Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular dynamics simulations

(2016) Siddharth S. Kesharwani et al.   JOURNAL OF MOLECULAR RECOGNITION

Stage-dependent ethoxyresorufin-O-deethylase (EROD) in vivo activity in medaka (Oryzias latipes) embryos

(2015) Miguel González-Doncel et al.   CHEMOSPHERE

Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver

(2015) KS Burgess et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio)

(2015) Jennifer Bräunig et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions

(2015) Ji Won Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal integration by the CYP1A1 promoter -- a quantitative study

(2015) P. Schulthess et al.   NUCLEIC ACIDS RESEARCH

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression

(2015) Seung Heon Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of the Gly45Asp variant of human cytochrome P450 1A1 using recombinant expression

(2015) Seung Heon Lee et al.   TOXICOLOGY LETTERS

PathVisio 3: An Extendable Pathway Analysis Toolbox

(2015) Martina Kutmon et al.   PLoS Computational Biology

Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs

(2015) D. P. Jackson et al.   Toxicology Research

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

(2015) Han-Jin Park et al.   PLoS One

TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398

(2014) Nozomi Fujisawa et al.   ARCHIVES OF TOXICOLOGY

Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum

(2014) Ji Won Park et al.   BIOCHEMICAL JOURNAL

Inhibitors and Prodrugs Targeting CYP1: A Novel Approach in Cancer Prevention and Therapy

(2014) Jiahua Cui et al.   CURRENT MEDICINAL CHEMISTRY

Epigenetic Determinants of CYP1A1 Induction by the Aryl Hydrocarbon Receptor Agonist 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)

(2014) Sabine Vorrink et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo

(2014) Jian Yin et al.   Journal of Zhejiang University-SCIENCE B

The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China

(2014) Jin-Guo Zou et al.   Lipids in Health and Disease

Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression

(2014) Sebastian Vaas et al.   TOXICOLOGY

The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90

(2014) Noriko Tsuji et al.   FEBS Open Bio

The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions

(2013) Karl Walter Bock   BIOLOGICAL CHEMISTRY

Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences

(2013) Goran Bozinovic et al.   BMC GENOMICS

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

(2013) Agnes A. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

(2013) Jiawang Liu et al.   MOLECULES

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?

(2013) S. L. Kelly et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459

(2013) Damir Simic et al.   TOXICOLOGY

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

(2013) Sabine U. Vorrink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TCDD dysregulation of 13 AHR-target genes in rat liver

(2013) John D. Watson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1

(2013) Issa E.A. Amara et al.   TOXICOLOGY LETTERS

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

(2012) Manish B. Shah et al.   BIOCHEMISTRY

What is the Functional Role of N-terminal Transmembrane Helices in the Metabolism Mediated by Liver Microsomal Cytochrome P450 and its Reductase?

(2012) Daniel Andrew Gideon et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Summary of Information on the Effects of Ionizing and Non-ionizing Radiation on Cytochrome P450 and Other Drug Metabolizing Enzymes and Transporters

(2012) Slobodan Rendic et al.   CURRENT DRUG METABOLISM

CYP1A1 is a target of miR-892a-mediated post-transcriptional repression

(2012) Seunghee Bae   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of cytochrome P4501A activity inhibition in three- to five-ringed polycyclic aromatic hydrocarbons embryotoxicity of marine medaka (Oryzias melastigma)

(2012) Jing-li Mu et al.   MARINE POLLUTION BULLETIN

Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression

(2012) Narendra P. Singh et al.   PLoS One

Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega−3 polyunsaturated fatty acids

(2012) Larry N. Agbor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes

(2012) Kikuko Araki et al.   TOXICOLOGY LETTERS

All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells

(2011) Marumi Ohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Cytochrome P450 1A1 Is a Novel Target Gene of Liver X Receptor α

(2011) Norihito Shibahara et al.   Drug Metabolism and Pharmacokinetics

Antigenotoxic activity of naturally occurring furanocoumarins

(2011) Shinsuke Marumoto et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung

(2011) Xavier Tekpli et al.   INTERNATIONAL JOURNAL OF CANCER

Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes

(2011) Joanna Edyta Fraczek et al.   INVESTIGATIONAL NEW DRUGS

Coordinate Regulation of Cytochrome P450 1A1 Expression in Mouse Liver by the Aryl Hydrocarbon Receptor and the β-Catenin Pathway

(2011) Albert Braeuning et al.   TOXICOLOGICAL SCIENCES

Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol

(2011) Mohamed A.M. El Gendy et al.   TOXICOLOGY LETTERS

Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)

(2010) Jens C. Otte et al.   AQUATIC TOXICOLOGY

Role of Epigenetic Mechanisms in Differential Regulation of the Dioxin-Inducible Human CYP1A1 and CYP1B1 Genes

(2010) S. R. Beedanagari et al.   MOLECULAR PHARMACOLOGY

Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines

(2010) Sudheer R. Beedanagari et al.   TOXICOLOGY LETTERS

Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

(2009) Kouichi Yoshinari et al.   BIOCHEMICAL PHARMACOLOGY

CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients

(2009) Martin D Jarvis et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

(2009) Anwar Anwar-Mohamed et al.   Expert Opinion on Drug Metabolism & Toxicology

Analysis of humanCYP1A1andCYP1A2genes and their shared bidirectional promoter in eight world populations

(2009) Lucia F. Jorge-Nebert et al.   HUMAN MUTATION

The Active Form of Human Aryl Hydrocarbon Receptor (AHR) Repressor Lacks Exon 8, and Its Pro185 and Ala185 Variants Repress both AHR and Hypoxia-Inducible Factor

(2009) S. I. Karchner et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of the morpholino gene knockdown technique in Fundulus heteroclitus: A tool for studying molecular mechanisms in an established environmental model

(2008) C MATSON et al.   AQUATIC TOXICOLOGY

Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster

(2008) Manabu Nukaya et al.   BIOCHEMICAL PHARMACOLOGY

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

(2008) Radim Vrzal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish

(2008) Cole W. Matson et al.   CHEMOSPHERE

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA