NMR reveals novel mechanisms of protein activity regulation

Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression

(2010) Zhanxin Wang et al.   CELL

Using NMR to study fast dynamics in proteins: methods and applications

(2010) Paul J Sapienza et al.   CURRENT OPINION IN PHARMACOLOGY

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for regulation of the Crk signaling protein by a proline switch

(2010) Paramita Sarkar et al.   Nature Chemical Biology

Dynamics connect substrate recognition to catalysis in protein kinase A

(2010) Larry R Masterson et al.   Nature Chemical Biology

The role of conformational entropy in molecular recognition by calmodulin

(2010) Michael S Marlow et al.   Nature Chemical Biology

The twist in Crk signaling revealed

(2010) Linda K Nicholson et al.   Nature Chemical Biology

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

(2010) Jodi Gureasko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR

(2010) T. L. Religa et al.   SCIENCE

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution

(2010) Dmitry M. Korzhnev et al.   SCIENCE

Nanometer Propagation of Millisecond Motions in V-Type Allostery

(2010) James M. Lipchock et al.   STRUCTURE

Structural overview on the allosteric activation of cyclic AMP receptor protein

(2009) Hyung-Sik Won et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

(2009) Raymond B Birge et al.   Cell Communication and Signaling

A Conformational Switch in the Scaffolding Protein NHERF1 Controls Autoinhibition and Complex Formation

(2009) Shibani Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains

(2009) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline Isomerization Preorganizes the Itk SH2 Domain for Binding to the Itk SH3 Domain

(2009) Andrew Severin et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Observation of the Dynamic Process Underlying Allosteric Signal Transmission

(2009) Sven Brüschweiler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

(2009) Diego Alvarado et al.   NATURE

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

NMR spectroscopy brings invisible protein states into focus

(2009) Andrew J Baldwin et al.   Nature Chemical Biology

Regulating transcription regulators via allostery and flexibility: Fig. 1.

(2009) Dorothy Beckett   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for cAMP-mediated allosteric control of the catabolite activator protein

(2009) N. Popovych et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State

(2009) Randall V. Mauldin et al.   STRUCTURE

Observing biological dynamics at atomic resolution using NMR

(2009) Anthony K. Mittermaier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory and Long-Range Changes in Picosecond–Nanosecond Main-Chain Dynamics upon Complex Formation: 15N Relaxation Analysis of the Free and Bound States of the Ubiquitin-like Domain of Human Plexin-B1 and the Small GTPase Rac1

(2008) S. Bouguet-Bonnet et al.   JOURNAL OF MOLECULAR BIOLOGY

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Estimation of the available free energy in a LOV2-Jα photoswitch

(2008) Xiaolan Yao et al.   Nature Chemical Biology

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

A regulatable switch mediates self-association in an immunoglobulin fold

(2008) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

(2008) Pilong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE

A Functional Proline Switch in Cytochrome P450cam

(2008) Bo OuYang et al.   STRUCTURE

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES