Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level

Prevention of ochratoxin A contamination of foodand ochratoxin A detoxification by microorganisms – a review

(2018) P. Cicoňová et al.   CZECH JOURNAL OF FOOD SCIENCES

In vitro and in vivo metabolism of ochratoxin A: a comparative study using ultra-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry

(2015) Shupeng Yang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

(2015) L.N. Cariddi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Bottled water: Analysis of mycotoxins by LC–MS/MS

(2015) A.T. Mata et al.   FOOD CHEMISTRY

Thermal stability and kinetics of degradation of deoxynivalenol, deoxynivalenol conjugates and ochratoxin A during baking of wheat bakery products

(2015) Arnau Vidal et al.   FOOD CHEMISTRY

Presence of mycotoxins in animal milk: A review

(2015) Myra Evelyn Flores-Flores et al.   FOOD CONTROL

Mycotoxins in Plant-Based Dietary Supplements: Hidden Health Risk for Consumers

(2015) Zdenka Veprikova et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Food Coloring Agents and Plant Food Supplements Derived from Vitis vinifera: A New Source of Human Exposure to Ochratoxin A

(2015) Michele Solfrizzo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ochratoxin A induces DNA damage and G2 phase arrest in human esophageal epithelium Het-1A cells in vitro

(2015) Jing Liu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Role of p53 in the Progression from Ochratoxin A-Induced DNA Damage to Gene Mutations in the Kidneys of Mice

(2015) Ken Kuroda et al.   TOXICOLOGICAL SCIENCES

Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity

(2015) Rui Liang et al.   Scientific Reports

Mycobiota and Mycotoxins in Traditional Medicinal Seeds from China

(2015) Amanda Chen et al.   Toxins

Nation-Based Occurrence and Endogenous Biological Reduction of Mycotoxins in Medicinal Herbs and Spices

(2015) Kee Do et al.   Toxins

Contribution of Organ Vasculature in Rat Renal Analysis for Ochratoxin A: Relevance to Toxicology of Nephrotoxins

(2015) Peter Mantle et al.   Toxins

Comparative Ochratoxin Toxicity: A Review of the Available Data

(2015) Alexandra Heussner et al.   Toxins

Selenium Alleviates Porcine Nephrotoxicity of Ochratoxin A by Improving Selenoenzyme Expression In Vitro

(2015) Fang Gan et al.   PLoS One

Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells

(2014) Zeynep Özcan et al.   ARCHIVES OF TOXICOLOGY

The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats

(2014) Marie Stiborová et al.   ARCHIVES OF TOXICOLOGY

Assessment and characterisation of yeast-based products intended to mitigate ochratoxin exposure usingin vitroandin vivomodels

(2014) A. Pfohl-Leszkowicz et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by ochratoxin A in human embryonic kidney cells (HEK-293)

(2014) Qian Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Evaluation of the transfer rate of ochratoxin a to decoctions of herbal medicines

(2014) Won-Bo Shim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Presence of Ochratoxin A (OTA) Mycotoxin in Alcoholic Drinks from Southern European Countries: Wine and Beer

(2014) Julia Bellver Soto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

(2014) Miklós Poór et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

DNA damage and S phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK 293)

(2014) Qian Yang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Evaluating Weight of Evidence in the Mystery of Balkan Endemic Nephropathy

(2014) Travis Bui-Klimke et al.   RISK ANALYSIS

Ochratoxin A induces rat renal carcinogenicity with limited induction of oxidative stress responses

(2014) Xiaozhe Qi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Further Aspects of Ochratoxin A-Cation Interactions: Complex Formation with Zinc Ions and a Novel Analytical Application of Ochratoxin A-Magnesium Interaction in the HPLC-FLD System

(2014) Miklós Poór et al.   Toxins

A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

(2014) Alice Limonciel et al.   Toxins

Is Increased Susceptibility to Balkan Endemic Nephropathy in Carriers of Common GSTA1 (*A/*B) Polymorphism Linked with the Catalytic Role of GSTA1 in Ochratoxin A Biotransformation? Serbian Case Control Study and In Silico Analysis

(2014) Zorica Reljic et al.   Toxins

Transfer of Ochratoxin A into Tea and Coffee Beverages

(2014) Frantisek Malir et al.   Toxins

Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro

(2013) Jinfeng Cui et al.   ARCHIVES OF TOXICOLOGY

Exposure of infants to ochratoxin A with breast milk

(2013) K. Muñoz et al.   ARCHIVES OF TOXICOLOGY

Glutathione Conjugates of Ochratoxin a as Biomarkers of Exposure / Glutationski Konjugati Okratoksina A Kao Biomarkeri Izloženosti

(2013) Mariana Tozlovanu et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells — up regulation of Nrf2 expression and down regulation of NF-κB and COX-2

(2013) Periasamy Ramyaa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

In vitroandin vivoprotective effects of three mycotoxin adsorbents against ochratoxin A in broiler chickens

(2013) J.N. Trailović et al.   BRITISH POULTRY SCIENCE

Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats

(2013) S. Sezin Palabiyik et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A review on ochratoxin A transcriptomic studies

(2013) Ariane Vettorazzi et al.   FOOD AND CHEMICAL TOXICOLOGY

Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin – Modulation by Nrf2

(2013) Periasamy Ramyaa et al.   FOOD AND CHEMICAL TOXICOLOGY

Quantitation of species differences in albumin–ligand interactions for bovine, human and rat serum albumins using fluorescence spectroscopy: A test case with some Sudlow's site I ligands

(2013) Miklós Poór et al.   JOURNAL OF LUMINESCENCE

Thermodynamic study of the effects of ethanol on the interaction of ochratoxin A with human serum albumin

(2013) Yin Li et al.   JOURNAL OF LUMINESCENCE

Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A

(2013) Juanjuan Zheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ochratoxin A induces karyomegaly and cell cycle aberrations in renal tubular cells without relation to induction of oxidative stress responses in rats

(2013) Eriko Taniai et al.   TOXICOLOGY LETTERS

The carotenoid lycopene protects rats against DNA damage induced by Ochratoxin A

(2013) Sevtap Aydin et al.   TOXICON

Producers and Important Dietary Sources of Ochratoxin A and Citrinin

(2013) Vladimir Ostry et al.   Toxins

Toxicity of Ochratoxin A and Its Modulation by Antioxidants: A Review

(2013) Valeria Sorrenti et al.   Toxins

Flavonoid aglycones can compete with Ochratoxin A for human serum albumin: A new possible mode of action

(2012) Miklós Poór et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Interaction of alkali and alkaline earth ions with Ochratoxin A

(2012) Miklós Poór et al.   JOURNAL OF LUMINESCENCE

Fluorescence spectroscopic investigation of competitive interactions between ochratoxin A and 13 drug molecules for binding to human serum albumin

(2012) Miklós Poór et al.   LUMINESCENCE

Ochratoxin A and Mitotic Disruption: Mode of Action Analysis of Renal Tumor Formation by Ochratoxin A

(2012) Angela Mally   TOXICOLOGICAL SCIENCES

Ochratoxin A induces oxidative DNA damage and G1 phase arrest in human peripheral blood mononuclear cells in vitro

(2012) Jing Liu et al.   TOXICOLOGY LETTERS

Dimethylarginine Dimethylaminohydrolase/Nitric Oxide Synthase Pathway in Liver and Kidney: Protective Effect of Cyanidin 3-O-β-D-Glucoside on Ochratoxin-A Toxicity

(2012) Valeria Sorrenti et al.   Toxins

Apoptosis Induction by OTA and TNF-α in Cultured Primary Rat Hepatocytes and Prevention by Silibinin

(2012) Ebtisam Essid et al.   Toxins

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)

(2011) Chi Chun Wong et al.   BIOCHEMICAL PHARMACOLOGY

Structure–Activity Relationships Imply Different Mechanisms of Action for Ochratoxin A-Mediated Cytotoxicity and Genotoxicity

(2011) Kheira Hadjeba-Medjdoub et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An Update on Direct Genotoxicity as a Molecular Mechanism of Ochratoxin A Carcinogenicity

(2011) Annie Pfohl-Leszkowicz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Perturbation of Mitosis through Inhibition of Histone Acetyltransferases: The Key to Ochratoxin A Toxicity and Carcinogenicity?

(2011) Kristin Czakai et al.   TOXICOLOGICAL SCIENCES

ERK and p38 MAPK signaling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells

(2011) Yuan Wang et al.   TOXICOLOGY LETTERS

Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours

(2010) Annie Pfohl-Leszkowicz   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Ameliorative effect of emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice

(2010) Devjani Chakraborty et al.   International Journal of Occupational Medicine and Environmental Health

Ochratoxin A induces G2 phase arrest in human gastric epithelium GES-1 cells in vitro

(2010) Jinfeng Cui et al.   TOXICOLOGY LETTERS

Molecular Mechanism of Ochratoxin A Transport in the Kidney

(2010) Naohiko Anzai et al.   Toxins

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

(2010) Stoycho D. Stoev   Toxins

Ochratoxin A: General Overview and Actual Molecular Status

(2010) André El Khoury et al.   Toxins

Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity

(2009) Melanie Adler et al.   CARCINOGENESIS

Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment

(2009) Peter G. Mantle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ochratoxin A non-conventional exposure sources — A review

(2009) S.C. Duarte et al.   MICROCHEMICAL JOURNAL

Formation of 2′-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA

(2009) Annie Pfohl-Leszkowicz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ochratoxin A–Mediated DNA and Protein Damage: Roles of Nitrosative and Oxidative Stresses

(2009) Christophe Cavin et al.   TOXICOLOGICAL SCIENCES

Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex

(2009) Vilim Žlender et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity

(2009) G. Ranaldi et al.   TOXICOLOGY IN VITRO

Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   FOOD AND CHEMICAL TOXICOLOGY

Ochratoxin A decontamination: A review

(2008) Susana Amézqueta et al.   FOOD CONTROL

Identification and in Vitro Cytotoxicity of Ochratoxin A Degradation Products Formed during Coffee Roasting

(2008) Benedikt Cramer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Absence of 2′-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS

(2008) Thierry Delatour et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mycotoxins and the kidney: Modes of action for renal tumor formation by ochratoxin A in rodents

(2008) Angela Mally et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inula crithmoides extract protects against ochratoxin A-induced oxidative stress, clastogenic and mutagenic alterations in male rats

(2008) Mosaad A. Abdel-Wahhab et al.   TOXICON

Bioactivation and DNA adduction as a rationale for ochratoxin A carcinogenesis

(2008) R. Manderville et al.   World Mycotoxin Journal

Levels of ochratoxin A in serum from urban and rural Portuguese populations and estimation of exposure degree

(2007) C.M. Lino et al.   FOOD AND CHEMICAL TOXICOLOGY