Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Synip Arrests SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding Inhibitor

(2013) Haijia Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending–dependent manner

(2013) Haijia Yu et al.   MOLECULAR BIOLOGY OF THE CELL

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

(2012) Marieke Meijer et al.   EMBO JOURNAL

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

(2012) M. P. Christie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Resolving the Function of Distinct Munc18-1/SNARE Protein Interaction Modes in a Reconstituted Membrane Fusion Assay

(2011) Yvette Schollmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

(2011) Jenna L. Jewell et al.   JOURNAL OF CELL BIOLOGY

Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex

(2011) Lei Shi et al.   MOLECULAR BIOLOGY OF THE CELL

HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites

(2011) Lukas Krämer et al.   MOLECULAR BIOLOGY OF THE CELL

Topological arrangement of the intracellular membrane fusion machinery

(2011) Shailendra S. Rathore et al.   MOLECULAR BIOLOGY OF THE CELL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

(2011) Shyam S Krishnakumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Bridging and Hemifusion by Denaturated Munc18

(2011) Yi Xu et al.   PLoS One

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

(2011) P. Burkhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping Insulin/GLUT4 Circuitry

(2011) Alexander F. Rowland et al.   TRAFFIC

Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion

(2010) Jiajie Diao et al.   ACS Chemical Neuroscience

Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2

(2010) M. Meeths et al.   BLOOD

At the junction of SNARE and SM protein function

(2010) Chavela M Carr et al.   CURRENT OPINION IN CELL BIOLOGY

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion

(2010) Jingshi Shen et al.   JOURNAL OF CELL BIOLOGY

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

(2010) V. Cetica et al.   JOURNAL OF MEDICAL GENETICS

The SM protein Vps33 and the t-SNARE Habc domain promote fusion pore opening

(2010) Michel Pieren et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

(2010) S. S. Rathore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functions of Munc18-1 in Regulated Exocytosis

(2009) Robert D. Burgoyne et al.   Annals of the New York Academy of Sciences

Characterization of two distinct binding modes between syntaxin 4 and Munc18c

(2009) Veronica Aran et al.   BIOCHEMICAL JOURNAL

Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release

(2009) E. Oh et al.   DIABETES

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

(2009) Ferenc Deák et al.   JOURNAL OF CELL BIOLOGY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p

(2009) M. L. M. Furgason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils

(2008) Cristiana Brochetta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

Munc18a Scaffolds SNARE Assembly to Promote Membrane Fusion

(2008) Travis L. Rodkey et al.   MOLECULAR BIOLOGY OF THE CELL

De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy

(2008) Hirotomo Saitsu et al.   NATURE GENETICS

Membrane fusion

(2008) William Wickner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Negative Regulation of Syntaxin4/SNAP-23/VAMP2-Mediated Membrane Fusion by Munc18c In Vitro

(2008) Fiona M. Brandie et al.   PLoS One

SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes

(2008) D. Tareste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE

Munc18-1 Is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells

(2007) Lakshmanan Arunachalam et al.   MOLECULAR BIOLOGY OF THE CELL