NMR Methods to Study Dynamic Allostery

Kinetic Cooperativity in Human Pancreatic Glucokinase Originates from Millisecond Dynamics of the Small Domain

(2015) Mioara Larion et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allostery without a conformational change? Revisiting the paradigm

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway

(2015) David Oyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I

(2015) Vincenzo Venditti et al.   Nature Communications

Dynamic Allostery of the Catabolite Activator Protein Revealed by Interatomic Forces

(2015) Maxime Louet et al.   PLoS Computational Biology

The Expanding View of RNA and DNA Function

(2014) Ronald R. Breaker et al.   CHEMISTRY & BIOLOGY

E pluribus unum, no more: from one crystal, many conformations

(2014) Rahel A Woldeyes et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Chemical exchange in biomacromolecules: Past, present, and future

(2014) Arthur G. Palmer   JOURNAL OF MAGNETIC RESONANCE

An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange

(2014) Andrew J. Baldwin   JOURNAL OF MAGNETIC RESONANCE

Evidence Against the “Y–T Coupling” Mechanism of Activation in the Response Regulator NtrC

(2014) Janice Villali et al.   JOURNAL OF MOLECULAR BIOLOGY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Tracing an allosteric pathway regulating the activity of the HslV protease

(2014) Lichi Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prepaying the entropic cost for allosteric regulation in KIX

(2014) S. M. Law et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

(2014) Hoi Tik Alvin Leung et al.   PROTEIN SCIENCE

Conformational Dynamics of a Regulator of G-Protein Signaling Protein Reveals a Mechanism of Allosteric Inhibition by a Small Molecule

(2013) Harish Vashisth et al.   ACS Chemical Biology

Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core

(2013) Sven Brüschweiler et al.   ACS Chemical Biology

The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding

(2013) Maxime J. C. Audin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solution NMR and Computational Methods for Understanding Protein Allostery

(2013) Gregory Manley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Simple Method to Measure Protein Side-Chain Mobility Using NMR Chemical Shifts

(2013) Mark V. Berjanskii et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric inhibition through suppression of transient conformational states

(2013) Shiou-Ru Tzeng et al.   Nature Chemical Biology

From Metadynamics to Dynamics

(2013) Pratyush Tiwary et al.   PHYSICAL REVIEW LETTERS

Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution

(2013) Andrea Haller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The allosteric communication pathways in KIX domain of CBP

(2013) F. Palazzesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

(2012) Levi C.T. Pierce et al.   Journal of Chemical Theory and Computation

Local Folding and Misfolding in the PBX Homeodomain from a Three-State Analysis of CPMG Relaxation Dispersion NMR Data

(2012) Patrick J. Farber et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Allosteric pathways in imidazole glycerol phosphate synthase

(2012) I. Rivalta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome allostery as a population shift between interchanging conformers

(2012) A. M. Ruschak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Control of the Binding of the Transactivation Domain of the MLL Protein and c-Myb to the KIX Domain of CREB

(2012) Elif Nihal Korkmaz et al.   PLoS Computational Biology

An Optimized Relaxation-Based Coherence Transfer NMR Experiment for the Measurement of Side-Chain Order in Methyl-Protonated, Highly Deuterated Proteins

(2011) Hechao Sun et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Determining Valine Side-Chain Rotamer Conformations in Proteins from Methyl13C Chemical Shifts: Application to the 360 kDa Half-Proteasome

(2011) D. Flemming Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

(2011) A. Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR reveals novel mechanisms of protein activity regulation

(2011) Charalampos G. Kalodimos   PROTEIN SCIENCE

Concerted Dynamics Link Allosteric Sites in the PBX Homeodomain

(2010) Patrick J. Farber et al.   JOURNAL OF MOLECULAR BIOLOGY

Determination of Isoleucine Side-Chain Conformations in Ground and Excited States of Proteins from Chemical Shifts

(2010) D. Flemming Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis underlying the dual gate properties of KcsA

(2010) S. Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR

(2010) T. L. Religa et al.   SCIENCE

Nanometer Propagation of Millisecond Motions in V-Type Allostery

(2010) James M. Lipchock et al.   STRUCTURE

Leucine Side-Chain Conformation and Dynamics in Proteins from13C NMR Chemical Shifts

(2009) Frans A. A. Mulder   CHEMBIOCHEM

Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins

(2009) Ivet Bahar et al.   CHEMICAL REVIEWS

Fast Two-Dimensional NMR Spectroscopy of High Molecular Weight Protein Assemblies

(2009) Carlos Amero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of the Dynamic Process Underlying Allosteric Signal Transmission

(2009) Sven Brüschweiler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Dependence of Amino Acid Side Chain13C Shifts on Dihedral Angle: Application to Conformational Analysis

(2008) Robert E. London et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

(2008) Julius Rabl et al.   MOLECULAR CELL

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

(2008) Pilong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE