Article
Pharmacology & Pharmacy
Hemant Giri, Amit K. Srivastava, Ulhas P. Naik
Summary: This study aimed to determine the role of ASK1 in thrombin-induced endothelial permeability. The results showed that the lack of ASK1 attenuated thrombin-induced vascular permeability in vivo. In addition, the presence of ASK1 inhibitor reduced thrombin-induced endothelial permeability and gap formation, and restored the normal location of proteins at the junctions.
VASCULAR PHARMACOLOGY
(2022)
Article
Toxicology
Jiabin Chen, Weina Lai, Yaotang Deng, Min Liu, Ming Dong, Zhidong Liu, Ting Wang, Xiang Li, Zhiqiang Zhao, Xiao Yin, Jinmei Yang, Rian Yu, Lili Liu
Summary: This study investigated the role of miR-363-3p in Cd-induced nephrotoxicity in occupational workers. The findings suggest that the increase of miR-363-3p is associated with down-regulation of PI3K and suppressed proliferation and enhanced apoptosis of renal tubule epithelial cells. MiR-363-3p may be considered for possible therapeutic strategies for Cd-associated kidney damage.
TOXICOLOGY LETTERS
(2021)
Article
Medicine, Research & Experimental
Feby Savira, Andrew R. Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M. Jucker, Robert N. Willette, Darren J. Kelly, Bing H. Wang
Summary: The study showed that Indoxyl sulfate (IS) impairs endothelium-dependent vasorelaxation and endothelial cell migration, while inhibition of apoptosis signal regulating kinase 1 (ASK1) can alleviate these effects and promote autocrine interleukin 8 (IL-8) pro-angiogenic signaling.
Article
Environmental Sciences
Xingde Du, Haohao Liu, Xiaohui Liu, Xinghai Chen, Le Yuan, Ya Ma, Hui Huang, Yueqin Wang, Rui Wang, Shiyu Zhang, Zhihui Tian, Linjia Shi, Huizhen Zhang
Summary: The research has revealed the significant role of ASK1 in MC-LR-induced ovarian injury and apoptosis. Inhibiting ASK1 expression effectively alleviated MC-LR-induced ovarian cell damage, providing new insights for preventing female reproductive toxicity induced by MCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Dan Tang, Wei Xiao, Wen-Ting Gu, Zhi-Tong Zhang, Shu-Hong Xu, Zhi-Quan Chen, You-Hua Xu, Lu-Yong Zhang, Shu-Mei Wang, Hong Nie
Summary: This study demonstrates that PTS can protect against MGO-induced endothelial cell cytotoxicity by regulating glyoxalase, oxidative stress, and apoptosis. PTS enhances GLO-1 levels and GSH content to activate the glyoxalase system, eliminates toxic MGO and AGEs, suppresses oxidative stress through Nrf2 activation, and alleviates apoptosis in HUVECs by inhibiting mitochondrial-dependent signaling cascades. These findings suggest that PTS may be beneficial in the treatment of diabetic vascular complications.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Alexandra H. Mandarano, Tarsha L. Harris, Blaine M. Creasy, Marie Wehenkel, Marygrace Duggar, Benjamin A. Wilander, Ashutosh Mishra, Jeremy Chase Crawford, Sarah A. Mullen, Katherine M. Williams, Meenu Pillai, Anthony A. High, Maureen A. McGargill
Summary: Drak2-deficient mice are resistant to autoimmune diseases and effectively eliminate pathogens and tumors. The absence of Drak2 in T cells leads to resistance to type 1 diabetes (T1D) in non-obese diabetic (NOD) mice, which requires the presence of regulatory T cells (Tregs). Drak2 regulates IL-2 signaling by inhibiting STAT5A phosphorylation, and its absence enhances thymic Treg development.
Article
Pharmacology & Pharmacy
Lina Wang, Liyu Su, Yuyan Cen, Jiao Li, Jianmin Yang, Yan Li
Summary: In this study, it was found that the expression of miRNA-nov-1 increased in N27 cells exposed to manganese and overexpression of miRNA-nov-1 promoted apoptosis in these cells. Further investigations revealed a negative regulatory relationship between miRNA-nov-1 and Dhrs3. Overexpression of miRNA-nov-1 reduced the protein level of Dhrs3, increased caspase-3 protein expression, activated the mTOR signaling pathway, and enhanced cell apoptosis in manganese-exposed N27 cells. Conversely, low expression of miRNA-nov-1 decreased Caspase-3 protein expression, suppressed the mTOR signaling pathway, and reduced cell apoptosis. However, these effects were reversed by knockdown of Dhrs3.
Article
Pharmacology & Pharmacy
Liye Zhu, Haomiao Wang, Jieyu Yuhan, Boyang Zhang, Hongyu Li, Charles Asakiya, Kunlun Huang, Xiaoyun He, Wentao Xu
Summary: The study found that HEK293 cell-derived exosomes treated with OTA could induce cytotoxicity by increasing ROS levels and decreasing mitochondrial membrane potential, mainly affecting protein metabolism and cell cycle. Furthermore, exosomes extracted by ultracentrifugation were more suitable for experimental use.
Article
Biochemistry & Molecular Biology
Ji Hun Lee, Sang Hee Ji, Jong Seung Lim, Sunjoo Ahn, Hwi-Yeol Yun, Seong Hwan Kim, Jin Sook Song
Summary: This study investigated the anti-neuroinflammatory effects and brain pharmacokinetic properties of selonsertib. Results showed that selonsertib inhibited inflammatory cytokines and NO production by suppressing ASK1 phosphorylation, and attenuated TNF-alpha levels in a murine neuroinflammation model. Pharmacokinetic studies revealed that selonsertib was rapidly absorbed into the systemic circulation, but had limited brain distribution.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anni Jiang, Jing Liu, Yumei Wang, Chun Zhang
Summary: This study reveals that the cGAS-STING-IRF3-PFKFB3 signaling pathway plays a role in promoting renal fibrosis under hypoxia conditions, with a close relationship to glycolysis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yiming Hu, Haohao Zhang, Ningxia Xie, Dandan Liu, Yuhang Jiang, Zhi Liu, Deji Ye, Sanhong Liu, Xi Chen, Cuifeng Li, Qi Wang, Xingxu Huang, Yongzhong Liu, Yufang Shi, Xiaoren Zhang
Summary: The study demonstrates the crucial role of Bcl-3 in regulating TNF-induced hepatic cell death, with its deficiency protecting mice against hepatoxicity. Bcl-3 interacts with the deubiquitinase CYLD to facilitate the formation of death-inducing Complex II, leading to caspase cascade activation for apoptosis induction.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Nutrition & Dietetics
Yu-Chen Liu, Chun-Chao Chang, Hirofumi Matsui, Jane C. -J. Chao
Summary: This study found that C-phycocyanin (CPC) and Lycium barbarum polysaccharides (LBP) can protect against gastric damage caused by aspirin. They can reduce inflammation and decrease cell apoptosis to alleviate gastric mucosal injury. These findings suggest that CPC and LBP may be potential drugs for the treatment of gastric damage.
Article
Biotechnology & Applied Microbiology
Jiajie Feng, Jiachen Zhan, Shuangshuang Ma
Summary: In this study, the authors investigated the role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in the apoptosis and autophagy of H9c2 cells in the context of acute myocardial infarction (AMI). They found that LRG1 promotes apoptosis and autophagy under hypoxic conditions, and the effects can be reversed by downregulating LRG1 or knocking down hypoxia-inducible factor-1 alpha (HIF-1 alpha). This study provides new insights into the potential mechanisms of AMI and suggests LRG1/HIF-1 alpha pathway as a novel target for AMI treatment.
Article
Immunology
Zhenqiang Gao, Cuiting Zheng, Yaqi Xing, Xiyu Zhang, Yunfei Bai, Chen Chen, Yuanyuan Zheng, Wen Wang, Hongbing Zhang, Yan Meng
Summary: In sepsis, Plk-1 promotes the development of SIMD. Inhibition of Plk-1 improves LPS-induced myocardial injury and inflammation, and enhances the survival rate of mice. Plk-1 inhibition also impedes NF-κB signal pathway activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Juil Kim, Yuseok Moon
Summary: Kim and Moon discovered that the transcription factor PRDM1 is upregulated in colorectal cancer (CRC) cells in response to ribosomal dysfunction, leading to chemoresistance through the IGF signaling pathway. They also found that PRDM1 promotes cancer cell stemness and survival, providing insights into environmental stress-mediated signaling in CRC.
