Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

Knockout of Ste20-Like Proline/Alanine-Rich Kinase (SPAK) Attenuates Intestinal Inflammation in Mice

(2013) Yuchen Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

(2013) Longqin Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphorylation of Na–Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination

(2012) Muhammad Zakir Hossain Khan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WNK3-SPAK Interaction is Required for the Modulation of NCC and other Members of the SLC12 Family

(2012) Diana Pacheco-Alvarez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

(2012) Hidenori Nishida et al.   HYPERTENSION

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation

(2012) Tomas Garzon-Muvdi et al.   PLOS BIOLOGY

With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume

(2011) Brian R. Haas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immunolocalization of WNK4 in mouse kidney

(2011) Mayuko Ohno et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

(2011) M. Chiga et al.   JOURNAL OF CELL SCIENCE

Overexpression of Ste20-Related Proline/Alanine-Rich Kinase Exacerbates Experimental Colitis in Mice

(2011) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Acute Insulin Stimulation Induces Phosphorylation of the Na-Cl Cotransporter in Cultured Distal mpkDCT Cells and Mouse Kidney

(2011) Eisei Sohara et al.   PLoS One

Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney

(2010) Gulibaha Talati et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of WNK1 kinase by extracellular potassium

(2010) Shotaro Naito et al.   Clinical and Experimental Nephrology

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pathophysiological roles of WNK kinases in the kidney

(2010) Shinichi Uchida   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Excitation–contraction coupling in resistance mesenteric arteries: Evidence for NKCC1-mediated pathway

(2009) Svetlana V. Koltsova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

(2009) Akihito Ohta et al.   HUMAN MOLECULAR GENETICS

Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study

(2009) Jing Chen et al.   LANCET

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction

(2009) Ryan C. Clark et al.   NATURAL PRODUCT REPORTS

WNK Kinases and Renal Sodium Transport in Health and Disease

(2008) James A. McCormick et al.   HYPERTENSION

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

(2008) Motoko Chiga et al.   KIDNEY INTERNATIONAL

A novel protein kinase signaling pathway essential for blood pressure regulation in humans

(2008) Kristopher T. Kahle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM