Functional synergy between the Munc13 C-terminal C1 and C2 domains

The Synaptic Vesicle Release Machinery

(2015) Josep Rizo et al.   Annual Review of Biophysics

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sec17 can trigger fusion oftrans-SNARE paired membranes without Sec18

(2015) Michael Zick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles

(2015) Taulant Bacaj et al.   PLOS BIOLOGY

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

A distinct tethering step is vital for vacuole membrane fusion

(2014) Michael Zick et al.   eLife

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

(2014) Ying Lai et al.   eLife

Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex

(2013) Junjie Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

SNAREpin Assembly by Munc18-1 Requires Previous Vesicle Docking by Synaptotagmin 1

(2012) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

(2012) Jiajie Diao et al.   eLife

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

(2011) Wei Li et al.   STRUCTURE

Tethering Factors as Organizers of Intracellular Vesicular Traffic

(2010) I-Mei Yu et al.   Annual Review of Cell and Developmental Biology

HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion

(2010) Hao Xu et al.   EMBO JOURNAL

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

(2010) H. K. Lee et al.   SCIENCE

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotides

(2009) Y.-H. M. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Binding of the Munc13-1 MUN Domain to Membrane-Anchored SNARE Complexes†

(2008) Rong Guan et al.   BIOCHEMISTRY

The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function

(2008) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY