Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

HIV-1 neutralizing antibodies: understanding nature's pathways

(2013) John R. Mascola et al.   IMMUNOLOGICAL REVIEWS

The HIV-1 gp120 Major Variable Regions Modulate Cold Inactivation

(2013) H. Medjahed et al.   JOURNAL OF VIROLOGY

Inhibition of the HIV-1 Spike by Single-PG9/16-Antibody Binding Suggests a Coordinated-Activation Model for Its Three Protomeric Units

(2013) R. Loving et al.   JOURNAL OF VIROLOGY

Antibody-Dependent, Fc RI-Mediated Neutralization of HIV-1 in TZM-bl Cells Occurs Independently of Phagocytosis

(2013) L. G. Perez et al.   JOURNAL OF VIROLOGY

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

(2013) Leopold Kong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

(2013) Kristin M. Narayan et al.   PLoS One

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

(2013) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

(2013) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41

(2013) Ashraf I Khasawneh et al.   Retrovirology

Antibodies in HIV-1 Vaccine Development and Therapy

(2013) F. Klein et al.   SCIENCE

Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution

(2013) Daniel P. Leaman et al.   PLoS Pathogens

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

(2013) Jean-Philippe Julien et al.   PLoS Pathogens

A Blueprint for HIV Vaccine Discovery

(2012) Dennis R. Burton et al.   Cell Host & Microbe

Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane

(2012) M. Montero et al.   JOURNAL OF VIROLOGY

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

(2012) Jinghe Huang et al.   NATURE

Recognition of Membrane-Bound Fusion-Peptide/MPER Complexes by the HIV-1 Neutralizing 2F5 Antibody: Implications for Anti-2F5 Immunogenicity

(2012) Nerea Huarte et al.   PLoS One

Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function

(2012) Javier Guenaga et al.   PLoS Pathogens

Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

(2012) Erin E. H. Tran et al.   PLoS Pathogens

Targeting HIV-1 gp41 in Close Proximity to the Membrane Using Antibody and Other Molecules

(2011) Johannes S. Gach et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1

(2011) Claudia R. Ruprecht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct Antibody Access to the HIV-1 Membrane-Proximal External Region Positively Correlates with Neutralization Sensitivity

(2011) B. K. Chakrabarti et al.   JOURNAL OF VIROLOGY

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

(2011) Mikyung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Stability of Unliganded Envelope Glycoprotein Spikes among Isolates of Human Immunodeficiency Virus Type 1 (HIV-1)

(2011) Nitish Agrawal et al.   PLoS One

The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade

(2011) Camille Bonomelli et al.   PLoS One

Synthesis and analysis of the membrane proximal external region epitopes of HIV-1

(2010) Sampat Ingale et al.   JOURNAL OF PEPTIDE SCIENCE

In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1

(2010) D. P. Leaman et al.   JOURNAL OF VIROLOGY

Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

(2010) J. M. Binley et al.   JOURNAL OF VIROLOGY

Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies

(2010) Gary Frey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

4E10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms

(2010) Kyle J. Nakamura et al.   PLoS One

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions

(2010) Victor Buzon et al.   PLoS Pathogens

Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation†,‡

(2009) Jie Liu et al.   BIOCHEMISTRY

Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

(2009) H. Xu et al.   JOURNAL OF VIROLOGY

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

(2009) R. Pejchal et al.   JOURNAL OF VIROLOGY

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10

(2009) J. S. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of HIV membrane in neutralization by two broadly neutralizing antibodies

(2009) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer

(2009) Karl Salzwedel et al.   Retrovirology

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

(2008) Zhen-Yu J. Sun et al.   IMMUNITY

The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design

(2008) M. Montero et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

(2008) G. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the steric defense of the HIV-1 gp41 N-trimer region

(2008) Debra M. Eckert et al.   PROTEIN SCIENCE

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

(2008) Josh D. Nelson et al.   VIROLOGY

Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization

(2008) Emma T. Crooks et al.   VIROLOGY

Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41

(2007) Catherine A Blish et al.   PLOS MEDICINE