Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling

Serotonin in antipsychotic drugs action

(2015) Davide Amato   BEHAVIOURAL BRAIN RESEARCH

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Epigenetic signaling in schizophrenia

(2015) Daisuke Ibi et al.   CELLULAR SIGNALLING

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

(2015) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Epigenetic mechanisms in schizophrenia

(2015) Kimberly R. Shorter et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia

(2015) Samuel M. Cohen et al.   SCHIZOPHRENIA RESEARCH

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling

(2015) Detlef Vullhorst et al.   Nature Communications

Structural biology of presenilin 1 complexes

(2015) Yi Li et al.   Molecular Neurodegeneration

The ErbB4 Ligand Neuregulin-4 Protects against Experimental Necrotizing Enterocolitis

(2014) Steven J. McElroy et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuregulin Signaling in Pieces—Evolution of the Gene Family

(2014) Mark Marchionni   CURRENT PHARMACEUTICAL DESIGN

β-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) Regulates Notch Signaling by Controlling the Cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) Proteins

(2014) Wanxia He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain

(2014) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Molecular neurodegeneration: basic biology and disease pathways

(2014) Robert Vassar et al.   Molecular Neurodegeneration

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

(2014) Xiaoyan Hu et al.   Molecular Neurodegeneration

BACE1 activity regulates cell surface contactin-2 levels

(2014) Vivek Gautam et al.   Molecular Neurodegeneration

Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

(2014) Katherine A Price et al.   Molecular Neurodegeneration

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Calcyon stimulates neuregulin 1 maturation and signaling

(2014) D-M Yin et al.   MOLECULAR PSYCHIATRY

Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia

(2014) A Banerjee et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory

(2014) Yisheng Lu et al.   NEURON

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

NMDA receptor hypofunction and the thalamus in schizophrenia

(2014) Zoran Vukadinovic   PHYSIOLOGY & BEHAVIOR

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity

(2014) Amit Agarwal et al.   Cell Reports

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

A new single gene deletion on 2q34:ERBB4is associated with intellectual disability

(2013) Jurate Kasnauskiene et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

(2013) Xiaoyang Luo et al.   BIOLOGICAL PSYCHIATRY

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination

(2013) Florence R. Fricker et al.   BRAIN

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

(2013) Cyril Cheret et al.   EMBO JOURNAL

Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF–CREB-binding site

(2013) Carter A. Herndon et al.   EXPERIMENTAL CELL RESEARCH

Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression

(2013) Xiangyou Hu et al.   FASEB JOURNAL

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

(2013) Carolyn C. Sachse et al.   FASEB JOURNAL

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

(2013) Frauke van Bebber et al.   JOURNAL OF NEUROCHEMISTRY

Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

(2013) D. Fleck et al.   JOURNAL OF NEUROSCIENCE

The Erk MAP kinase pathway is activated at muscle spindles and is required for induction of the muscle spindle-specific gene Egr3 by neuregulin1

(2013) Carter A. Herndon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Overcoming barriers and thresholds -- signaling of oligomeric Abeta through the prion protein to Fyn

(2013) Hansen Wang et al.   Molecular Neurodegeneration

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Reversal of Behavioral Deficits and Synaptic Dysfunction in Mice Overexpressing Neuregulin 1

(2013) Dong-Min Yin et al.   NEURON

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

(2013) Melissa A. Snyder et al.   Frontiers in Cellular Neuroscience

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

(2013) Xiangyou Hu et al.   Cell Reports

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Genetic disruption ofPtenin a novel mouse model of tomaculous neuropathy

(2012) Sandra Goebbels et al.   EMBO Molecular Medicine

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo

(2012) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuregulin-4 Is a Survival Factor for Colon Epithelial Cells both in Culture andin Vivo

(2012) Jessica K. Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

A role for Schwann cell–derived neuregulin-1 in remyelination

(2012) Ruth M Stassart et al.   NATURE NEUROSCIENCE

Twenty-five Years of Glutamate in Schizophrenia: Are We There Yet?

(2012) D. C. Javitt   SCHIZOPHRENIA BULLETIN

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

AKT/GSK3 signaling pathway and schizophrenia

(2012) Effat S. Emamian   Frontiers in Molecular Neuroscience

Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish

(2011) Eva Jolanda Münzel et al.   GLIA

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

(2011) Stacy Steinberg et al.   HUMAN MOLECULAR GENETICS

Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

(2011) Xiaoyang Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Regulation of NRG1 Isoform Expression by Neuronal Activity

(2011) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Neuregulin 1 Promotes Excitatory Synapse Development and Function in GABAergic Interneurons

(2011) A. K. Ting et al.   JOURNAL OF NEUROSCIENCE

Axonally Derived Neuregulin-1 Is Required for Remyelination and Regeneration after Nerve Injury in Adulthood

(2011) F. R. Fricker et al.   JOURNAL OF NEUROSCIENCE

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

BACE1 in central nervous system myelination revisited

(2011) H Treiber et al.   MOLECULAR PSYCHIATRY

A Src link in schizophrenia

(2011) Chang-Gyu Hahn   NATURE MEDICINE

Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

(2011) Graham M Pitcher et al.   NATURE MEDICINE

TACE (ADAM17) inhibits Schwann cell myelination

(2011) Rosa La Marca et al.   NATURE NEUROSCIENCE

Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia

(2011) Amy E. Geddes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment

(2011) H. Nasrallah et al.   Epidemiology and Psychiatric Sciences

Biological Validation of Increased Schizophrenia Risk With NRG1, ERBB4, and AKT1 Epistasis via Functional Neuroimaging in Healthy Controls

(2010) Kristin K. Nicodemus et al.   ARCHIVES OF GENERAL PSYCHIATRY

Neuregulin 1–erbB4 pathway in schizophrenia: From genes to an interactome

(2010) Anamika Banerjee et al.   BRAIN RESEARCH BULLETIN

Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility

(2010) N. V. L. Hayes et al.   ENDOCRINE-RELATED CANCER

Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells

(2010) April Kalinowski et al.   FASEB JOURNAL

Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice

(2010) Doo Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

(2010) Brian D. Hitt et al.   Molecular Neurodegeneration

Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition

(2010) B Morar et al.   MOLECULAR PSYCHIATRY

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

(2010) Pietro Fazzari et al.   NATURE

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1

(2010) Taisuke Kato et al.   PLoS One

Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

(2010) W.-T. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Myelin Brake: When Enough Is Enough

(2010) W. B. Macklin   Science Signaling

Amyloid-β42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis

(2009) Gaetano Vattemi et al.   ACTA NEUROPATHOLOGICA

Fine Mapping on Chromosome 10q22-q23 Implicates Neuregulin 3 in Schizophrenia

(2009) Pei-Lung Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage

(2009) Scot Libants et al.   BMC EVOLUTIONARY BIOLOGY

 1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth

(2009) C. S. Barros et al.   DEVELOPMENT

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

Common variants in polygenic schizophrenia

(2009) Joseph T Glessner et al.   GENOME BIOLOGY

Neuregulin 3 Genetic Variations and Susceptibility to Schizophrenia in a Chinese Population

(2008) Ying-Chieh Wang et al.   BIOLOGICAL PSYCHIATRY

System-wide Investigation of ErbB4 Reveals 19 Sites of Tyr Phosphorylation that Are Unusually Selective in Their Recruitment Properties

(2008) Alexis Kaushansky et al.   CHEMISTRY & BIOLOGY

Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17

(2008) Miriam Deuss et al.   Current Alzheimer Research

Early myoclonic encephalopathy caused by a disruption of the neuregulin-1 receptor ErbB4

(2008) Liesbeth Backx et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

The Neuregulin Family of Genes and their Multiple Splice Variants in Breast Cancer

(2008) Nandini V. L. Hayes et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

(2008) Bastian G. Brinkmann et al.   NEURON

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antipsychotic drug action: antagonism, inverse agonism or partial agonism

(2008) P STRANGE   TRENDS IN PHARMACOLOGICAL SCIENCES

Tissue engineering intrafusal fibers: Dose- and time-dependent differentiation of nuclear bag fibers in a defined in vitro system using neuregulin 1-β-1

(2007) John W. Rumsey et al.   BIOMATERIALS

BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease

(2007) Dione Kobayashi et al.   NEUROBIOLOGY OF AGING

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous ‘knockout’ of the schizophrenia risk gene neuregulin-1

(2007) Colm M.P. O'Tuathaigh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY