Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
出版年份 2016 全文链接
标题
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
作者
关键词
Type 2 diabetes, Genetic loci, Isoleucine, Amino acid analysis, Meta-analysis, Leucine, Metabolic pathways, Valine
出版物
PLOS MEDICINE
Volume 13, Issue 11, Pages e1002179
出版商
Public Library of Science (PLoS)
发表日期
2016-11-30
DOI
10.1371/journal.pmed.1002179
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes
- (2016) Luca A. Lotta et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Human gut microbes impact host serum metabolome and insulin sensitivity
- (2016) Helle Krogh Pedersen et al. NATURE
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
- (2016) Robert A. Scott et al. Science Translational Medicine
- Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
- (2015) Pasi Soininen et al. Circulation-Cardiovascular Genetics
- Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
- (2015) Erin L. Glynn et al. DIABETOLOGIA
- Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
- (2015) Therese Tillin et al. DIABETOLOGIA
- Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study
- (2015) Nicholette D. Palmer et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
- (2015) Brian A. Ference et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- New genetic loci link adipose and insulin biology to body fat distribution
- (2015) Dmitry Shungin et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
- (2015) Po-Ru Loh et al. NATURE GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
- (2015) Stephen Burgess et al. STATISTICS IN MEDICINE
- Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
- (2015) Søren D. Østergaard et al. PLOS MEDICINE
- Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics
- (2015) Pasi Soininen et al. Circulation-Cardiovascular Genetics
- Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism
- (2014) Andrew C. Shin et al. Cell Metabolism
- Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
- (2014) Kun Lian et al. DIABETES
- Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
- (2014) R. A. Scott et al. DIABETES
- Roux-en-Y Gastric Bypass Surgery, but Not Calorie Restriction, Reduces Plasma Branched-Chain Amino Acids in Obese Women Independent of Weight Loss or the Presence of Type 2 Diabetes
- (2014) Mirjam A. Lips et al. DIABETES CARE
- Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
- (2014) Shih-Chia Tso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders
- (2014) Lindsay C. Burrage et al. MOLECULAR GENETICS AND METABOLISM
- An atlas of genetic influences on human blood metabolites
- (2014) So-Youn Shin et al. NATURE GENETICS
- Branched-chain amino acids in metabolic signalling and insulin resistance
- (2014) Christopher J. Lynch et al. Nature Reviews Endocrinology
- Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change
- (2014) Peter Würtz et al. PLOS MEDICINE
- A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort
- (2013) Eugene P. Rhee et al. Cell Metabolism
- Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss Diets
- (2013) Min Xu et al. CIRCULATION
- Metabolite Profiles During Oral Glucose Challenge
- (2013) Jennifer E. Ho et al. DIABETES
- Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
- (2013) C. Menni et al. DIABETES
- Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
- (2013) Stephen Burgess et al. GENETIC EPIDEMIOLOGY
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain -ketoacid dehydrogenase kinase
- (2013) S.-C. Tso et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
- (2013) V. K. Ridaura et al. SCIENCE
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance
- (2012) Christopher B. Newgard Cell Metabolism
- Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
- (2012) A. Floegel et al. DIABETES
- The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
- (2012) Eiji Kakazu et al. Hepatology International
- A Novel Regulatory Defect in the Branched-Chain α-Keto Acid Dehydrogenase Complex Due to a Mutation in thePPM1KGene Causes a Mild Variant Phenotype of Maple Syrup Urine Disease
- (2012) Alfonso Oyarzabal et al. HUMAN MUTATION
- What makes UK Biobank special?
- (2012) Rory Collins LANCET
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Novel biomarkers for pre-diabetes identified by metabolomics
- (2012) Rui Wang-Sattler et al. Molecular Systems Biology
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Genome-wide association study identifies multiple loci influencing human serum metabolite levels
- (2012) Johannes Kettunen et al. NATURE GENETICS
- Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
- (2011) Changting Xiao et al. DIABETES
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- (2011) DIABETOLOGIA
- Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
- (2011) Eugene P. Rhee et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolite profiles and the risk of developing diabetes
- (2011) Thomas J Wang et al. NATURE MEDICINE
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Phenylbutyrate therapy for maple syrup urine disease
- (2010) Nicola Brunetti-Pierri et al. HUMAN MOLECULAR GENETICS
- Genotype imputation for genome-wide association studies
- (2010) Jonathan Marchini et al. NATURE REVIEWS GENETICS
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
- (2009) Christopher B. Newgard et al. Cell Metabolism
- Molecular and Metabolic Evidence for Mitochondrial Defects Associated With -Cell Dysfunction in a Mouse Model of Type 2 Diabetes
- (2009) H. Lu et al. DIABETES
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells
- (2009) Gang Lu et al. JOURNAL OF CLINICAL INVESTIGATION
- SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
- (2008) A. D. Johnson et al. BIOINFORMATICS
- Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
- (2008) Oded Shaham et al. Molecular Systems Biology
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