The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

(2014) Kathrin Töllner et al.   ANNALS OF NEUROLOGY

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

(2014) Frances-Rose Schumacher et al.   BIOCHEMICAL JOURNAL

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis

(2014) Ana Cristina Andérica-Romero et al.   CELLULAR SIGNALLING

Structural insights into regulatory mechanisms of MO25-mediated kinase activation

(2014) Qian Hao et al.   JOURNAL OF STRUCTURAL BIOLOGY

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain

(2014) Kristopher T. Kahle et al.   JAMA Neurology

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Structural insights into the activation of MST3 by MO25

(2013) Youcef Mehellou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms

(2013) Yutaro Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

(2013) Takayasu Mori et al.   BIOCHEMICAL JOURNAL

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Detection of mutations inKLHL3andCUL3in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)

(2013) Mark Glover et al.   CLINICAL SCIENCE

N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling

(2013) Zesergio Melo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC12 family of electroneutral cation-coupled chloride cotransporters

(2013) Juan Pablo Arroyo et al.   MOLECULAR ASPECTS OF MEDICINE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron

(2013) E. Vidal-Petiot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism

(2013) Zhubing Shi et al.   STRUCTURE

A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3

(2013) Shoji Tsuji et al.   BMC Nephrology

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)

(2013) Valérie Bercier et al.   PLoS Genetics

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels

(2012) Koichiro Susa et al.   Clinical and Experimental Nephrology

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

(2012) Sanaz Eftekhari et al.   EPILEPSIA

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway

(2012) Nils van der Lubbe et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells

(2012) Silvia Cruz-Rangel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Similar effects of all WNK3 variants on SLC12 cotransporters

(2011) Silvia Cruz-Rangel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

(2011) Jacob O. Thastrup et al.   BIOCHEMICAL JOURNAL

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

Two types of chloride transporters are required for GABAAreceptor-mediated inhibition inC. elegans

(2011) Andrew Bellemer et al.   EMBO JOURNAL

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Diuretics and epilepsy: Will the past and present meet?

(2011) Edward H. Maa et al.   EPILEPSIA

WNK1 Regulates Vasoconstriction and Blood Pressure Response to α 1 -Adrenergic Stimulation in Mice

(2011) Sonia Bergaya et al.   HYPERTENSION

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

(2011) M. Chiga et al.   JOURNAL OF CELL SCIENCE

Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue

(2011) Yijun Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Aldosterone Paradox: Differential Regulation of Ion Transport in Distal Nephron

(2011) Juan Pablo Arroyo et al.   PHYSIOLOGY

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

How GABA generates depolarization

(2010) Nicholas C. Spitzer   JOURNAL OF PHYSIOLOGY-LONDON

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

(2010) J. Hadchouel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Seizure Sensitivity Is Ameliorated by Targeted Expression of K+-Cl- Cotransporter Function in the Mushroom Body of the Drosophila Brain

(2009) D. S. Hekmat-Scafe et al.   GENETICS

The Potassium Chloride Cotransporter KCC-2 Coordinates Development of Inhibitory Neurotransmission and Synapse Structure in Caenorhabditis elegans

(2009) J. E. Tanis et al.   JOURNAL OF NEUROSCIENCE

A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans

(2009) Adebowale Adeyemo et al.   PLoS Genetics

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

(2008) Eric Delpire et al.   BIOCHEMICAL JOURNAL

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

(2008) Weizhen Ji et al.   NATURE GENETICS

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

(2008) Kristopher T. Kahle et al.   Neurosurgical Focus

Whole-genome association study identifies STK39 as a hypertension susceptibility gene

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology