Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism – an in vitro study

(2014) Jacek Wójcikowski et al.   Pharmacological Reports

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

(2013) Agnes A. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyranoflavones: A Group of Small-Molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1

(2013) Jiawang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: Selectivity, kinetic characterization, and molecular modeling

(2013) Sheng-Nan Lo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro inhibitory effect of luotonin A on human CYP1A

(2012) Yurngdong Jahng et al.   ARCHIVES OF PHARMACAL RESEARCH

Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1

(2012) Renata Mikstacka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2

(2012) Jiawang Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Contributions of Human Enzymes in Carcinogen Metabolism

(2012) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test

(2012) S. Olguín-Reyes et al.   FOOD AND CHEMICAL TOXICOLOGY

Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles

(2012) Charlotte M. Miller et al.   RSC Advances

Effect of CYP1A1 MSPI Polymorphism on the Relationship Between TP53 Mutation and CDKN2A Hypermethylation in Non-small Cell Lung Cancer

(2011) Cong Tan et al.   ARCHIVES OF MEDICAL RESEARCH

Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones

(2011) Jayalakshmi Sridhar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer

(2011) Jing-Jun Wang et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line

(2011) Rong Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes

(2010) Satoshi Yamaori et al.   BIOCHEMICAL PHARMACOLOGY

Selective inhibition of methoxyflavonoids on human CYP1B1 activity

(2010) Hitomi Takemura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure−Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives

(2010) Tsutomu Shimada et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytochrome P450 1B1 Contributes to Angiotensin II–Induced Hypertension and Associated Pathophysiology

(2010) Brett L. Jennings et al.   HYPERTENSION

Structural Characterization of the Complex between α-Naphthoflavone and Human Cytochrome P450 1B1

(2010) An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

(2009) Vasilis P Androutsopoulos et al.   BMC CANCER

Reverse Type I Binding Spectra of Human Cytochrome P450 1B1 Induced by Flavonoid, Stilbene, Pyrene, Naphthalene, Phenanthrene, and Biphenyl Derivatives That Inhibit Catalytic Activity: A Structure−Function Relationship Study

(2009) Tsutomu Shimada et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Insights into the Structure, Function, and Regulation of Human Cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   CURRENT DRUG METABOLISM

Further Assessment of 17 -Ethinyl Estradiol as an Inhibitor of Different Human Cytochrome P450 Forms in Vitro

(2009) S.-Y. Chang et al.   DRUG METABOLISM AND DISPOSITION

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin

(2009) Thomas K. H. Chang et al.   JOURNAL OF PINEAL RESEARCH

A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes

(2009) Aaron T. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene

(2009) Young-Jin Chun et al.   TOXICOLOGY LETTERS

Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity

(2008) Tsutomu Shimada et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes

(2008) F. Qiu et al.   DRUG METABOLISM AND DISPOSITION

Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo

(2008) Marjo J. Karjalainen et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

(2007) Paul F. Hollenberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY