The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

(2013) Takayasu Mori et al.   BIOCHEMICAL JOURNAL

N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling

(2013) Zesergio Melo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC12 family of electroneutral cation-coupled chloride cotransporters

(2013) Juan Pablo Arroyo et al.   MOLECULAR ASPECTS OF MEDICINE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

High-Frequency Variant p.T60M in NaCl Cotransporter and Blood Pressure Variability in Han Chinese

(2012) Leping Shao et al.   AMERICAN JOURNAL OF NEPHROLOGY

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells

(2012) Silvia Cruz-Rangel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport

(2012) Kenneth B. Gagnon et al.   PHYSIOLOGICAL REVIEWS

Similar effects of all WNK3 variants on SLC12 cotransporters

(2011) Silvia Cruz-Rangel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

(2011) Jacob O. Thastrup et al.   BIOCHEMICAL JOURNAL

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

(2011) M. Chiga et al.   JOURNAL OF CELL SCIENCE

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

(2011) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Diuretics and Salt Transport Along the Nephron

(2011) Paul L. Bernstein et al.   SEMINARS IN NEPHROLOGY

The activity of the thiazide-sensitive Na+–Cl– cotransporter is regulated by protein phosphatase PP4

(2010) Mark Glover et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Regulation of K–Cl cotransport in erythrocytes of frog Rana temporaria by commonly used protein kinase and protein phosphatase inhibitors

(2009) Gennadii Petrovich Gusev et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Structure of the OSR1 kinase, a hypertension drug target

(2008) Fabrizio Villa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Molecular Physiology of the WNK Kinases

(2007) Kristopher T. Kahle et al.   Annual Review of Physiology