Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
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Title
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
Authors
Keywords
Antibodies, HIV, Insertion mutation, Deletion mutation, Crystal structure, Microbial mutation, Antigens, Sequence databases
Journal
PLoS Pathogens
Volume 12, Issue 8, Pages e1005815
Publisher
Public Library of Science (PLoS)
Online
2016-08-26
DOI
10.1371/journal.ppat.1005815
References
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Note: Only part of the references are listed.- HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
- (2016) J. G. Jardine et al. SCIENCE
- Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
- (2016) Andrew T. McGuire et al. Nature Communications
- Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice
- (2015) Pia Dosenovic et al. CELL
- Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
- (2015) Tongqing Zhou et al. CELL
- Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection
- (2015) Xueling Wu et al. CELL
- Databases of Conformations and NMR Structures of Glycan Determinants
- (2015) Anita Sarkar et al. GLYCOBIOLOGY
- HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies
- (2015) Rebecca M. Lynch et al. JOURNAL OF VIROLOGY
- High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
- (2015) Ryan L Kelly et al. mAbs
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
- (2015) J. G. Jardine et al. SCIENCE
- HIV-1 neutralizing antibodies induced by native-like envelope trimers
- (2015) R. W. Sanders et al. SCIENCE
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site
- (2015) Ema T. Crooks et al. PLoS Pathogens
- Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
- (2014) Feng Gao et al. CELL
- Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies
- (2014) Thomas B. Kepler et al. Cell Host & Microbe
- Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
- (2014) Emilia Falkowska et al. IMMUNITY
- Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
- (2014) Masashi Shingai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline
- (2014) I. S. Georgiev et al. JOURNAL OF IMMUNOLOGY
- Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
- (2014) R. S. Rudicell et al. JOURNAL OF VIROLOGY
- Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
- (2014) Jinghe Huang et al. NATURE
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
- (2014) Brandon J DeKosky et al. NATURE MEDICINE
- Identification and characterization of the constituent human serum antibodies elicited by vaccination
- (2014) Jason J. Lavinder et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
- (2014) Devin Sok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies
- (2014) A. T. McGuire et al. SCIENCE
- Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
- (2014) J. B. Munro et al. SCIENCE
- Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
- (2014) A. Pegu et al. Science Translational Medicine
- Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
- (2014) D. Sok et al. Science Translational Medicine
- Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization
- (2014) Arthur S. Kim et al. PLoS Pathogens
- Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity
- (2014) Erin M. Scherer et al. PLoS Pathogens
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
- (2013) Florian Klein et al. CELL
- Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
- (2013) Tongqing Zhou et al. IMMUNITY
- Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2
- (2013) Hua-Xin Liao et al. IMMUNITY
- HIV-1 neutralizing antibodies: understanding nature's pathways
- (2013) John R. Mascola et al. IMMUNOLOGICAL REVIEWS
- Immunogenicity of 2 Doses of HPV Vaccine in Younger Adolescents vs 3 Doses in Young Women
- (2013) Simon R. M. Dobson et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
- (2013) Andrew T. McGuire et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
- (2013) Ron Diskin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool
- (2013) Y. Xu et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
- (2013) J. Jardine et al. SCIENCE
- PANDAseq: paired-end assembler for illumina sequences
- (2012) Andre P Masella et al. BMC BIOINFORMATICS
- Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers
- (2012) Rafael S. Depetris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family
- (2012) M. Bonsignori et al. JOURNAL OF VIROLOGY
- HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes
- (2012) N. A. Doria-Rose et al. JOURNAL OF VIROLOGY
- Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
- (2012) Jinghe Huang et al. NATURE
- B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
- (2012) Barton F Haynes et al. NATURE BIOTECHNOLOGY
- Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape
- (2012) Penny L Moore et al. NATURE MEDICINE
- Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes
- (2012) Bryan S. Briney et al. PLoS One
- Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
- (2012) B. Moldt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
- (2012) Anthony P. West et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
- (2011) Jens Wrammert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors
- (2011) M. Bonsignori et al. JOURNAL OF VIROLOGY
- The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
- (2011) E. S. Gray et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
- (2011) X. Wu et al. SCIENCE
- Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
- (2011) R. Diskin et al. SCIENCE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1
- (2011) Iliyana Mikell et al. PLoS Pathogens
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
- (2010) R. Pejchal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
- (2010) K. J. Doores et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
- (2010) X. Wu et al. SCIENCE
- Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen
- (2009) Kenneth Smith et al. Nature Protocols
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Challenges for structure-based HIV vaccine design
- (2009) William R Schief et al. Current Opinion in HIV and AIDS
- IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
- (2008) X. Brochet et al. NUCLEIC ACIDS RESEARCH
- IMGT(R), the international ImMunoGeneTics information system(R)
- (2008) M.-P. Lefranc et al. NUCLEIC ACIDS RESEARCH
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