COMMUNICATIONS BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hao Yu, Zhihong Liang, Longjiao Zhu, Changhui Zhao, Xiaoyun He, Keren Chen, Wentao Xu
Summary: This review comprehensively summarizes the construction strategies and applications of nucleic acid-modified liposomes in stability enhancement, biosensing, drug delivery, and synthesis of biomimetic structures. It is concluded that nucleic acid-modified liposomes have great potential to be applied in biosensors and pharmaceuticals.
ADVANCED MATERIALS INTERFACES
(2022)
Review
Food Science & Technology
Yali Yu, Xiaoyu Lu, Tiehua Zhang, Changhui Zhao, Shiyao Guan, Yiling Pu, Feng Gao
Summary: The tiger nut is a high-quality crop with rich nutritional composition. It can be used in various food applications and has potential medical properties. However, further research and development are needed to fully explore its functional properties and processing methods for industrial production.
Review
Food Science & Technology
Changhui Zhao, Nan Chen, Tolulope Joshua Ashaolu
Summary: Studies show that whey proteins and peptides have valuable nutritional and technofunctional properties in food and drinks. They also have health-promoting characteristics and can potentially contribute to the prevention and/or adjunctive treatment of various diseases. In addition, whey proteins and peptides can protect, stabilize, and deliver functional food components.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Food Science & Technology
Yutong Zhang, Nan Chen, Naicheng Xin, Qihao Li, Tiehua Zhang, Haiqing Ye, Changhui Zhao
Summary: This study found that chlorogenic acid (CGA) can stabilize lactoferrin (LF) solution and form a relatively stable complex with LF. The complex has a synergistic anti-proliferative effect on colorectal cancer cells by arresting the cell cycle.
Review
Food Science & Technology
Nan Chen, Peng Yao, Wei Zhang, Yutong Zhang, Naicheng Xin, Hongdi Wei, Tiehua Zhang, Changhui Zhao
Summary: This review comprehensively discusses the preparation, nutritional aspect, detoxification effect, nutraceutical functions, and anti-pathogenic microorganism effects of selenium nanoparticles (SeNPs). SeNPs, compared to traditional forms of selenium, are more stable, more bioavailable, and have various positive impacts on the human body. Additionally, SeNPs have good antimicrobial effects and can be used in combination with other antimicrobial agents.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Yutong Zhang, Ye Zhang, Nan Chen, Naicheng Xin, Qihao Li, Haiqing Ye, Changhui Zhao, Tiehua Zhang
Summary: Forest frog eggs, which contain high-quality protein, can be efficiently utilized by glycating the egg protein with xylose to improve its emulsifying ability and stability. The resulting xylose glycated egg protein demonstrated excellent emulsion characteristics and could be used to encapsulate hydrophobic nutrients.
Article
Plant Sciences
Xin Shu, Rui Chen, Minglan Yang, Jia Xu, Ruxin Gao, Yanzhou Hu, Xiaoyun He, Changhui Zhao
Summary: Gynostemma pentaphyllum and Gypenoside-IV have the potential to ameliorate metabolic symptoms in high fat diet induced obese mice by modulating gut microbiota.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Food Science & Technology
Yaoyao Ji, Qiang Xie, Xiangren Meng, Wei Wang, Shengnan Li, Xinsong Lang, Changhui Zhao, Yuan Yuan, Haiqing Ye
Summary: This study demonstrates that Lactobacillus paracasei Jlus66 can effectively improve lipid metabolism disorder, mitochondrial dysfunction, insulin resistance, and inflammatory response in a mouse model of obesity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Qipeng Zhang, Wenying Chen, Boyang Zhang, Yiwen Zhang, Yuqing Xiao, Yichen An, Lingyun Han, Huiqiong Deng, Song Yao, Hongwei Wang, Xiao Li Shen
Summary: Previous studies have shown that ursolic acid (UA) can protect against ochratoxin A (OTA)-induced nephrotoxicity through Lonp1. This study investigated whether other proteins located in the mitochondria-associated endoplasmic reticulum membranes (MAMs), such as Sig-1R, also contribute to the protection of UA against OTA-induced nephrotoxicity. The results showed that OTA treatment induced apoptosis in HK-2 cells through the repression of Lonp1 and Sig-1R, and this effect was relieved by pretreatment with UA.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yan Wang, Yong Zheng, Aiyun Zhou, Jing Neng, Di Wu, Xiao Li Shen, Xiuyu Lou, Kai Yang
Summary: Pulsed light technology has been proven to effectively control fungi in postharvest fruit. This study found that pulsed light inhibited the growth of Aspergillus carbonarius in a dose-dependent manner. Pears treated with pulsed light showed reduced scab diameter and decreased levels of ergosterol and OTA.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Feng Dong, Changhui Zhao, Xiaoyun He, Yueyang Dong, Haiyan Liu, Peng Yao, Wentao Xu
Summary: This research evaluated the edible safety of Balanced Health Care Dan, a Chinese formulation-based medicinal food, using mice as experimental subjects. The results showed that the formulation did not cause any toxicological effects in mice and had the potential to be used in clinical trials.
FOOD SCIENCE & NUTRITION
(2023)
Review
Food Science & Technology
Mao-Cheng Sun, Zi-Yi Hu, Dian-Dian Li, Yu-Xin Chen, Jing-Hui Xi, Chang-Hui Zhao
Summary: The reuterin system produced by Limosilactobacillus reuteri is a complex multi-component antimicrobial system with potential applications in the food and medical industries. It possesses various activities such as regulation of intestinal flora, anti-infection, anti-inflammatory, and anti-cancer effects. Although the antimicrobial mechanism and toxicity of the reuterin system are still unclear, this updated review provides valuable information on its biosynthesis, composition, production, mechanisms, stability, toxicity, and potential applications. Challenges and opportunities for using the reuterin system as a food preservative or health-promoting agent are also discussed.
Article
Food Science & Technology
Huiqiong Deng, Wenying Chen, Boyang Zhang, Yiwen Zhang, Lingyun Han, Qipeng Zhang, Song Yao, Hongwei Wang, Xiao Li Shen
Summary: This study reveals that the nephrotoxic effect of ochratoxin A (OTA) on human proximal tubule epithelial (HK-2) cells is mediated by the activation of endoplasmic reticulum stress (ERS) and excessive ER-phagy, leading to apoptosis. The vicious cycle between excessive ER-phagy and ERS contributes to the promotion of apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Yutong Zhang, Naicheng Xin, Tolulope Joshua Ashaolu, Nan Chen, Yanli Wang, Tiehua Zhang, Changhui Zhao
Summary: In this study, chlorogenic acid (CGA) was used to interact with lactoferrin (LF) to form nanoscale complex. The structure and function of LF complexed with CGA at different ratios were analyzed. The interaction between LF and CGA changed LF's characteristic UV and fluorescent spectra, and the fluorescence quenching mechanism was static quenching. The LF-CGA complex showed decreased hydrophobicity and increased solubility, and its foaming ability and antioxidant activity in vitro were enhanced.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Yuting Guan, Chanyuan Xie, Rui Zhang, Ziyang Zhang, Zhenyang Tian, Jianing Feng, Xiaoyong Shen, Haiqin Li, Shimin Chang, Changhui Zhao, Ran Chai
Summary: Black rice was fermented using Neurospora crassa to extract dietary fiber (DF), which was then characterized and evaluated for its cholesterol-lowering effect in mice. The findings showed that fermentation increased soluble DF content and enhanced DF's adsorption capacity for various substances. The fermented DF also had a different structure compared to unfermented DF. Additionally, feeding mice with DF from fermented black rice led to weight loss, reduced total cholesterol levels, and improved lipid profile.
