Resveratrol Reverses Functional Chagas Heart Disease in Mice

Resveratrol inhibits Trypanosoma cruzi arginine kinase and exerts a trypanocidal activity

(2016) Edward A. Valera Vera et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms

(2015) Robert G. Britton et al.   Annals of the New York Academy of Sciences

The pharmacology of resveratrol in animals and humans

(2015) Eun-Jung Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetic Cardiovascular Disease Induced by Oxidative Stress

(2015) Yosuke Kayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis

(2015) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Is AMPK the savior of the failing heart?

(2015) Ty T. Kim et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8+ T-Cell Response

(2015) Isabela Resende Pereira et al.   PLoS Neglected Tropical Diseases

Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity

(2015) Debora B. Mello et al.   PLoS Neglected Tropical Diseases

Chagas Disease Cardiomyopathy: Immunopathology and Genetics

(2014) Edecio Cunha-Neto et al.   MEDIATORS OF INFLAMMATION

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria

(2014) Ivo M. B. Francischetti et al.   PLoS One

Resveratrol protects rabbit ventricular myocytes against oxidative stress-induced arrhythmogenic activity and Ca2+ overload

(2013) Wei Li et al.   ACTA PHARMACOLOGICA SINICA

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation

(2013) Istvan Baczko et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potential of resveratrol in the treatment of heart failure

(2013) Pema Raj et al.   LIFE SCIENCES

Resveratrol Alleviates Endotoxin-Induced Myocardial Toxicity via the Nrf2 Transcription Factor

(2013) Enkui Hao et al.   PLoS One

Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection

(2013) A. M. Jamieson et al.   SCIENCE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Oxidative stress fuels Trypanosoma cruzi infection in mice

(2012) Claudia N. Paiva et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnosis and management of Chagas disease and cardiomyopathy

(2012) Antonio L. Ribeiro et al.   Nature Reviews Cardiology

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Administration of resveratrol: What formulation solutions to bioavailability limitations?

(2011) A. Amri et al.   JOURNAL OF CONTROLLED RELEASE

NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease

(2011) Monisha Dhiman et al.   JOURNAL OF PATHOLOGY

Enhancing the bioavailability of resveratrol by combining it with piperine

(2011) Jeremy J. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aspirin Treatment of Mice Infected with Trypanosoma cruzi and Implications for the Pathogenesis of Chagas Disease

(2011) Shankar Mukherjee et al.   PLoS One

Mitochondrial involvement in chronic chagasic cardiomyopathy

(2011) Alejandra Báez et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart

(2010) Heng Ma et al.   CIRCULATION

Favorable effects of resveratrol on sympathetic neural remodeling in rats following myocardial infarction

(2010) Ping Xin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ECG Detection of Murine Chagasic Cardiomyopathy

(2010) Christopher S. Eickhoff et al.   JOURNAL OF PARASITOLOGY

Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic Rats

(2010) Jian-Jun Wen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chagas disease

(2010) Anis Rassi et al.   LANCET

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Mitochondrial generation of reactive oxygen species is enhanced at the Qo site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant

(2008) Jian-Jun Wen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY