Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs

The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation

(2014) Laurie Prigent et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Krüppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene

(2014) Lucas Daniel Trucco et al.   FASEB JOURNAL

Functional Analysis of the Dioxin Response Elements (DREs) of the Murine CYP1A1 Gene Promoter: Beyond the Core DRE Sequence

(2014) Shuaizhang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aryl Hydrocarbon Receptor Repressor and TiPARP (ARTD14) Use Similar, but also Distinct Mechanisms to Repress Aryl Hydrocarbon Receptor Signaling

(2014) Laura MacPherson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3-Methylcholanthrene, an AhR Agonist, Caused Cell-Cycle Arrest by Histone Deacetylation through a RhoA-Dependent Recruitment of HDAC1 and pRb2 to E2F1 Complex

(2014) Chih-Cheng Chang et al.   PLoS One

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

(2014) Margaret M. Lowe et al.   PLoS One

Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors

(2014) Gregory D. Kennedy et al.   TOXICOLOGICAL SCIENCES

The Ah Receptor Recruits IKKα to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation

(2014) Hisaka Kurita et al.   TOXICOLOGICAL SCIENCES

The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2013) Liping Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis

(2013) Nuria Palau et al.   BMC GENOMICS

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

(2013) R. A. Budinsky et al.   CRITICAL REVIEWS IN TOXICOLOGY

Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response

(2013) Christoph F. A. Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide RNAi High-Throughput Screen Identifies Proteins Necessary for the AHR-Dependent Induction of CYP1A1 by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

(2013) Parrisa Solaimani et al.   TOXICOLOGICAL SCIENCES

A Single Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disrupts the Adult Uterine Response to Estradiol in Mice

(2013) Katherine A. Burns et al.   TOXICOLOGICAL SCIENCES

Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells

(2013) Dagmar Faust et al.   TOXICOLOGY LETTERS

2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway

(2013) Guangfei Xu et al.   TOXICOLOGY LETTERS

Ablation of sarcolipin results in atrial remodeling

(2012) Lai-Hua Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region

(2012) Neal A. Englert et al.   BIOCHEMICAL PHARMACOLOGY

Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo- p -dioxin-stimulated breast cancer cells proliferation

(2012) Yun-Ju Chen et al.   CANCER LETTERS

Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

(2012) Diana Vetter et al.   HEPATOLOGY

Ligand-dependent Corepressor (LCoR) Recruitment by Krüppel-like Factor 6 (KLF6) Regulates Expression of the Cyclin-dependent Kinase InhibitorCDKN1AGene

(2012) Mario R. Calderon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation

(2012) Laura MacPherson et al.   NUCLEIC ACIDS RESEARCH

GSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21

(2012) U E Lang et al.   ONCOGENE

High-Resolution Genome-wide Mapping of AHR and ARNT Binding Sites by ChIP-Seq

(2012) Raymond Lo et al.   TOXICOLOGICAL SCIENCES

Ah receptor- and Nrf2-gene battery members: Modulators of quinone-mediated oxidative and endoplasmic reticulum stress

(2011) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—Persistent pollutants affect programmed cell death

(2011) Martin Chopra et al.   CRITICAL REVIEWS IN TOXICOLOGY

Carcinogen-induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation

(2011) Mirko Tarocchi et al.   HEPATOLOGY

HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders

(2011) Hamid R. Rezvani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect

(2011) Gaku Tsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer

(2011) P-H Chen et al.   ONCOGENE

Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin

(2011) Jerald L. Ovesen et al.   TOXICOLOGICAL SCIENCES

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2011) Raymond Lo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth

(2010) C. Dietrich et al.   CARCINOGENESIS

The aryl hydrocarbon receptor: fine-tuning the immune-response

(2010) Marc Veldhoen et al.   CURRENT OPINION IN IMMUNOLOGY

Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance

(2010) Jere Lindén et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Biology of Krüppel-like factor 6 transcriptional regulator in cell life and death

(2010) Verónica Andreoli et al.   IUBMB LIFE

Mechanistic Insights into the Events That Lead to Synergistic Induction of Interleukin 6 Transcription upon Activation of the Aryl Hydrocarbon Receptor and Inflammatory Signaling

(2010) Brett C. DiNatale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Epigenetic Mechanisms in Differential Regulation of the Dioxin-Inducible Human CYP1A1 and CYP1B1 Genes

(2010) S. R. Beedanagari et al.   MOLECULAR PHARMACOLOGY

Nucleo-Cytoplasmic Localization Domains Regulate Krüppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function

(2010) Estefanía Rodríguez et al.   PLoS One

3-Methylcholanthrene Induces Differential Recruitment of Aryl Hydrocarbon Receptor to Human Promoters

(2010) Andrea Pansoy et al.   TOXICOLOGICAL SCIENCES

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia

(2010) Kristen A. Mitchell et al.   TOXICOLOGY

High-throughput evaluation of aryl hydrocarbon receptor-binding sites selected via chromatin immunoprecipitation-based screening in Hepa-1c1c7 cells stimulated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2009) Masaki Kinehara et al.   GENES & GENETIC SYSTEMS

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

(2009) Emily A. Stevens et al.   IMMUNOLOGY

An Overview of the Effects of Dioxins and Dioxin-Like Compounds on Vertebrates, as Documented in Human and Ecological Epidemiology

(2009) SALLY S. WHITE et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

(2009) O Sorg et al.   LANCET

KLF6 inhibits estrogen receptor-mediated cell growth in breast cancer via a c-Src-mediated pathway

(2009) Jun Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Aryl Hydrocarbon Receptor Regulates Cell Cycle Progression in Human Breast Cancer Cells via a Functional Interaction with Cyclin-Dependent Kinase 4

(2009) M. A. Barhoover et al.   MOLECULAR PHARMACOLOGY

ARNT PAS-B has a fragile native state structure with an alternative β-sheet register nearby in sequence space

(2009) Matthew R. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice

(2009) Paul C. Boutros et al.   TOXICOLOGICAL SCIENCES

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

TGF-β regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3–Sp1–KLF6 interaction

(2008) Luisa M. Botella et al.   BIOCHEMICAL JOURNAL

Timing is everything: Consequences of transient and sustained AhR activity

(2008) Kristen A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions

(2008) Fumiaki Ohtake et al.   BIOCHEMICAL PHARMACOLOGY

Inflammatory Signaling and Aryl Hydrocarbon Receptor Mediate Synergistic Induction of Interleukin 6 in MCF-7 Cells

(2008) B. D. Hollingshead et al.   CANCER RESEARCH

Silencing of the transcription factor KLF6 by siRNA leads to cell cycle arrest and sensitizes cells to apoptosis induced by DNA damage

(2008) D S D'Astolfo et al.   CELL DEATH AND DIFFERENTIATION

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer

(2008) Mark Hartel et al.   EUROPEAN JOURNAL OF CANCER

Functional role of the KLF6 tumour suppressor gene in gastric cancer

(2008) Jaya Sangodkar et al.   EUROPEAN JOURNAL OF CANCER

Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor

(2008) Anatoly Soshilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of CREB1 and Histone Deacetylase 2 (HDAC2) to the Mouse Ltbp-1 Promoter Regulates its Constitutive Expression in a Dioxin Receptor-dependent Manner

(2008) Aurea Gomez-Duran et al.   JOURNAL OF MOLECULAR BIOLOGY

Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells

(2008) Robert T. Taylor et al.   TOXICOLOGICAL SCIENCES

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY