson and Anti-Alzheimer Drugs Ladostigil and M30 Derived from Rasagiline

(2013) Moussa B.H. Youdim   Experimental Neurobiology

TD-1792 versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections

(2012) Martin E. Stryjewski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MBX-500, a Hybrid Antibiotic withIn VitroandIn VivoEfficacy against Toxigenic Clostridium difficile

(2012) Michelle M. Butler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, molecular modeling and evaluation of novel N′-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation

(2012) Eda Özturan Özer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

(2012) Kerry Hunter et al.   BMC NEUROSCIENCE

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

(2012) Abdelouahid Samadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multitarget ligands in antibacterial research: progress and opportunities

(2012) Stephen P East et al.   Expert Opinion on Drug Discovery

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

(2011) Huang Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

(2011) Michela Rosini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

(2011) Carles Galdeano et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Neuroprotective therapeutics for Alzheimer's disease: progress and prospects

(2011) Alan M. Palmer   TRENDS IN PHARMACOLOGICAL SCIENCES

Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy

(2010) Hailin Zheng et al.   ACS Chemical Biology

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

(2010) Simon Gengler et al.   NEUROBIOLOGY OF AGING

Site-Activated Chelators Derived from Anti-Parkinson Drug Rasagiline as a Potential Safer and More Effective Approach to the Treatment of Alzheimer’s Disease

(2010) Hailin Zheng et al.   NEUROCHEMICAL RESEARCH

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels

(2010) Cecilie Löe Licht et al.   NEUROSCIENCE LETTERS

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

(2010) Orly Weinreb et al.   PROGRESS IN NEUROBIOLOGY

Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

(2009) Hong-Fang Ji et al.   EMBO REPORTS

Design, Synthesis, and Biological Evaluation of New 5-HT4Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

(2009) Olivier Russo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repurposing with a Difference

(2009) M. S. Boguski et al.   SCIENCE

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING