Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms

Peroxisome Proliferator-Activated Receptor γ and Lung Cancer Biology

(2016) Jesse Roman   JOURNAL OF INVESTIGATIVE MEDICINE

Resveratrol and Its Metabolites Bind to PPARs

(2014) Enrica Calleri et al.   CHEMBIOCHEM

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview

(2014) P.R.A. Heckman et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol: Anti-Obesity Mechanisms of Action

(2014) Leixuri Aguirre et al.   MOLECULES

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol

(2014) Mathew Sajish et al.   NATURE

COX-2 as a target for cancer chemotherapy

(2014) Nilanjan Ghosh et al.   Pharmacological Reports

Biochemical and Cellular Evidence Demonstrating AKT-1 as a Binding Partner for Resveratrol Targeting Protein NQO2

(2014) Tze-chen Hsieh et al.   PLoS One

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

(2014) Neoh Hun Phuah et al.   Biomed Research International

Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase

(2013) Yan Liang et al.   BMC Complementary and Alternative Medicine

Roflumilast: the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD

(2013) Donald P Tashkin   EXPERT OPINION ON PHARMACOTHERAPY

mTOR: more targets of resveratrol?

(2013) Anne L. Widlund et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Identification of Carbonyl Reductase 1 as a Resveratrol-Binding Protein by Affinity Chromatography Using 4'-Amino-3,5-dihydroxy-trans-stilbene

(2013) Yuta ITO et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells

(2013) Sascha Venturelli et al.   PLoS One

Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence

(2013) K. R. Patel et al.   Science Translational Medicine

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement

(2013) Stuart Richer et al.   Nutrients

Finding a Target for Resveratrol

(2012) Ruth I. Tennen et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Control of MicroRNA Expression as a New Way for Resveratrol To Deliver Its Beneficial Effects

(2012) Allan Lançon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiovascular effects and molecular targets of resveratrol

(2012) Huige Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Fruits and dietary phytochemicals in bone protection

(2012) Chwan-Li Shen et al.   NUTRITION RESEARCH

Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action

(2012) Qiang Xu et al.   NUTRITION RESEARCH

Aspirin in the Chemoprevention of Colorectal Neoplasia: An Overview

(2011) A. T. Chan et al.   Cancer Prevention Research

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease

(2011) W. Wang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Emerging Roles of Protein Kinase D1 in Cancer

(2011) V. Sundram et al.   MOLECULAR CANCER RESEARCH

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

(2010) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

(2010) Puspa R. Pandey et al.   BREAST CANCER RESEARCH AND TREATMENT

Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase

(2010) N. Oi et al.   CANCER RESEARCH

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

(2010) Albert Y. Sun et al.   MOLECULAR NEUROBIOLOGY

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

(2009) Mohammad Athar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

(2009) Jin-Taek Hwang et al.   New Biotechnology

Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives

(2008) Joydeb Kumar Kundu et al.   CANCER LETTERS

Phosphodiesterase inhibition in heart failure

(2008) Matthew Movsesian et al.   HEART FAILURE REVIEWS

Resveratrol directly targets COX-2 to inhibit carcinogenesis

(2008) Tatyana A. Zykova et al.   MOLECULAR CARCINOGENESIS