The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics

The role of USP1 autocleavage in DNA interstrand crosslink repair

(2016) Mira Kim et al.   FEBS LETTERS

Cutaneous cylindroma: it's all about MYB

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

(2016) Syed Arif Abdul Rehman et al.   MOLECULAR CELL

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

(2016) Byung-Hoon Lee et al.   NATURE

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

(2016) Danny D. Sahtoe et al.   Nature Communications

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets

(2016) Adan Pinto-Fernandez et al.   Frontiers in Genetics

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase

(2015) Y. Zhao et al.   EMBO JOURNAL

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

(2015) Salima Daou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Plasticity Allows UCH37 to Be Primed by RPN13 or Locked Down by INO80G

(2015) Xiang Chen et al.   MOLECULAR CELL

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

Loss of BAP1 function leads to EZH2-dependent transformation

(2015) Lindsay M LaFave et al.   NATURE MEDICINE

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome

(2015) Charlene Bashore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection

(2015) Hailong Liu et al.   Cell Reports

The Deubiquitinating Enzyme USP24 Is a Regulator of the UV Damage Response

(2015) Ling Zhang et al.   Cell Reports

The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

(2015) Cláudia P. Grou et al.   Scientific Reports

The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

(2014) Helen Walden et al.   Annual Review of Biophysics

USP7 controls Chk1 protein stability by direct deubiquitination

(2014) Ignacio Alonso-de Vega et al.   CELL CYCLE

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

(2014) B Wang et al.   CELL DEATH AND DIFFERENTIATION

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

(2014) Wen Yue et al.   CELL RESEARCH

Ubpy controls the stability of the ESCRT-0 subunit Hrs in development

(2014) J. Zhang et al.   DEVELOPMENT

Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

(2014) Jinshan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP28 Is Recruited to Sites of DNA Damage by the Tandem BRCT Domains of 53BP1 but Plays a Minor Role in Double-Strand Break Metabolism

(2014) P. A. Knobel et al.   MOLECULAR AND CELLULAR BIOLOGY

Autoregulation of the 26S proteasome by in situ ubiquitination

(2014) Andrew D. Jacobson et al.   MOLECULAR BIOLOGY OF THE CELL

Fine-Tuning of DNA Damage-Dependent Ubiquitination by OTUB2 Supports the DNA Repair Pathway Choice

(2014) Kiyoko Kato et al.   MOLECULAR CELL

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX

(2014) M. Rocío Delgado-Díaz et al.   Molecular Oncology

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

(2014) Jian Yuan et al.   NUCLEIC ACIDS RESEARCH

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability

(2014) J Qian et al.   ONCOGENE

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination

(2014) Y Martín et al.   ONCOGENE

USP8 Controls the Trafficking and Sorting of Lysosomal Enzymes

(2014) Ewan MacDonald et al.   TRAFFIC

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

Mechanism of Recruitment and Activation of the Endosome-Associated Deubiquitinase AMSH

(2013) Christopher W. Davies et al.   BIOCHEMISTRY

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

(2013) Nidhi Sharma et al.   CELL CYCLE

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover

(2013) M Bohgaki et al.   CELL DEATH AND DIFFERENTIATION

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

(2013) Alo Ray et al.   DNA REPAIR

Ubiquitin-specific Protease 7 Is a Regulator of Ubiquitin-conjugating Enzyme UbE2E1

(2013) Feroz Sarkari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analog AC17 Causes NF- B Inhibition and p53 Reactivation in Human Lung Cancer Cells

(2013) B. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

(2013) Jing Huang et al.   MOLECULAR CELL

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

(2013) Andreas Kakarougkas et al.   NUCLEIC ACIDS RESEARCH

OTUD5 Regulates p53 Stability by Deubiquitinating p53

(2013) Judong Luo et al.   PLoS One

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

(2012) S. B. Chernikova et al.   CANCER RESEARCH

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

(2012) Olga A. Issaenko et al.   CELL CYCLE

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

(2012) Marco Gatti et al.   CELL CYCLE

Profiling Ubiquitin Linkage Specificities of Deubiquitinating Enzymes with Branched Ubiquitin Isopeptide Probes

(2012) Alexander Iphöfer et al.   CHEMBIOCHEM

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

(2012) Céline Reverdy et al.   CHEMISTRY & BIOLOGY

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

(2012) Yang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYLD Inhibits Melanoma Growth and Progression through Suppression of the JNK/AP-1 and β1-Integrin Signaling Pathways

(2012) Hengning Ke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Targeting Deubiquitinases Enabled by Chemical Synthesis of Proteins

(2012) Shimrit Ohayon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase   Recruitment to DNA Damage Sites

(2012) C. B. Whitehurst et al.   JOURNAL OF VIROLOGY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The mechanism of OTUB1-mediated inhibition of ubiquitination

(2012) Reuven Wiener et al.   NATURE

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

(2012) Joseph Weinstock et al.   ACS Medicinal Chemistry Letters

Eukaryotic endonuclease VIII-Like proteins: New components of the base excision DNA repair system

(2011) I. R. Grin et al.   BIOCHEMISTRY-MOSCOW

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

(2011) Sajjad Hussain et al.   CELL CYCLE

Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork

(2011) Stephanie Brown et al.   CELL CYCLE

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Selective and Cell-Active Inhibitors of the USP1/ UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells

(2011) Junjun Chen et al.   CHEMISTRY & BIOLOGY

Cellular strategies for making monoubiquitin signals

(2011) Harish N. Ramanathan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

(2011) Andreas K Hock et al.   EMBO JOURNAL

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

(2011) Juhong Liu et al.   EMBO JOURNAL

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

(2011) Mariola J. Edelmann et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

(2011) Jean-Hugues Guervilly et al.   HUMAN MOLECULAR GENETICS

Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme

(2011) Thomas M. Durcan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β

(2011) Jason L. Parsons et al.   MOLECULAR CELL

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

(2011) Neesar Ahmed et al.   NATURE IMMUNOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Atlas of Altered Expression of Deubiquitinating Enzymes in Human Cancer

(2011) Chiara Luise et al.   PLoS One

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

Characterization of Selective Ubiquitin and Ubiquitin-Like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format

(2010) Xufan Tian et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Regulation of the Polycomb protein RING1B ubiquitination by USP7

(2010) Prim de Bie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Unlocking the Mdm2-p53 loop: Ubiquitin is the key

(2010) Hilary V. Clegg et al.   CELL CYCLE

A screen for deubiquitinating enzymes involved in the G2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability

(2010) Bernadette Aressy et al.   CELL CYCLE

The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma

(2010) L. Li et al.   CLINICAL CANCER RESEARCH

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

(2010) Tracey A. Dobbs et al.   DNA REPAIR

Cell Death and Survival Signaling in Oncogenesis

(2010) S. Fulda   KLINISCHE PADIATRIE

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

(2010) Yaron Pereg et al.   NATURE CELL BIOLOGY

Ubiquitin chain cleavage: CYLD at work

(2010) Ramin Massoumi   TRENDS IN BIOCHEMICAL SCIENCES

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation

(2010) Julien Moretti et al.   PLOS BIOLOGY

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2

(2009) Burcu Hasdemir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

(2009) Helene Faustrup et al.   JOURNAL OF CELL BIOLOGY

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

(2009) F. Colland et al.   MOLECULAR CANCER THERAPEUTICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)

(2008) Marcin Drag et al.   BIOCHEMICAL JOURNAL

Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

(2008) Maria Fousteri et al.   CELL RESEARCH

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Inhibition of p97-dependent Protein Degradation by Eeyarestatin I

(2008) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53

(2008) Saurabh Dayal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-Remodeling Complex

(2008) Tingting Yao et al.   MOLECULAR CELL

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE